A5038688476- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroblastoma Research and Treatments
- Cerebrospinal fluid and hydrocephalus
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Epilepsy research and treatment
- Cancer Treatment and Pharmacology
- Acute Ischemic Stroke Management
- Management of metastatic bone disease
- Vascular anomalies and interventions
- interferon and immune responses
- Neonatal and fetal brain pathology
- Trauma and Emergency Care Studies
- Cancer, Hypoxia, and Metabolism
- Fetal and Pediatric Neurological Disorders
- Spinal Fractures and Fixation Techniques
- Cancer, Stress, Anesthesia, and Immune Response
- Genetic Neurodegenerative Diseases
- Psychosomatic Disorders and Their Treatments
- Hippo pathway signaling and YAP/TAZ
Washington University in St. Louis
2022-2025
Neurological Surgery
2025
With the recognition that noncancerous cells function as critical regulators of brain tumor growth, we recently demonstrated neurons drive low-grade glioma initiation and progression. Using mouse models neurofibromatosis type 1 (NF1)-associated optic pathway (OPG), showed Nf1 mutation induces neuronal hyperexcitability midkine expression, which activates an immune axis to support such high-dose lamotrigine treatment reduces Nf1-OPG proliferation. Herein, execute a series complementary...
Abstract Tissue injury and tumorigenesis share many cellular molecular features, including immune cell (T cells, monocytes) infiltration inflammatory factor (cytokines, chemokines) elaboration. Their common pathobiology raises the intriguing possibility that brain could create a tissue microenvironment permissive for tumor formation. Leveraging several murine models of Neurofibromatosis type 1 (NF1) cancer predisposition syndrome two experimental methods injury, we demonstrate both optic...
OBJECTIVE Although targeted systemic therapies and postoperative radiation therapy (RT) have improved outcomes in patients with metastatic breast cancer, how treatment combinations impact spine surgery remains understudied. In undergoing for the authors sought to do following: 1) describe patterns of therapy; 2) report perioperative outcomes; 3) evaluate plan on local recurrence (LR) overall survival (OS). METHODS A dual-institution, retrospective cohort study cancer was undertaken. Patients...
Background: Type 1 basilar invagination (BI) is caused by a structural instability at the craniovertebral junction (CVJ) and has been historically treated with distraction stabilization through fusion of C1-C2 vertebrae. Recent advances in 3D printed custom implants (3DPI) have improved array available options for reaching alignment goals. Case Presentation: We report case 15-year-old male who presented early signs cervical myelopathy. Radiographic evaluation revealed type BI widened...
Abstract Background CSF has long been accepted to circulate throughout the subarachnoid space, which lies between arachnoid and pia maters of meninges. How interacts with cellular components developing postnatal meninges including dura, arachnoid, both at surface brain intracranial meninges, prior its eventual efflux from cranium spine, is less understood. Here, we characterize small large solute distribution patterns along in neonatal rodents compare our findings meningeal a rodent model...
Abstract Brain tumors arise in close association with neurons, suggesting that these non-neoplastic cells may be critical stromal drivers of brain tumor initiation and growth. Previously, we have shown murine low-grade optic glioma formation progression the setting Neurofibromatosis type 1 (NF1) is dictated by neurons neuronal activity. In studies, dependencies reflected activity-driven enzymatic cleavage a growth factor (neuroligin-3) from oligodendrocyte precursors (tumor initiation) or...
Background: Neurologic patients transferred to an intensive care unit (ICU) have increased length of stays, mortality, and healthcare cost. There is limited data regarding incident transfers in stroke-specific cohorts. We sought identify clinical features, transfer timing, outcomes admitted with ischemic stroke who required ICU escalation. Methods: identified all age >18 our institution a principle diagnosis between 2016 2019. included requiring at any point their hospitalization....
Abstract Background The recent characterization of the glymphatic system and meningeal lymphatics has re-emphasized role meninges in facilitating CSF transport clearance. Here, we characterize small large solute distribution patterns along intracranial surface neonatal rodents compare our findings to a rodent model intraventricular hemorrhage-posthemorrhagic hydrocephalus. We also examine interactions with tela choroidea its pial invaginations into choroid plexuses lateral, third, fourth...
Abstract While neuronal activity has previously been implicated in malignant glioma growth control, we recently demonstrated that neuron excitability can also regulate low-grade (optic) initiation and progression. In this prior study, showed NF1 germline mutation-dependent sustains optic through HCN channel-mediated midkine activation of a T cell-microglia stromal circuit. Relevant to clinical translation, lamotrigine modulation channel function reduced hyperexcitability, production (OPG)...
Painful Hand Seizures are a rarely reported form of secondary sensory seizures (SSS) characterized by painful, bilateral sensorimotor hand involvement and preserved consciousness. We report our case to aid neurologists in recognizing SSS as an atypical presentation seizures.