A5017716902- Eating Disorders and Behaviors
- Obesity, Physical Activity, Diet
- Child and Adolescent Psychosocial and Emotional Development
- Lipid metabolism and biosynthesis
- Photosynthetic Processes and Mechanisms
- Sphingolipid Metabolism and Signaling
- Molecular Junctions and Nanostructures
- Enzyme Structure and Function
- Behavioral Health and Interventions
- Biochemical and Molecular Research
- Protein Structure and Dynamics
- Traumatic Brain Injury Research
- Psychosocial Factors Impacting Youth
- Glycosylation and Glycoproteins Research
- Child and Adolescent Health
- Child Nutrition and Feeding Issues
- Family and Disability Support Research
- Peptidase Inhibition and Analysis
- Autism Spectrum Disorder Research
- Plant biochemistry and biosynthesis
- Counseling Practices and Supervision
- Adenosine and Purinergic Signaling
- Behavioral and Psychological Studies
- Lipid Membrane Structure and Behavior
- Adipose Tissue and Metabolism
University of Fribourg
2023-2025
Duke Medical Center
2005
Duke University Hospital
2005
University at Buffalo, State University of New York
2000
James Madison University
2000
The dynamic addition and removal of long-chain fatty acids modulate protein function localization. α/β hydrolase domain-containing (ABHD) 17 enzymes remove acyl chains from membrane-localized proteins such as the oncoprotein NRas, but how ABHD17 are regulated is unknown. Here, we used cell-based studies molecular dynamics simulations to show that activity controlled by two mobile elements-an S-acylated N-terminal helix a loop-that flank putative substrate-binding pocket. Multiple S-acylation...
A six-session eating disorder prevention program was completed with three samples: middle school, high and college females. The intended to promote resiliency factors while mitigating risk that had been identified earlier by hierarchical multiple regression analyses subsequent path from a large epidemiological sample (Phelps, Johnston, & Augustyniak, 1999). Utilizing this etiological model, the successful in: (a) facilitating an acknowledgement of ubiquitous pressures for attainment model...
Lipid droplets (LDs) are ubiquitous intracellular organelles with a central role in multiple lipid metabolic pathways. However, identifying correlations between their structural properties and biological activity has proved challenging, owing to unique physicochemical as compared other cellular membranes. In recent years, molecular dynamics (MD) simulations, computational methodology allowing the accurate description of assemblies down individual components, have been demonstrated be useful...
Abstract The dynamic addition and removal of long chain fatty acids modulates protein function localization. alpha/beta hydrolase domain-containing (ABHD) 17 enzymes remove acyl chains from membrane localized proteins such as the oncoprotein NRas, but how ABHD17 are regulated is unknown. Here, we used cell-based studies molecular dynamics simulations to show that activity controlled by two mobile elements – an S-acylated N-terminal helix a loop flank substrate-binding pocket. S-acylation at...
Abstract The prevalence of eating disorders and associated health risks, morbidity, mortality renders prevention programming an urgent care need. Growing awareness the pervasiveness scope problem on college campuses has resulted in development treatment models. However, few studies examine efficacy this programming. Utilizing a sociocultural model for etiology disorders, research compared no-treatment group differences 80 undergraduate women. four-session intervention was intended to reduce...
Complex genetic and dietary cues contribute to the development of obesity, but how these are integrated on a molecular level is incompletely understood. Here, we show that PPARγ supports hypertrophic expansion adipose tissue via transcriptional control LPCAT3, membrane-bound O-acyltransferase enriches diet-derived omega-6 (