A5009223610- Bone and Dental Protein Studies
- Bacteriophages and microbial interactions
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Virology and Viral Diseases
- Natural Compounds in Disease Treatment
- Liver Disease Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Viral Infections and Immunology Research
- Cell Adhesion Molecules Research
- Digestive system and related health
- Radiopharmaceutical Chemistry and Applications
- Respiratory viral infections research
- Aldose Reductase and Taurine
- Immune cells in cancer
- interferon and immune responses
- Nigella sativa pharmacological applications
- Virus-based gene therapy research
- Monoclonal and Polyclonal Antibodies Research
- Chemokine receptors and signaling
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Inflammatory mediators and NSAID effects
- Cytokine Signaling Pathways and Interactions
Lanzhou Veterinary Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
Lanzhou University
2024
Yunnan Center for Disease Control And Prevention
2023
Wuhan University
2023
Renmin Hospital of Wuhan University
2023
Thomas Jefferson University
2005-2012
Loss of β-catenin homeostasis is tightly associated with human malignancies, modulation stabilization could be an attractive strategy for cancer therapy. In the present study, we demonstrated that ancient drug curcumin was selective accumulation phosphorylated (PBC) tagged both ubiquitin (Ub) and Ub-like (Ubl) protein NEDD8. We further identified USP14, a deubiquitinating enzyme (DUB) in 19S proteasome, as functional target modulating β-catenin. Curcumin enhances USP14-mediated PBC trapping...
Osteopontin (OPN) is a secreted acidic phosphoprotein that binds to cell-surface integrin-binding motif and involved in many inflammatory immune-modulating disorders. There compelling evidence soluble OPN can variety of situations help cells survive an otherwise lethal insult. In this study we show localized the rat pancreatic islets ducts. Staining serial sections with islet hormone antibodies showed all express OPN. Rats treated single dose streptozotocin (STZ; 50 mg/kg) acute upregulation...
Foot-and-mouth disease (FMD) is a highly contagious and economically important of cloven-hoofed animals that hampers trade production. To ensure effective infection, the foot-and-mouth virus (FMDV) evades host antiviral pathways in different ways. Although effect histone deacetylase 5 (HDAC5) on innate immune response has previously been documented, precise molecular mechanism underlying HDAC5-mediated FMDV infection not yet clearly understood. In this study, we found silencing or knockout...
Objective: To investigate the expression of glycolytic genes in immune cells and changes related experimental autoimmune neuritis (EAN), deepen understanding pathogenesis EAN. Methods: Twenty-four male C57BL/6 mice (6-8 weeks old, 18-20 g) were divided into four groups according to random number table method: control group (P0180-199 was replaced by PBS during modeling sacrificed on 16th day), EAN 8th day after end (EAN 8 d), 16 received drug intervention (2-DG intraperitoneally injected...
Objective: To understand the genotype distribution and transmission pattern of rubella virus (RuV) circulating in Yunnan Province. Methods: Throat swab samples were collected from outbreaks sporadic cases nine prefectures/cities Province 2011 to 2021. Virus isolation, amplification target genes sequence determination performed on RuV-positive samples. The genotypes lineages strains determined by comparing them with reference strains, further phylogenetic analysis was other provinces China...