A5100605109- Glioma Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Neuroblastoma Research and Treatments
- MicroRNA in disease regulation
- Neurofibromatosis and Schwannoma Cases
- Neuroinflammation and Neurodegeneration Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Meningioma and schwannoma management
- Cancer, Stress, Anesthesia, and Immune Response
- Histiocytic Disorders and Treatments
- Blood groups and transfusion
- Cancer-related molecular mechanisms research
- Blood transfusion and management
- RNA Interference and Gene Delivery
- Pluripotent Stem Cells Research
- Immune cells in cancer
- Parvovirus B19 Infection Studies
- Blood disorders and treatments
University of California, Los Angeles
2022-2024
Johns Hopkins University
2012-2021
Johns Hopkins Medicine
2020-2021
NYU Langone Health
2012
Sidney Kimmel Comprehensive Cancer Center
2012
Washington University in St. Louis
2010-2012
Mayo Clinic
2005-2012
Whereas carcinogenesis requires the acquisition of driver mutations in progenitor cells, tumor growth and progression are heavily influenced by local microenvironment. Previous studies from our laboratory have used Neurofibromatosis-1 (NF1) genetically engineered mice to characterize role stromal cells signals optic glioma formation growth. Previously, we shown that Nf1+/- microglia microenvironment critical cellular determinants proliferation. To define maintenance further, CD11b-TK mice,...
Pilocytic astrocytoma (PA) is a World Health Organization grade I glioma that occurs most commonly in children and young adults. Specific genetic alterations have been described PA, but the pathogenesis remains poorly understood. We studied microRNA (miRNA) large cohort of patients with PA. A total 43 including 35 sporadic 4 neurofibromatosis-1 (NF1)–associated PA pilomyxoid features, as well 5 nonneoplastic brain controls were examined. BRAF fusion status was assessed cases. RNA examined...
Abstract A major obstacle to identifying improved treatments for pediatric low-grade brain tumors (gliomas) is the inability reproducibly generate human xenografts. To surmount this barrier, we leveraged induced pluripotent stem cell (hiPSC) engineering gliomas (LGGs) harboring two most common pilocytic astrocytoma-associated molecular alterations, NF1 loss and KIAA1549:BRAF fusion. Herein, identified that hiPSC-derived neuroglial progenitor populations (neural progenitors, glial restricted...
Abstract Pediatric low-grade gliomas (pLGGs) are the most common brain tumor in young children. While they typically associated with good overall survival, children these central nervous system tumors often experience chronic tumor- and therapy-related morbidities. Moreover, individuals unresectable frequently have multiple recurrences persistent neurological symptoms. Deep molecular analyses of pLGGs reveal that caused by genetic alterations converge on a single mitogenic pathway (MEK/ERK),...
Hemophagocytic lymphohistiocytosis (HLH) is an infrequent inflammatory multisystemic syndrome. Only rare cases with ophthalmic involvement describing their pathologic features have been previously reported.We report 3 of adult-onset HLH bilateral ocular and describe clinicopathologic features.Three adult males - 2 a history viral infection developed persistent fever, fatigue, bone marrow abnormalities, irreversible multiorgan failure. Visual impairment was also documented in cases. Complete...
ABSTRACT Nervous system tumors, particularly brain represent the most common tumors in children and one of lethal adults. Despite decades research, there are few effective therapies for these cancers. Although human nervous tumor cells genetically engineered mouse models have served as excellent platforms drug discovery preclinical testing, they limitations with respect to accurately recapitulating important aspects pathobiology spontaneously arising tumors. For this reason, attention has...
Abstract Brain tumors arise in close association with neurons, suggesting that these non-neoplastic cells may be critical stromal drivers of brain tumor initiation and growth. Previously, we have shown murine low-grade optic glioma formation progression the setting Neurofibromatosis type 1 (NF1) is dictated by neurons neuronal activity. In studies, dependencies reflected activity-driven enzymatic cleavage a growth factor (neuroligin-3) from oligodendrocyte precursors (tumor initiation) or...
Abstract Genomic profiling often fails to predict therapeutic outcomes in cancer. This failure is, part, due a myriad of genetic alterations and the plasticity cancer signaling networks. Functional profiling, which ascertains dynamics, is an alternative method anticipate drug responses. It unclear whether integrating genomic functional features solid tumours can provide unique insight into vulnerabilities. We perform combined molecular characterization, via BH3 intrinsic apoptotic machinery,...