A5062696585- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Global Maternal and Child Health
- Child Nutrition and Water Access
- Helminth infection and control
- Parasitic Infections and Diagnostics
- Malaria Research and Control
- Mosquito-borne diseases and control
- Global Health and Surgery
- Misinformation and Its Impacts
- Vaccine Coverage and Hesitancy
- Biosensors and Analytical Detection
- Digital Imaging for Blood Diseases
- Viral Infections and Vectors
- Data Stream Mining Techniques
- COVID-19 epidemiological studies
- Congenital Anomalies and Fetal Surgery
- Insects and Parasite Interactions
- Colorectal Cancer Screening and Detection
- Coccidia and coccidiosis research
- Parasitic infections in humans and animals
- Gut microbiota and health
- COVID-19 and Mental Health
- Trace Elements in Health
- Blockchain Technology Applications and Security
Ministry of Health
2016-2025
Nkumba University
2025
Uganda Management Institute
2018-2022
Virtual University of Uganda
2022
Makerere University
2013-2014
Ministry of Health
2009
Rapid, low-cost, species-specific diagnosis, based upon DNA testing, is becoming important in the treatment of patients with infectious diseases. Here, we demonstrate an innovation that uses origami to enable multiplexed, sensitive assays rival polymerase chain reactions (PCR) laboratory and provide high-quality, fast precision diagnostics for malaria. The paper-based microfluidic technology proposed here combines vertical flow sample-processing steps, including paper folding whole-blood...
Schistosomiasis is a disease that significantly impacts human health in the developing world. Effective diagnostics are urgently needed for improved control of this disease. CRISPR-based technology has rapidly accelerated development revolutionary and powerful platform, resulting advancement class ultrasensitive, specific, cost-effective portable diagnostics, typified by applications COVID-19/cancer diagnosis.
For disease surveillance and mapping within large-scale control programmes, RDTs are becoming popular. intestinal schistosomiasis, a commercially available urine-dipstick which detects schistosome circulating cathodic antigen (CCA) in host urine is being increasingly applied, however, further validation needed. In this study, we compared the CCA test against double thick Kato-Katz faecal smears from 171 schoolchildren examined along Tanzanian Kenyan shorelines of Lake Victoria. Diagnostic...
Background In Uganda, control of intestinal schistosomiasis with preventive chemotherapy is typically focused towards treatment school-aged children; the needs younger children are presently being investigated as in lakeshore communities very young can be infected. context future epidemiological monitoring, we sought to compare detection thresholds available diagnostic tools for Schistosoma mansoni and estimate a likely age first infection these children. Methods Findings A total 242 infants...
Control and elimination of the parasitic disease schistosomiasis relies on mass administration praziquantel. Whilst these programmes reduce infection prevalence intensity, their impact parasite transmission evolution is poorly understood. Here we examine genomic repeated drug Schistosoma mansoni populations with documented reduced praziquantel efficacy. We sequenced whole-genomes 198 S. larvae from 34 Ugandan children regions contrasting exposure. Parasites infecting Lake Victoria, a...
SUMMARY During a longitudinal study investigating the dynamics of malaria in Ugandan lakeshore communities, consistently high prevalence was observed young children despite regular treatment. To explore short-term performance artemether-lumefantrine (AL), pilot investigation into parasite carriage after treatment(s) conducted Bukoba village. A total 163 (aged 2–7 years) with positive blood film and rapid antigen test were treated AL; only 8·7% these had elevated axillary temperatures. On day...
The World Health Organization (WHO) recommends praziquantel mass drug administration (MDA) to control schistosomiasis in endemic regions. We aimed quantify recent and lifetime coverage, reasons for non-treatment, at an individual level guide policy recommendations help Uganda reach WHO goals. Cross-sectional household surveys (n = 681) encompassing 3208 individuals (adults children) were conducted 2017 Bugoto A B, Mayuge District, Uganda. Participants asked if they had received during the...
Background Calprotectin is a calcium-binding cytoplasmic protein found in neutrophils and increasingly used as marker of bowel inflammation. Fecal occult blood (FOB) also dependable indicator morbidity. The objective our study was to determine the applicability these tests surrogate markers Schistosoma mansoni intestinal morbidity before after treatment with praziquantel (PZQ). Methods 216 children (ages 3–9 years old) from Buliisa District Lake Albert, Uganda were examined treated PZQ at...
