An efficient and direct synthesis of 2-arylideneamino-3-aryl-4H-furo[3,2-c]chromen-4-ones has been developed via four-component reaction from substituted nitrostyrenes, aromatic aldehydes, coumarins, ammonium acetate under very mild conditions, which involves sequentially a Michael addition, an aza-nucleophilic the imine to double bond, intermolecular nucleophilic addition dehydration reaction. The resulting biologically intriguing structures could have broad applications in related...

Abstract A straightforward and efficient iodine‐promoted ring‐opening/cyclization domino reaction of 1‐cyanocyclopropane 1‐esters for the synthesis fully substituted 2‐aminofurans is reported. This involves sequential ring‐opening/intramolecular cyclization to give corresponding 2‐amino‐4,5‐dihydrofurans, which were oxidized with I 2 Et 3 N in refluxing toluene 2‐amino‐3‐furancarboxylates. magnified image

An efficient and straightforward synthetic protocol has been developed for the diversity-oriented synthesis of highly functionalized piperidines containing a Meldrum's acid moiety via pseudo five-component reaction between aromatic aldehydes, ammonium acetate, substituted β-nitrostyrenes generation wide range structurally interesting pharmacologically significant compounds.

An efficient and straightforward the preparation of 6-carbamoylfulvene-6-carboxylates <italic>via</italic> a cycloaddition reaction between 1-cyanocyclopropane 1-ester β-nitrostyrenes.

The diversity-oriented synthesis of pyrrolo[3,4-<italic>c</italic>]coumarins <italic>via</italic> FeCl₃-promoted three component reaction between substituted 2-(2-nitrovinyl)phenols, acetylenedicarboxylate and amines has been developed.

The diversity-oriented synthesis of naphtho[<italic>b</italic>]furans<italic>via</italic>a four-component reaction between naphthanols, substituted β-nitrostyrenes, benzaldehydes and ammonium acetate has been developed.

Rationale: Uterine carcinosarcoma (UCS) is a rare and highly invasive malignant tumor.It exhibits an ectopic growth pattern of the uterus,and its histological features are biphasic differentiation epithelial components (cancer) mesenchymal (sarcoma). The pathological high-component neuroendocrine extremely rare. Due to inherent heterogeneity tumors, it increases difficulty accurate identification diagnosis. author introduces case primary endometrial (heterologous) with small cell carcinoma...

A one-pot reaction was developed to synthesise a variety of 1-iodoindolizines from substituted acetophenone, acetic acid, pyridine, and molecular iodine. The structure 3-benzoyl-1-iodoindolizine (2a) 1,3-dibenzoylindolizine (3a) further confirmed by X-ray single crystal analysis.

An efficient and straightforward multicomponent synthetic protocol has been developed for the preparation of three kinds highly functionalised piperidines via reaction between aromatic aldehydes, ammonium acetate, cyanoacetates and/or nitromethane generation a wide range structurally interesting pharmacologically significant compounds. The structure ethyl 3-cyano-2,4,6-tris(4-methoxyphenyl)-5-nitropiperidine-3-carboxylate, 3-cyano-2,4,6-tris(3-methoxyphenyl)-5-nitropiperidine-3-carboxylate...

An one-pot-reaction methodology was developed to synthesize a variety of polysubstituted 3-aryl-2-arylmethylene amino-4-hydroxybenzofurans from substituted β-nitrostyrenes, aromatic aldehydes, ammonium acetate, and cyclohexane-1,3-diones for the generation wide range structurally interesting pharmacologically significant compounds. The reaction pathway involves Michael addition nitrostyrenes cyclohexane-1,3-diones, then nucleophilic 2-(2-nitro-1-phenylethyl)cyclohexane-1,3-dione Schiff base...

ABSTRACT An effective and practical method has been developed for the diversity‐oriented synthesis of 1‐alkyl‐3‐aroylindolizines via 1,3‐dipolar cycloaddition pyridinium ylides aliphatic aldehydes in presence molecular iodine a catalytic amount MnO 2 . The proceeds by tandem reactions involving [3+2] cycloaddition, dehydration cycloadduct, dehydroaromatization. Molecular served both as catalyst dehydroaromatization reagent reaction.

An efficient and straightforward one-pot synthetic protocol has been developed for the synthesis of 3-arylindolizine-1-carboxylates via 1,3-dipolar annulation 2-(2-nitro-1-arylethyl)malonates with pyridine subsequent aromatisation in presence molecular iodine. The structure methyl 3-(4-methoxyphenyl)indolizine-1-carboxylate (2a) 3-iodo-2-(4-nitrophenyl)indolizine-1-carboxylate (2f) was further confirmed by X-ray single crystal analysis.

GRAPHICAL ABSTRACT

Fermentation of xylanase produced by Trichoderma reesei was conducted in 250mL shake flasks. Several fermentation conditions investigated that affected production Trichod erma , including inoculum age, size, medium volume, shear stress, temperature, shaking speed and initial pH. Results showed the optimum culture were as follows: age 45h, size 10%,medium volume 50mL/250mL, 200rpm pH4.0(natural). The maximum activity under each condition occurred at 104h maximal activities can reach 1425.27U/mL.

Abstract The ratios of the substrates as well amount base play a crucial role in outcome reaction.

Abstract A four‐component synthesis of functionalized 4‐hydroxybenzofurans is developed using nitrostyrenes, aromatic aldehydes, cyclohexane‐1,3‐diones and ammonium acetate as the reactants.

Abstract This reaction involves the sequential iron trichloride‐mediated nucleophilic addition followed by intramolecular transesterification and reaction.

Abstract The reaction does not allow the use 1,1‐dicyanocyclopropanes instead of 1‐cyanocyclopropane‐1‐carboxylates.