A5081549007- Catalytic C–H Functionalization Methods
- Peroxisome Proliferator-Activated Receptors
- Synthesis and Biological Evaluation
- Chemical synthesis and alkaloids
- Cholinesterase and Neurodegenerative Diseases
- Sulfur-Based Synthesis Techniques
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- CRISPR and Genetic Engineering
- Phosphodiesterase function and regulation
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Eicosanoids and Hypertension Pharmacology
- Oxidative Organic Chemistry Reactions
- Alkaloids: synthesis and pharmacology
- Cholesterol and Lipid Metabolism
- Synthesis and biological activity
- Catalytic Alkyne Reactions
- Management of metastatic bone disease
- Advanced biosensing and bioanalysis techniques
- Photochromic and Fluorescence Chemistry
University of Southern California
2023-2024
Lundbeck (United States)
2010-2012
Princeton University
2005-2010
Pfizer (United States)
2009-2010
NOAA Chemical Sciences Laboratory
2010
GlaxoSmithKline (United States)
2001-2002
Research Triangle Park Foundation
2001-2002
Abstract Among the potential therapeutic targets for development of cognitive enhancers AD and schizophrenia, 5‐HT 6 receptor is especial interest based on its localization, pharmacology, recent behavioral data showing that blockade improves cognition in a number rodent models. It localized almost exclusively CNS, areas important learning memory, while atypical antipsychotics tricyclic antidepressants bind with high affinity to this target. antagonism enhances neurotransmission at...
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTRearrangement of 3,3-Disubstituted Indolenines and Synthesis 2,3-Substituted IndolesKevin G. Liu, Albert J. Robichaud, Jennifer R. Lo, James F. Mattes, Yanxuan CaiView Author Information Chemical & Screening Sciences, Wyeth Research, CN 8000, Princeton, New Jersey 08543 Cite this: Org. Lett. 2006, 8, 25, 5769–5771Publication Date (Web):November 15, 2006Publication History Received25 September 2006Published online15 November inissue 1 December...
As part of our efforts to develop agents for CNS diseases, we have been focused on the 5-HT(6) receptor in order identify potent and selective ligands cognitive enhancement. Herein report identification a novel series 5-piperazinyl-3-sulfonylindazoles as antagonists. The synthesis, SAR, pharmacokinetic pharmacological activities some compounds including 3-(naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1H-indazole (WAY-255315 or SAM-315) will be described.
CRISPR-associated proteins such as Cas9 and Cas12a are programable RNA-guided nucleases that have emerged powerful tools for genome manipulation molecular diagnostics. However, these enzymes prone to cleaving off-target sequences contain mismatches between the RNA guide DNA protospacer. In comparison Cas9, has demonstrated distinct sensitivity protospacer-adjacent-motif (PAM) distal mismatches, basis of Cas12a's enhanced target discrimination is great interest. this study, we investigated...
There is an increasing amount of evidence to support that activation the metabotropic glutamate receptor 4 (mGlu4 receptor), either with orthosteric agonist or a positive allosteric modulator (PAM), provides impactful interventions in diseases such as Parkinson's disease, anxiety, and pain. mGlu4 PAMs may have several advantages over agonists for number reasons. As part our efforts identifying therapeutics central nervous system (CNS) we been focusing on receptors. Herein report studies...
CRISPR-associated proteins such as Cas9 and Cas12a are programable RNA-guided nucleases that have emerged powerful tools for genome manipulation molecular diagnostics. However, these enzymes prone to cleaving off-target sequences contain mismatches between the RNA guide DNA protospacer. In comparison Cas9, has demonstrated distinct sensitivity protospacer-adjacent-motif (PAM) distal mismatches, basis of Cas12a's enhanced target discrimination is great interest. this study, we investigated...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access Abstract, please click on HTML or PDF.