<ns4:p>Controlled human infection (CHI) models are gaining recognition as an approach to accelerating vaccine development, for use in both non-endemic and endemic populations: they can facilitate identification of the most promising candidate vaccines further trials advance understanding protective immunity. Helminths present a continuing health burden sub-Saharan Africa. Vaccine development these complex organisms is particularly challenging, partly because responses akin mechanisms...
Schistosomiasis is a major socio-economic and public health problem in many sub-Saharan African countries. After large mass drug administration (MDA) campaigns, prevalence of infection rapidly returns to pre-treatment levels. The traditional egg-based diagnostic for schistosome infections, Kato-Katz, being substituted settings by circulating antigen recognition-based diagnostics, usually the point-of-care cathodic test (CCA). relationship between these diagnostics poorly understood,...
Even with a national control programme in place, intestinal schistosomiasis continues to be major public health problem school-aged children and other community members Uganda. This is especially the case environments around Great Lakes, where disease transmission high, such as Lake Victoria. Moreover, most remote areas, some schools might periodically miss large-scale drug administrations owing inaccessibility. To provide contemporary monitoring surveillance data, 27 along lakeshore were...
Abstract Background Intestinal schistosomiasis is often widespread among the populations living around Lake Victoria and on its islands. The Sesse Island group (containing some 84 islands), however, typically assumed to be a low prevalence zone, with limited transmission, but has never been surveyed in detail. Here, we present rapid mapping assessment, bringing together snail parasite information, at 23 sites for presence of intermediate host snails 61 intestinal school-aged children (N =...
Background Namibia is now ready to begin mass drug administration of praziquantel and albendazole against schistosomiasis soil-transmitted helminths, respectively. Although historical data identifies areas transmission these neglected tropical diseases (NTDs), there a need update epidemiological data. For this reason, adopted new protocol for mapping geohelminths, formally integrating rapid diagnostic tests (RDTs) infections morbidity. In article, we explain the in detail, introduce concept...
Intestinal schistosomiasis is of public health importance in Uganda but communities living above 1400 m are not targeted for control as natural transmission thought unlikely. To assess altitudinal boundaries and at-risk populations, conjoint malacological epidemiological surveys were undertaken on Mount Elgon (1139 m–3937 m), Fort Portal crater lakes the Rwenzori Mountains (1123 m–4050 m). Seventy freshwater habitats [Mount (37), (23), (8) Lake Albert (2)] inspected Biomphalaria species....
<ns4:p>Controlled human infection (CHI) models are gaining recognition as an approach to accelerating vaccine development, for use in both non-endemic and endemic populations: they can facilitate identification of the most promising candidate vaccines further trials advance understanding protective immunity. Helminths present a continuing health burden sub-Saharan Africa. Vaccine development these complex organisms is particularly challenging, partly because responses akin mechanisms...
Abstract Programmatic surveillance of intestinal schistosomiasis during control can typically use four diagnostic tests, either singularly or in combination, but these have yet to be cross-compared directly. Our study assembled a complete dataset, inclusive infection intensities, from 258 children five Ugandan primary schools. The schools were purposely selected as typical the endemic landscape near Lake Albert and reflective high- low-transmission settings. Overall prevalence was: 44.1%...
Background Soil-transmitted Helminths and Anemia potentially reduce retard cognitive physical growth in school-age children with great implications for national control programs Africa. After 13 years of deworming limited health education campaigns, a study was undertaken to evaluate the impact interventions on prevalence intensity soil-transmitted helminthic infections Uganda. Methodology A cross-sectional carried out six regions Uganda, where two districts were randomly selected per region...
Abstract Background A key component of schistosomiasis control is mass drug administration with praziquantel. While interventions have been successful in several endemic regions, has less effective others. Here we focus on the impact repeated praziquantel treatment population structure and genetic diversity Schistosoma mansoni . Methods We examined S. epidemiology, genetics, variation susceptibility parasites isolated from children across three primary schools a high endemicity region at...
Background Knowing the prevalence of schistosomiasis is key to informing programmes control and eliminate disease as a public health problem. It also important understand impact infection on child growth development in order allocate appropriate resources effort disease. Methods We conducted survey estimate among school aged children villages along Albert-Nile shore line district Pakwach, North Western Uganda. A total 914 between 10–15 years were screened for Schistosoma mansoni using...