About
Contact & Profiles
A5102930297
Research Areas
- Protein Degradation and Inhibitors
- Monoclonal and Polyclonal Antibodies Research
- Ubiquitin and proteasome pathways
Yale University
2024
We recently developed a heterobifunctional approach [phosphorylation targeting chimeras (PhosTACs)] to achieve the targeted protein dephosphorylation (TPDephos). Here, we envisioned combining inhibitory effects of receptor tyrosine kinase inhibitors (RTKIs) and active by phosphatases dual inhibition kinases. report an example phosphatase–based TPDephos effective epidermal growth factor (EGFR) dephosphorylation. also used phosphoproteomic approaches study signaling transductions affected...
10.1126/sciadv.adj7251
article
EN
cc-by-nc
Science Advances
2024-03-27
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