A5047594507- Innovative Microfluidic and Catalytic Techniques Innovation
- Neurotransmitter Receptor Influence on Behavior
- Space exploration and regulation
- Military and Defense Studies
- Terrorism, Counterterrorism, and Political Violence
- Enzyme Catalysis and Immobilization
- Intermetallics and Advanced Alloy Properties
- Olfactory and Sensory Function Studies
- Nicotinic Acetylcholine Receptors Study
- Advanced Cellulose Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Lignin and Wood Chemistry
- High-Temperature Coating Behaviors
- Space Science and Extraterrestrial Life
- Process Optimization and Integration
- Chemistry and Chemical Engineering
- Metallurgical Processes and Thermodynamics
- Military, Security, and Education Studies
- Politics and Conflicts in Afghanistan, Pakistan, and Middle East
- Canadian Identity and History
- Protein purification and stability
- International Law and Aviation
- Neuroscience and Neuropharmacology Research
- International Science and Diplomacy
- Military History and Strategy
Brigham Young University
2023-2024
Iowa State University
2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
2020-2023
Centerforce
2010-2014
West Virginia University
2005
Iboga alkaloids, also known as coronaridine congeners, have shown promise in the treatment of alcohol and opioid use disorders. The objective this study was to evaluate effects catharanthine 18-methoxycoronaridine (18-MC) on dopamine (DA) transmission cholinergic interneurons mesolimbic DA system, nicotine-induced locomotor activity, nicotine-taking behavior. Utilizing ex vivo fast-scan cyclic voltammetry (FSCV) nucleus accumbens core male mice, we found that or 18-MC differentially...
Peripheral mechanoreceptor-based treatments such as acupuncture and chiropractic manipulation have shown success in modulating the mesolimbic dopamine (DA) system originating ventral tegmental area (VTA) of midbrain projecting to nucleus accumbens (NAc) striatum. We previously that mechanoreceptor activation via whole-body vibration (WBV) ameliorates neuronal behavioral effects chronic ethanol exposure. In this study, we employ a similar paradigm assess efficacy WBV preventative measure...
Gefapixant citrate (MK-7264) is a P2X3 antagonist for the treatment of chronic cough. The second generation manufacturing route developed Step 3A/3B formylation–cyclization reaction to generate key intermediate diaminopyrimidine (1) (AF-072) required significant excess ethyl formate (EF), potassium tert-butoxide (KOt-Bu), and guanidine•HCl (G•HCl) when both steps were run as batch processes. It was imperative develop an alternative process that less each reagent generated carbon monoxide...
Herein we describe the translation of an immobilized transaminase process in batch to a packed bed reactor for synthesis cyrene amine, intermediate Nemtabrutinib. This change design provided significant benefits both robustness enzyme preparation and minimization amount required perform transformation. The extended residence times high conversion led us investigate dynamic flow system quickly survey reaction kinetics under various conditions provide approximate pseudosteady state runs...
This paper is offered as a rejoinder to New Frontiers, Old Realities by Dr. Everett Carl Dolman, published in the Spring 2012 edition of Strategic Studies Quarterly. In it, Dolman portends, "[t]he coming war with China will be fought for control outer space." support this argument, he divines lessons history viewed through inseparable lenses neoclassical geopolitical theory and realist theory. The proposed solution disquieting nostrum advanced decade ago his book Astropolitik: Classical...
United States strategic export controls — which treat commercial satellite technologies, related technical data, and defense services as munitions subject to the strictest control criteria have been under fire for decades. Critics argue that in attempting bolster national security by limiting transfer of space technologies adversaries potential adversaries, U.S. has unintentionally paradoxically harmed undermining industrial base, academic research institutions feed grow international...
This article examines the current public discourse on sexual assault in military through complementary lenses of behavioral economics and law. The evaluates "crisis" narrative central to this suggests it is not supportable by best available data. Moreover, that driving potentially counterproductive policy initiatives, harmful victims assault. recommends several practical steps Department Defense might take near-term expose rebut forestall these initiatives. These include a reappraisal...
This paper discusses the widely-reported, yet unacknowledged, U.S. targeted killing program in Pakistan during 2009-2010 timeframe. It argues for an alignment of actions and rhetoric relation to this program.