A5101982962- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Pesticide Exposure and Toxicity
- Helminth infection and control
- Trace Elements in Health
- Toxic Organic Pollutants Impact
- Vector-borne infectious diseases
- Malaria Research and Control
- Research on Leishmaniasis Studies
- Environmental Toxicology and Ecotoxicology
- Insect and Pesticide Research
- Viral gastroenteritis research and epidemiology
- Mosquito-borne diseases and control
- Pesticide Residue Analysis and Safety
- Parasitic Infections and Diagnostics
- Genetics and Neurodevelopmental Disorders
- Carcinogens and Genotoxicity Assessment
- Toxin Mechanisms and Immunotoxins
- Microbial infections and disease research
- Viral Infections and Vectors
- Cholinesterase and Neurodegenerative Diseases
- interferon and immune responses
- Microbial Fuel Cells and Bioremediation
- Transgenic Plants and Applications
- Circadian rhythm and melatonin
National Institute for Parasitic Diseases
2012-2025
Academy of Military Medical Sciences
2014-2023
National Health and Family Planning Commission
2020-2022
World Health Organization - Pakistan
2022
Ministry of Public Security of the People's Republic of China
2021
Hospital for Tropical Diseases
2018
National Science and Technology Council
2018
Columbia University Irving Medical Center
2016
National Center of Biomedical Analysis
2016
Shanghai Normal University
2014-2016
Abstract Eggs produced by the mature female parasite are responsible for pathogenesis and transmission of schistosomiasis. Female schistosomes rely on a unique male-induced strategy to accomplish reproductive development, process that is incompletely understood. Here we map detailed transcriptomic profiles male Schistosoma japonicum across eight time points throughout sexual developmental from pairing maturation. The dynamic gene expression pattern data reveal clear sex-related...
Background Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which significant cause of morbidity in China and the Philippines. A single draft genome was available for S. japonicum, yet this assembly very fragmented only covers 90% genome, make it difficult to be applied as reference functional analysis genes discovery. Findings In study, we present high-quality fluke by combining 20 G (~53X) long molecule real time sequencing reads with 80 (~ 213X) Illumina...
We have previously reported linkage of markers on chromosome 1q22 to schizophrenia, a finding supported by several independent studies. Within this region, we identified significant disequilibrium between schizophrenia and within the gene for carboxyl-terminal PDZ ligand neuronal nitric oxide synthase (CAPON). Prior sequencing ten exons CAPON failed reveal coding mutation associated with illness.We screened human fetal brain cDNA library new isoform that consists terminal two gene, verified...
The evolution and adaptation of S. japonicum, a zoonotic parasite that causes human schistosomiasis, remain unclear because the lack whole-genome data. We construct chromosome-level japonicum genome analyze it together with 72 samples representing six populations entire endemic region. observe Taiwan zoophilic lineage splitting from ∼45,000 years ago, consistent divergent history their intermediate hosts. Interestingly, we detect severe population bottleneck in largely coinciding Asia during...
Despite of numerous studies on periodontitis, the mechanism underlying progression periodontitis still remains largely unknown. This study aimed to have an expression profiling comparison between and normal control identify more candidate genes involved in gain insights into molecular mechanisms progression. The gene profile GSE16134, comprising 241 gingival tissue specimens 69 healthy samples as which were obtained from 120 systemically patients with (65 chronic 55 aggressive...
Glycosaminoglycan (GAG) molecules on the surface of red blood cells play an important regulatory role in invasion merozoites apicomplexan protozoa. Heparan sulfate, a type GAG molecule, has been identified as receptor facilitating by these parasites. Proteins parasite that exhibit strong affinity for heparin may pivotal this process. This study aims to use proteomics identify Babesia microti proteins with high binding heparin. Bioinformatics was utilized analyze subcellular localization and...
Nerve agents (NAs) are notorious chemical warfare that pose a serious threat to national security and public health. The total number of theoretical chemicals NAs their degradation products (DPs) exceeds 410 000, according 1.A.01–1.A.03 in the Schedules Chemicals Chemical Weapons Convention, which poses great challenges for identification verification. A three-step integrated untargeted screening strategy was developed based on high-resolution mass spectrometry. First, an extensible homemade...
Decontamination is one of the most effective ways to reduce hazards different sulfur mustards. Herein, reactions various mustards with four classic decontaminant agents were investigated and their products identified by UPLC-MS/HRMS GC-MS. Quantitative determinations individual in reaction mixture allows evaluate kinetic parameters mustard reactions. The degradation rate 1,2-bis(2-chloroethylthio) ethane bis(2-chloroethylthioethyl) ether obviously faster than that (SM), but...
