A5103188972- Pneumocystis jirovecii pneumonia detection and treatment
- Neurogenetic and Muscular Disorders Research
- Acute Myeloid Leukemia Research
- Tuberculosis Research and Epidemiology
- Acute Lymphoblastic Leukemia research
- Muscle Physiology and Disorders
- Pneumonia and Respiratory Infections
- RNA modifications and cancer
- Retinoids in leukemia and cellular processes
- Cardiomyopathy and Myosin Studies
- HIV/AIDS drug development and treatment
- Eosinophilic Disorders and Syndromes
- Synthesis and Biological Evaluation
- Marine and fisheries research
- Drug-Induced Adverse Reactions
- Hematopoietic Stem Cell Transplantation
- Cancer Research and Treatments
- Occupational and environmental lung diseases
- Congenital Anomalies and Fetal Surgery
- Endometrial and Cervical Cancer Treatments
- Epigenetics and DNA Methylation
- Occupational Health and Performance
- Mechanical Circulatory Support Devices
- Water-Energy-Food Nexus Studies
- Property Rights and Legal Doctrine
Ideaya Biosciences (United States)
2025
University of Minnesota
2023
Samumed (United States)
2021
Winthrop-University Hospital
2020
Kadlec Clinic
2010
Thomas Jefferson University
2002
University of Cincinnati
1979-2000
Veterans Health Administration
1992-1997
Cincinnati VA Medical Center
1994
University of Cincinnati Medical Center
1979-1994
To assess the efficacy and safety of R788 (fostamatinib disodium), an inhibitor spleen tyrosine kinase (Syk), in patients with active rheumatoid arthritis (RA) that did not respond to biologic therapies.A total 219 RA whom treatment agents had failed were enrolled a 3-month multicenter, randomized, double-blind, placebo-controlled trial R788. The primary end point was percentage who met American College Rheumatology 20% improvement criteria (achieved ACR20 response) at month 3. Secondary...
The course of spinal muscular atrophy (SMA) is not well established except for those patients whose age onset before 6 months and who achieve only "sit with support" as their maximum function (Werdnig-Hoffmann disease or SMA I). This study shows that there another group achieved can be used prognostic guides. Fifty percent could walk without assistance was prior to 2 years lost the ability independently by 12. walked between walking 44 years. best ever this 7 years, unrelated onset; none...
We have established the first prospective, collaborative study of spinal muscular atrophy, second most common neuromuscular disease childhood. One hundred and forty-one patients been evaluated on at least four occasions over a 3-year period. The grouped by age onset, as well function time initial evaluation. muscle strength 96 aged 5 years or older was 6-month intervals using fixed myometry system. new observations made are: (1) present classification schema is not valid; for example, 49...
Spinal muscular atrophy is a genetic disorder of the motor neurons that causes profound hypotonia, severe weakness, and often fatal restrictive lung disease. Patients with spinal present spectrum disease from most infantile-onset type, called Werdnig-Hoffmann (type 1), associated mortality rate up to 90%, late-onset mild form 3), wherein patients remain independently ambulatory throughout adult life. Although many clinicians agree lose abilities age, it unknown whether progressive weakness...
The efficacy of antifolate, antiviral, and other drugs was compared in an experimental model pneumocystosis. Sulfamethoxazole (SMX) administered alone doses greater than or equal to 60 mg/kg/day highly effective treatment prophylaxis. Low (less 15 mg/kg/day) SMX showed limited, dose-related anti-Pneumocystis carinii activity therapy but were more dihydrofolate reductase (DHFR) inhibitors trimethoprim (TMP), pyrimethamine, trimetrexate exhibited little anti-P. when did not enhance the SMX;...
We present the first prospective study on pulmonary function in spinal muscular atrophy patients. Seventy-seven patients, ages 5 to 18 years, from three centers, were studied with regard forced vital capacity, using height as a predictor. Patients categorized into four motor categories. The highest-functioning group had normal or near-normal values, and those who sat support lowest values. Those intermediate Forced capacity was longitudinally 40 patients for 1.1 4.4 years. Eighty-eight...
To detect whether there was geographic clustering of Pneumocystis carinii pneumonia cases among patients with human immunodeficiency virus (HIV) infection, we performed a retrospective analysis clinical database. The rates pneumocystosis were analyzed by zip code zones for evidence geographical clustering. During the study period, 118 at our AIDS Treatment Center had first episode P. pneumonia. An 24 which rate calculated (requiring denominator least 10 known HIV- infected individuals...
We compared Ro 11-8958, an analog of trimethoprim (TMP) with improved antimicrobial and pharmacokinetic properties, other dihydrofolate reductase (DHFR) inhibitors, sulfamethoxazole (SMX), dapsone (DAP) in the treatment Pneumocystis carinii pneumonia immunosuppressed rat model. In contrast to previous reports, high dosages DHFR inhibitors were used combination fixed, low SMX (3 mg/kg body weight per day) or DAP (25 mg/kg/day). When administered alone at these dosages, reduced median P. cyst...
