A5104429064- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Genomics and Phylogenetic Studies
- Enzyme Production and Characterization
- Genetics, Bioinformatics, and Biomedical Research
Imperial College London
2024
Massachusetts Institute of Technology
2024
The advent of next-generation sequencing (NGS) has revolutionized the study single nucleotide polymorphisms (SNPs), making it increasingly cost-effective. Haplotypes, which combine alleles from adjacent variants, offer several advantages over bi-allelic SNPs, including enhanced information content, reduced dimensionality, and improved statistical power in genomic studies. These benefits are particularly significant for polyploid species, where distinguishing all homologous copies using SNP...
Phosphoglycosyl transferases (PGTs) are membrane proteins that initiate glycoconjugate biosynthesis by transferring a phospho-sugar moiety from soluble nucleoside diphosphate sugar to membrane-embedded polyprenol phosphate acceptor. The centrality of PGTs in complex glycan assembly and the current lack functional information make these enzymes high-value targets for biochemical investigation. In particular, small monotopic PGT family is exclusively bacterial represents minimal unit...
Phosphoglycosyl transferases (PGTs) are membrane proteins that initiate glycoconjugate biosynthesis by transferring a phospho-sugar moiety from soluble nucleoside diphosphate sugar to membrane-embedded polyprenol phosphate acceptor. The centrality of PGTs in complex glycan assembly and the current lack functional information make these enzymes high-value targets for biochemical investigation. In particular, small monotopic PGT family is exclusively bacterial represents minimal unit...