Schistosomiasis japonica is a zoonosis with number of mammalian species acting as reservoir hosts, including water buffaloes which can contribute up to 75% human transmission in the People's Republic China. Determining prevalence and intensity Schistosoma japonicum hosts important for calculating rates determining environmental contamination. A new procedure, formalin–ethyl acetate sedimentation-digestion (FEA–SD) technique, increased visualization S. eggs bovine feces, described that an...
Abstract A key issue when researching land degradation is the pollution of soils. For bioremediation contaminated soil, Burkholderia sp. XTB‐5 cells were obtained from soil and grown on mineral salt medium with initial phenol concentrations 650 mg L −1 850 , which found to degrade more than 98% content in less 4 days. About 90% (with concentration 250 kg soil) was removed inoculated 6 More within 20 days after co‐introduction plants sterilized a greenhouse or natural field trials. But under...
Sulfur mustard (SM) is a powerful alkylating vesicant that can rapidly penetrate skin, ocular, and lung bronchus mucous membranes react with numerous nucleophiles in vivo. Although the lesion mechanisms of SM remain unclear, DNA damage believed to be most crucial factor initiating SM-induced toxicity. Four major adducts were identified for retrospective detection evaluation, namely, N7-[2-[(2-hydroxyethyl)thio]-ethyl]guanine (N7-HETEG), bis(2-ethyl-N7-guanine)thioether (Bis-G),...
T-2 toxin poses a great threat to human health because it has the highest toxicity of currently known trichothecene mycotoxins. To understand in vivo and transformation mechanism toxin, we investigated role one kind principal phase I drug-metabolizing enzymes (cytochrome P450 [CYP450] enzymes) on metabolism which are crucial endogenous substances xenobiotics. We also carboxylesterase, plays an important toxic substances.
Schistosoma japonicum is a significant public health risk in parts of China and elsewhere Southeast Asia. To gain an insight into the epidemiology schistosomiasis japonica, detailed investigation S. genetic population structure needed. Using three mitochondrial DNA fragments ten microsatellite loci, we investigated diversity within among twelve populations sampled on geographical scale covering most major endemic areas. lineages from Indonesia, Philippines Chinese Taiwan were clearly...
China has made progress in malaria control and aims to eliminate nationwide, but implementing effective interventions along the border regions remain a huge task. The Plasmodium falciparum cases imported from Southeast Asia frequently reported especially China-Myanmar (CMB) area. Though, information is scant on P. genetic variability this This study isolates genome sequence of six clinical CMB Furthermore, we estimated nucleotide diversity, Watterson's estimator Tajima's D value for whole...
Schistosomiasis is a disease caused by parasitic worms and more than 200 million people are infected worldwide. The emergence of resistance to the most commonly used drug, praziquantel (PZQ), makes development novel drugs an urgent task. 3-oxoacyl-ACP reductase (OAR), key enzyme involved in fatty acid synthesis pathway, has been identified as potential drug target against many pathogenic organisms. However, no research on Schistosoma japonicum OAR (SjOAR) reported. characterization SjOAR...
The reproductive development and maturation of female schistosomes are crucial since their released eggs responsible for the host immunopathology transmission schistosomiasis. However, little is known about nutrients required by Schistosoma japonicum during its sexual maturation. We evaluated promoting effect several (calf serum, red blood cells (RBCs), ATP hypoxanthine) on pre-adult females at 18 days post infection (dpi) from mixed infections 50 dpi unisexual laboratory mice in basic...
Schistosoma japonicum is prevalent in Asia with a wide mammalian host range, which leads to highly harmful zoonotic parasitic diseases. Most previous transcriptomic studies have been performed on this parasite, but mainly focus stages inside the host. Moreover, few larval data are available public databases. Here we mapped detailed transcriptome profiles of four S. including eggs, miracidia, sporocysts and cercariae, providing comprehensive development picture outside By analyzing...
The blood fluke, Schistosoma japonicum still causes severe disease in China, the Philippines and Indonesia. Although there have been some studies molecular epidemiology of this persistent harmful parasite, few explored possibility implications selection S. populations. We analyzed diversity looked for evidence at three nuclear genes (SjIpp2, SjFabp SjT22.6) 13 SjT22.6 was found to exhibit high nucleotide under positive mountainous region mainland China. As a tegumental protein, its secondary...