A5093954867- Orthopedic Infections and Treatments
- Neurogenetic and Muscular Disorders Research
- Immune cells in cancer
- Craniofacial Disorders and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Amyotrophic Lateral Sclerosis Research
- Spinal Cord Injury Research
- S100 Proteins and Annexins
- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
Finceramica (Italy)
2025
University of Milan
2024-2025
Intensive research is dedicated to the development of novel biomaterials and medical devices be used as grafts in reconstructive surgery, with purpose enhancing their therapeutic effectiveness, safety, durability. A variety biomaterials, from autologous bone polymethylmetacrylate, polyether ether ketone, titanium, calcium-based ceramics are cranioplasty. Porous hydroxyapatite (PHA) reported a possible material for reconstruction, good signs biocompatibility, osteoconductive osteointegrative...
Abstract Background and Purpose Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron (MN) loss consequent muscle atrophy, for which no effective therapies are available. Recent findings reveal that disease progression fuelled early aberrant neuroinflammation the of oligodendrocytes with neuroprotective remyelinating properties. On this basis, pharmacological interventions capable restoring pro‐regenerative local milieu...
In neurosurgery, cranioplasty (CP) stands as a pivotal surgical intervention, particularly following head trauma or various neurosurgical interventions. This study scrutinizes the intricacies of CP, emphasizing its prevalence and associated complications, with specific focus on custom-made porous hydroxyapatite (PHA) implants. The investigation spans 687 patients (with 80 pediatric age, less than 14 years old) across 26 centers in five European countries. Methodologically, this delves into...
White matter damage and subsequent demyelination significantly contribute to long-term functional impairment after ischaemic stroke. Identifying novel pharmacological targets restore myelin integrity by promoting the maturation of oligodendrocyte precursor cells (OPCs) into new myelinating oligodendrocytes may open perspectives for stroke treatment. In this respect, previous studies highlighted role G protein-coupled membrane receptor 17 (GPR17) as a key regulator OPC differentiation in...