A5069375904- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Research on Leishmaniasis Studies
- Trace Elements in Health
- Mollusks and Parasites Studies
- MicroRNA in disease regulation
- Neuroendocrine regulation and behavior
- Helminth infection and control
- Military History and Strategy
- Animal Ecology and Behavior Studies
- Trypanosoma species research and implications
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Global Maternal and Child Health
- Iron Metabolism and Disorders
- Paleopathology and ancient diseases
Fudan University
2021-2025
State Key Laboratory of Genetic Engineering
2022-2025
Huashan Hospital
2022-2023
The evolution and adaptation of S. japonicum, a zoonotic parasite that causes human schistosomiasis, remain unclear because the lack whole-genome data. We construct chromosome-level japonicum genome analyze it together with 72 samples representing six populations entire endemic region. observe Taiwan zoophilic lineage splitting from ∼45,000 years ago, consistent divergent history their intermediate hosts. Interestingly, we detect severe population bottleneck in largely coinciding Asia during...
Schistosomes are flatworm parasites that undergo a complex life cycle involving two hosts. The regulation of the parasite’s developmental processes relies on both coding RNAs and non-coding RNAs. However, roles RNAs, including long (lncRNAs) in schistosomes remain largely unexplored. Here we conduct advanced RNA sequencing male female S . japonicum during their pairing reproductive development, resulting identification nearly 8,000 lncRNAs. This extensive dataset enables us to construct...
Schistosomiasis affects more than 250 million people worldwide and is one of the neglected tropical diseases. Currently, treatment schistosomiasis relies on a single drug-praziquantel-which has led to increasing pressure from drug resistance. Therefore, there an urgent need find new treatments. The development genome sequencing provided valuable information for understanding biology schistosomes. In Schistosoma japonicum , approximately 11% protein-coding sequences are uncharacterized genes...
Abstract Background Schistosomiasis is a disease primarily caused by eggs laid pathogens called schistosomes. Among the schistosome species infecting humans, Schistosoma japonicum possesses largest fecundity; each adult female produces an average of 3500 per day. The lack proper culture conditions supporting continuous oviposition in vitro has precluded detailed investigation mechanisms regulating sexual maturation and egg production . Methods We optimized replacing reagents that are part...
Eggs laid by mature female schistosomes are primarily responsible for the pathogenesis of schistosomiasis and critical transmission. Consequently, elucidating mechanism sexual maturation as well egg production may lead to new strategies control schistosomiasis. MicroRNAs (miRNAs) involved in multiple biological processes including reproduction many organisms, yet their roles have not been characterized schistosomes. Here, we investigated microRNA-1 (miR-1), which was downregulated gradually...
Schistosoma japonicum is prevalent in Asia with a wide mammalian host range, which leads to highly harmful zoonotic parasitic diseases. Most previous transcriptomic studies have been performed on this parasite, but mainly focus stages inside the host. Moreover, few larval data are available public databases. Here we mapped detailed transcriptome profiles of four S. including eggs, miracidia, sporocysts and cercariae, providing comprehensive development picture outside By analyzing...
Schistosomiasis, an acute and chronic parasitic disease, causes substantial morbidity mortality in tropical subtropical regions of the world. Iron is essential constituent numerous macromolecules involving important cellular reactions virtually all organisms. Trematodes genus Schistosoma live iron-rich blood, feed on red blood cells store abundant iron vitelline cells. Ferritins are multi-meric proteins that inside Three ferritin isoforms japonicum known, namely SjFer0, SjFer1 SjFer2;...
Schistosomiasis is a zoonotic parasitic disease caused by schistosome infection that severely threatens human health. Therapy relies mainly on single drug treatment with praziquantel. Therefore, there an urgent need to develop alternative medicines. The glutamate neurotransmitter in helminths involved many physiological functions interacting various cell-surface receptors. However, the roles and detailed regulatory mechanisms of metabotropic receptor (mGluR) growth development Schistosoma...
Abstract Pomacea canaliculata, an invasive species native to South America, is recognized for its broad geographic distribution and adaptability a variety of ecological conditions. The details concerning the evolution adaptation P. canaliculate remain unclear due lack whole-genome resequencing data. We examined 173 canaliculata genomes representing 17 populations in East Southeast Asia. Interestingly, showed higher level genetic diversity than other mollusks, our analysis suggested that...
Background: Hundreds of miRNAs have been identified in the human parasite schistosomes, while only a handful them are characterized functionally.Methods: The expression level microRNA-1 (miR-1) Schistosoma japonicum was examined by qRT-PCR. effect miR-1 on parasites evaluated vitro overexpression with miRNA agomir. target genes were predicted through silico analysis and validated dual-luciferase reporter gene assays. localization these detected using situ hybridization, their roles at...