Bromodeoxyuridine (BrdU) was administered to 128 newly diagnosed patients with standard risk acute myelocytic leukaemia (AML) for cell cycle measurements. Labelling indices (LI) were obtained from both the bone marrow aspirate (BMasp) and biopsies (bx) durations of S‐phase ( T s ) total time c measured by double‐labelling cells in vitro tritiated thymidine. Median LI BMasp 8% BMbx 25%. The median 12 h (range 3·1–35 h) 48 11·5–211 h). All received induction therapy a combination cytosine...
Congenitally immunodeficient and immunosuppressed normal mice with naturally acquired Pneumocystis carinii infection were compared as models for testing anti-P. drugs. Among the mice, severe combined immunodeficiency disease (scid), which lack B T cells, had higher levels of P. pneumonia than did microMT K cells. Normal administered dexamethasone in drinking water more extensive pneumocystosis parenteral methylprednisolone or hybridoma cells making a monoclonal antibody to CD4 The standard...
Objectives We examined 96 bronchoalveolar lavage fluid (BALF) specimens from AIDS patients with proven Pneumocystis carinii pneumonia (PCP) in order to compare the relationship of organism burden, viability and antigen expression disease severity at time clinical presentation. Methods Tinctorial analysis BALF PCP using Diff-Quik, cresyl echt violet erythrosin B stains evaluate burden viability. P. examination was performed by Western blot analysis. Results cluster ratios were more sensitive...
More than 40 leading US agricultural and water scientists developed a research vision designed to address the most critical challenges in changing climate sustain production natural systems. Water sustainability can only be realized by balancing
Abstract Bromodeoxyuridine (BrdU) was administered to 86 newly diagnosed patients with standard risk acute myeloid leukemia (AML) prior starting induction therapy and the labeling index (LI), durations of S‐phase (Ts), cell cycle (Tc) myeloblasts were determined. Induction cytosine arabinoside daunomycin subsequently started. Bone marrow biopsies obtained on days 6 17 weekly thereafter, treated a monoclonal anti‐BrdU antibody determine fate cells labeled day 0 by BrdU. BrdU granulocytes...
We previously reported that patients with spinal muscular atrophy do not lose muscle strength over time as measured quantitatively. However, we noted many suffer from what they called fatigue. wondered if could measure fatigue during a single maximal voluntary contraction, whether might increase time, independent of strength, and increasing correlate loss function in some patients. contraction cohort having using quantitative testing. included only aged 5 years or older, so follow...
The objective of this study was to determine the response rate and toxicity high-dose cytosine arabinoside (AC) mitoxantrone (M) in relapsed or refractory childhood acute myeloid leukemia (AML) lymphocytic (ALL) correlate with expression multidrug resistance gene 1 (mdr1). Twenty-nine patients were treated AC 1.0 g/m2 infused over 2 h every 12 for eight doses (days 1-4) M mg/m2 3-6). Mdr1 determined by a polymerase chain reaction (pcr) assay. Ten 15 (67%) AML obtained complete remission (CR)...
Guanylhydrazones are cationic heteroaromatic drugs similar to the diamidines which effective in treatment of African trypanosomiasis and pneumocystosis. On basis their antitrypanosomal activity, different guanylhydrazones were selected for evaluation a rat model Pneumocystis carinii pneumonia. The most active compounds 2-(4'-formylphenyl)-1-methylimidazo-[1,2-a] pyridinium which, at dose 2 mg/kg/day, about as trimethoprim-sulfamethoxazole 50 mg trimethoprim per kg/day plus 250...
We analyzed single drugs and combinations of used clinically in the treatment opportunistic infections other conditions for their activities against Pneumocystis carinii pneumonia immunosuppressed rats. When they were alone, atovaquone, rifabutin, dapsone more active than clarithromycin or trimethoprim. Drug evaluated synergistic activity by an analysis variance model two-way factorial experiments a response surface model. Atovaquone combined with trimethoprim some was synergistic; however,...
Abstract Dysregulation of alternative pre-mRNA splicing has been identified as a common mechanistic driver tumor initiation, disease progression, and emergence therapy resistance. An iterative screening campaign SM08502, potent pan-inhibitor CDC-like kinases (CLKs), which are known to regulate splicing. In preclinical studies, SM08502 inhibited growth induced apoptosis in broad array models. Study NCT03355066 is two-part Phase 1 first-in-human study that evaluated the safety, tolerability,...
Identifying remediable causes of occupant symptoms in building-related illness is frequently difficult. This particularly true when the building-wide prevalence comparable to that reported non-problem buildings. analysis applied an epidemiological approach assessment a problem building, allowing investigators visually identify area apparent increased symptom density. A cluster permitted biostatistical confirmation visual cluster. Building-related reporting was statistically significantly...