A5073984054- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Helminth infection and control
- Global Maternal and Child Health
- Child Nutrition and Water Access
- Parasitic Infections and Diagnostics
- Zoonotic diseases and public health
- Parasitic Diseases Research and Treatment
- Parasitic infections in humans and animals
- Islamic Finance and Communication
- Religion, Spirituality, and Psychology
- Ubiquitin and proteasome pathways
- Media, Religion, Digital Communication
- CRISPR and Genetic Engineering
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Neuroendocrine regulation and behavior
- COVID-19 and Mental Health
- Microtubule and mitosis dynamics
- Wnt/β-catenin signaling in development and cancer
- Dermatological diseases and infestations
- Viral gastroenteritis research and epidemiology
- Research on Leishmaniasis Studies
QIMR Berghofer Medical Research Institute
2016-2025
The University of Queensland
2011-2025
Stanford University
2013-2023
University of California, Davis
2010-2013
Centers for Disease Control and Prevention
2011
University of London
1946
Memorial
1946
Adelphi Group (United Kingdom)
1946
The escalating problem of multiple chronic conditions (MCC) among Americans is now a major public health and medical challenge, associated with suboptimal outcomes rising health-care expenses. Despite this problem's growth, the delivery services has continued to employ outmoded "siloed" approaches that focus on individual diseases. We describe an action-oriented framework--developed by U.S. Department Health Human Services additional input provided stakeholder organizations--that outlines...
The DNTM3A and DNMT3B de novo DNA methyltransferases (DNMTs) are responsible for setting genomic methylation patterns, a key layer of epigenetic information. Here, using an in vivo episomal assay extensive bisulfite sequencing, we show that human DNMT3A possess significant distinct flanking sequence preferences target CpG sites. Selection high or low efficiency sites is mediated by the base composition at −2 +2 positions site DNMT3A, −1 +1 DNMT3B. This intrinsic preference reproducibly leads...
There is currently considerable international debate around school closures/openings and the role of children in transmission coronavirus disease 2019 (COVID-19). Whilst evidence suggests that are not impacted by COVID-19 as severely adults, little still known about their potential, with a lot asymptomatic cases they may be silent transmitters (i.e. infectious without showing clinical signs disease), albeit at lower level than adults. In relation to this, it somewhat concerning many...
Schistosomiasis is a disease that significantly impacts human health in the developing world. Effective diagnostics are urgently needed for improved control of this disease. CRISPR-based technology has rapidly accelerated development revolutionary and powerful platform, resulting advancement class ultrasensitive, specific, cost-effective portable diagnostics, typified by applications COVID-19/cancer diagnosis.
Schistosoma japonicum is endemic in the Philippines, China and Indonesia, infects more than 40 mammalian host species, all of which can act as reservoirs infection. In China, water buffaloes have been shown to be major human However, carabao not considered important reservoir hosts for S. due low prevalence infection intensities reported, only exception being a qPCR-based study indicating 51% were japonicum-positive. found same animals when using conventional copro-parasitological techniques...
Background The Philippines has a population of approximately 103 million people, which 6.7 live in schistosomiasis-endemic areas with 1.8 people being at risk infection Schistosoma japonicum. Although the country-wide prevalence schistosomiasis japonica is relatively low, can be high, approaching 65% some endemic areas. Of currently available microscopy-based diagnostic techniques for detecting schistosome infections and elsewhere, most exhibit varying performances, Kato-Katz (KK) method...
We have previously identified nucleolar and spindle associated protein 1 (NUSAP1) as a prognostic biomarker in early stage prostate cancer. To better understand the role of NUSAP1 cancer progression, we tested effects increased decreased expression cell lines, vivo models, patient samples. promotes invasion, migration, metastasis, possibly by modulating family with sequence similarity 101 member B (FAM101B), transforming growth factor beta (TGFβ1) signaling effector involved epithelial to...
Schistosomiasis japonica remains a major public health and socioeconomic concern in Southeast Asia. Sensitive accurate diagnostics can play pivotal role achieving disease elimination goals.We previously reported novel droplet digital polymerase chain reaction (ddPCR) assay targeting the mitochondrial gene nad1 to diagnose schistosomiasis japonica. The tool identified both prepatent patent infections using Schistosoma japonicum DNA isolated from serum, urine, salivary glands, feces murine...
SUMMARY Schistosomiasis in China has been substantially reduced due to an effective control programme employing various measures including bovine and human chemotherapy, the removal of bovines from endemic areas. To fulfil elimination targets, it will be necessary identify other possible reservoir hosts for Schistosoma japonicum include them future efforts. This study determined infection prevalence S. rodents (0–9·21%), dogs (0–18·37%) goats (6·9–46·4%) Dongting Lake area Hunan province,...
Inactive DNA methyltransferase (DNMT) 3B splice isoforms are associated with changes in methylation, yet the mechanisms by which they act remain largely unknown. Using biochemical and cell culture assays, we show here that inactive DNMT3B3 DNMT3B4 bind to regulate activity of catalytically competent DNMT3A or DNMT3B molecules. modestly stimulated de novo methylation also counteracted stimulatory effects DNMT3L, therefore leading subtle contrasting on activity. DNMT3B4, contrast,...
The cause of zoonotic schistosomiasis in the Philippines is Schistosoma japonicum, which infects up to 46 mammalian hosts, including humans and bovines. In China, water buffaloes have been identified as major reservoir hosts for japonica, contributing 75% human transmission. Philippines, (carabao; Bubalus bubalis carabanesis) have, historically, considered unimportant reservoirs. We therefore revisited possible role bovines schistosome transmission using recently described formalin-ethyl...
Background Soil-transmitted helminths (STH) are the most common parasitic infections in impoverished communities, particularly among children. Current STH control is through school-based mass drug administration (MDA), which Philippines done twice annually. As expected, MDA has decreased intensity and prevalence of over time. a result, Kato Katz (KK) thick smear method detecting less effective because it lacks sensitivity low infections, making difficult to measure impact deworming programs....
Schistosomiasis in the People's Republic of China (PRC) can be traced back to antiquity. In past 60 years, Chinese government has made great efforts control this persistent disease with elimination slated by 2020 through implementation a comprehensive strategy. This strategy aims reduce role bovines and humans as sources infection pre-requisite for transmission interruption. The goal will achievable only sustainable surveillance system, sensitive diagnosis key feature so that true burden is...