A5001704983- Viral Infectious Diseases and Gene Expression in Insects
- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- HIV Research and Treatment
- Analytical chemistry methods development
- Synthesis and Characterization of Heterocyclic Compounds
- Electrochemical Analysis and Applications
- Synthetic Organic Chemistry Methods
- HIV/AIDS drug development and treatment
- Enzyme Catalysis and Immobilization
- Protein Interaction Studies and Fluorescence Analysis
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Microbial Metabolic Engineering and Bioproduction
- Radioactivity and Radon Measurements
- Soil Carbon and Nitrogen Dynamics
- Inorganic and Organometallic Chemistry
- Fatty Acid Research and Health
- Toxin Mechanisms and Immunotoxins
- Catalytic Cross-Coupling Reactions
- Chemical Synthesis and Reactions
- Advanced Synthetic Organic Chemistry
- Organoboron and organosilicon chemistry
- Various Chemistry Research Topics
- Analytical Chemistry and Chromatography
Instituto de Química Médica
2014-2019
Consejo Superior de Investigaciones Científicas
2011-2015
Instituto de Química Física Blas Cabrera
2011
Universidad de Valladolid
2005-2006
Universidad de León
1991-1996
Thioglycosides offer the advantage over O-glycosides to be resistant hydrolysis. Based on initial evidence of this recognition ability for glycosyldisulfides by screening dynamic combinatorial libraries, we have now systematically studied dithiodigalactoside a plant toxin (Viscum album agglutinin) and five human lectins (adhesion/growth-regulatory galectins with medical relevance e.g. in tumor progression spread). Inhibition assays surface-presented neoglycoprotein solution monitored...
Abstract Herein we describe a class of unconventional nucleosides (methyloxynucleosides) that combine nucleobases such as substituted aminopyrimidines, aminopurines, or aminotriazines with unusual sugars in their structures. The allitollyl altritollyl derivatives were pursued ribonucleoside mimics, whereas the tetrahydrofuran analogues dideoxynucleoside analogues. compounds showed poor, if any, activity against broad range RNA and DNA viruses, including human immunodeficiency virus (HIV)....
[reaction: see text] Epoxyallylsilanes bearing the bulky tert-butyldiphenylsilyl group undergo an uncommon tandem rearrangement-cyclization process upon treatment with Lewis acids. Two pathways for carbonyl ene reaction are observed: one leading to allylsilane-cyclohexanols when epoxyallylsilane (28-31) is nonsubstituted, 2-, or 4-monosubstituted and other vinylsilane-cyclohexanols (24-27) 2,4-disubstituted trisubstituted. An explanation observed regio- stereoselectivity advanced a reliable...
The adsorption of soluble inorganic mercury ions from aqueous solutions on the external membrane both lyophilized bacterial cells and living was studied as a function solution pH, time, amount adsorbent, concentration ions, sample volume. Desorption studies were also performed using types cells. Loaded membranes unadsorbed measured by electrothermal atomic absorption spectrometry (ETAAS) and/or gamma spectrometry. 203Hg radiotracer (t1/2= 46.6 d) used to monitor recoveries in process adapted...
Foot-and-mouth disease virus (FMDV) is an RNA belonging to the Picornaviridae family that contains three small viral proteins (VPgs), named VPg1, VPg2 and VPg3, linked 5'-end of genome. These VPg act as primers for replication, which initiated by consecutive binding two UMP molecules hydroxyl group Tyr3 in VPg. This process, termed uridylylation, catalyzed RNA-dependent polymerase 3Dpol. 5-Fluorouridine triphosphate (FUTP) a potent competitive inhibitor uridylylation. Peptide analysis showed...
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharge transfer in Lewis acid-base reactions: A MO study of the H3+ systemG. M. Fernandez , J. A. Sordo and T. L. Cite this: Chem. Educ. 1989, 66, 11, 898Publication Date (Print):November 1, 1989Publication History Received3 August 2009Published online1 November 1989Published inissue 1 1989https://doi.org/10.1021/ed066p898RIGHTS & PERMISSIONSArticle Views159Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are COUNTER-compliant sum full...