A5024754812- Protein Hydrolysis and Bioactive Peptides
- Biochemical effects in animals
- Gout, Hyperuricemia, Uric Acid
- Computational Drug Discovery Methods
- RNA and protein synthesis mechanisms
- Free Radicals and Antioxidants
- Helicobacter pylori-related gastroenterology studies
- Crystallography and molecular interactions
- Nuclear Structure and Function
- GDF15 and Related Biomarkers
- Ginseng Biological Effects and Applications
- Diet and metabolism studies
- Pharmacological Effects of Natural Compounds
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
- Botanical Research and Chemistry
- Phytochemistry and Bioactivity Studies
- Enzyme Structure and Function
- Tryptophan and brain disorders
- Biochemical Analysis and Sensing Techniques
- Ferroptosis and cancer prognosis
- Drug Transport and Resistance Mechanisms
- Laser Applications in Dentistry and Medicine
- Galectins and Cancer Biology
- Glioma Diagnosis and Treatment
South China University of Technology
2019-2025
Decreasing β-amyloid (Aβ) accumulation is of significance in finding therapeutic candidates for cognitive impairments Alzheimer's disease (AD). The aim this study to investigate the potency active components walnut protein decreasing Aβ aggregation and ameliorating impairments.Cell model intracellular Aβ42 used explore ingredients hydrolysate (WPH). A bioactive peptide (Pro-Pro-Lys-Asn-Trp, PW5) with great anti-Aβ42 activity identified from WPH synthesized vitro vivo experiments. Using...
Gastric cancer (GC) has high morbidity and mortality rates worldwide. Abundant literature reported several individual genes their related pathways intimately involved in tumor progression. However, little is known about GC progression at the gene network level. Therefore, understanding underlying mechanisms of pathological transition from early stage to late urgently needed. This study aims identify potential vital modules GC. To understand regulatory progression, we analyzed micro RNAs...
Breast cancer patients undergoing chemotherapy often experience muscle wasting and weakness, which impact their quality of life. A potential solution lies in customizing amino acid compositions based on exome-derived formulations (ExAAs). The study hypothesized that tailoring dietary acids using ExAAs could enhance health. Theoretical requirements were calculated from the genome's exome region, a breast mouse model paclitaxel treatment was established. mice supplemented with cancer-specific...
Inhibiting β ‐amyloid (A ) aggregation is of significance in finding potential candidates for Alzheimer's disease (AD) treatment. Accumulating evidence suggests that nutrition important improving cognition and reducing AD risk. Walnut has been widely used as a functional food brain health; however the underlying mechanisms remain unknown. Here, we investigated molecular level alteration Arctic mutant A 42 induced cell model by RNA‐seq iTRAQ approaches after walnut‐derived peptides...
One of the main reasons for hyperuricemia is high purine intake. The primary strategy treating blocking metabolism enzyme. However, by binding bases directly, we suggested a unique therapeutic that might interfere with metabolism. There have been numerous reports extensive interactions between proteins and bases. Adenine, which component protein co-factors, can interact adenine-binding motif. Using Bayesian Inference Markov chain Monte Carlo sampling, created novel peptide Ile-Tyr-Val-Thr...