A5086210096- Reproductive Biology and Fertility
- Herpesvirus Infections and Treatments
- Sperm and Testicular Function
- Viral gastroenteritis research and epidemiology
- Plant Virus Research Studies
- RNA and protein synthesis mechanisms
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Genetics, Aging, and Longevity in Model Organisms
- Virus-based gene therapy research
- RNA modifications and cancer
- Plant and Fungal Interactions Research
- RNA Research and Splicing
- Transgenic Plants and Applications
- Animal Genetics and Reproduction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Research Institute of Molecular Pathology
2023-2024
The Netherlands Cancer Institute
2024
University of California, San Francisco
2009-2010
In response to excessive DNA damage, human cells can activate p53 induce apoptosis. Cells lacking still undergo apoptosis upon yet the responsible pathways are unknown. We observed that p53-independent in damage coincided with translation inhibition, which was characterized by ribosome stalling on rare leucine-encoding UUA codons and globally curtailed initiation. A genetic screen identified transfer RNAse SLFN11 kinase GCN2 as factors required for global respectively. Stalled ribosomes...
ABSTRACT Fertilization, the fusion of sperm and egg, is essential for sexual reproduction. While several proteins have been demonstrated to be binding gametes in vertebrates, molecular mechanisms driving this key process are poorly understood. Here, we performed a protein interaction screen using AlphaFold-Multimer uncover protein-protein interactions fertilization. This resulted prediction trimeric complex composed fertilization factors Izumo1 Spaca6, Tmem81, previously not implicated We...