A5023271219- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Plant biochemistry and biosynthesis
- TGF-β signaling in diseases
- Food Chemistry and Fat Analysis
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Hepatitis B Virus Studies
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Hippo pathway signaling and YAP/TAZ
- Edible Oils Quality and Analysis
- RNA modifications and cancer
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Free Radicals and Antioxidants
- Metabolomics and Mass Spectrometry Studies
- Coconut Research and Applications
- Lignin and Wood Chemistry
- Renal and related cancers
- Mycobacterium research and diagnosis
- Genomics and Chromatin Dynamics
- Lipid metabolism and biosynthesis
- Thermal and Kinetic Analysis
Indiana University Bloomington
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Hainan University
2024
Indiana University School of Medicine
2024
TP53 is one of the most frequently mutated genes among all cancer types, and mutants occur more than 60% in colorectal (CRC). Among mutants, there are three hot spots, including p53-R175H, p53-R248W p53-R273H. Emerging evidence attributes carcinogenesis to stem cells (CSCs). Long noncoding RNAs (lncRNAs) play crucial roles maintaining stemness CSCs. However, it unknown if mutant p53-regulated lncRNAs implicated maintenance CSC stemness.RNA-sequencing (RNA-seq) ChIP-sequencing (ChIP-seq) were...
Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), mostly characterised by HBV integrations, is prevalent worldwide. Previous studies mainly focused on a few hotspot integrations. However, the oncogenic role of other integrations remains unclear. This study aimed to elucidate integration-induced tumourigenesis further.
Poly (ADP-ribose) polymerase inhibitors (PARPis) are an important treatment modality for homologous recombination deficient (HRD) cancers, including high grade serous ovarian cancer (HGSOC). PARP mediates DNA single-strand break (SSB). PARPis trap at the site of SSB and prevent repair, which eventually leads to double-strand breaks (DSBs). DSBs normally repaired through HR pathway, highly efficient in HRD disease. However, majority HGSOC proficient (HRP), use patients with HRP tumors...
The persistence of cancer stem cells (CSC) is believed to contribute resistance platinum-based chemotherapy and disease relapse in ovarian cancer, the fifth leading cause cancer-related death among US women. HOXC transcript antisense RNA (HOTAIR) a long, noncoding (lncRNA) overexpressed high-grade serous linked chemoresistance. However, HOTAIR impacts chromatin dynamics CSCs. Oncogenic lncRNA's contributions drug-resistant are incompletely understood. Here, we generated knockout (KO) cell...
α-Tthalassemia mental retardation X-linked (ATRX) is a chromatin remodeler frequently mutated in many cancers. Despite the binding pattern of ATRX heterochromatin, ATRX-mediated epigenomic changes cancer cells have not been profiled, especially for heterochromatin regions. Here, we profiled genome-wide maps accessibility ATRX-intact and ATRX-null human cells. We found extensive both repetitive DNA regions non-repetitive regulatory following loss. These are highly correlated with...
Smad2 and Smad3 (Smad2/3) are structurally similar proteins that primarily mediate the transforming growth factor-β (TGF-β) signaling responsible for driving cell proliferation, differentiation, migration. The dynamics of Smad2/3 phosphorylation provide key mechanism regulating TGF-β pathway, but details surrounding this remain unclear. Here, using in vitro kinase assay coupled with mass spectrometry, we identified first time nemo-like (NLK) regulates via modulation linker region....
Background Aroma significantly influences the quality of rambutan seed oil. Nonetheless, few studies have examined volatile composition Thus, there is a need for comprehensive characterization aroma profile Methods This study systematically investigated and compared characteristics three types (BR-4, BR-5 BR-7) oils using HS-SPME-GC-MS HS-GC-IMS techniques, augmented by chemometric modeling. Results GC-MS identified 135 compounds, primarily hydrocarbons esters, while GC-IMS characterized 35...
A foodomics approach was employed to systematically characterize and compare the quality parameters, antioxidant activity, minor-components, fatty acid composition, lipid profiles of seed oils from three most popular rambutan varieties in China. The total content ranged 23.40 25.77 g/100 g. acids 9cC18:1 (39.84%-40.92%) C20:0 (28.45%-30.23%) were identified as dominant ones, which are uncommon among higher plants. All oil samples exhibited low AI TI values. BR-7 highest levels squalene...
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<div>Abstract<p>The persistence of cancer stem cells (CSC) is believed to contribute resistance platinum-based chemotherapy and disease relapse in ovarian cancer, the fifth leading cause cancer-related death among US women. HOXC transcript antisense RNA (HOTAIR) a long, noncoding (lncRNA) overexpressed high-grade serous linked chemoresistance. However, HOTAIR impacts chromatin dynamics CSCs. Oncogenic lncRNA’s contributions drug-resistant are incompletely understood. Here, we...