A5028863507- Testicular diseases and treatments
- Urologic and reproductive health conditions
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Sarcoma Diagnosis and Treatment
- Social Sciences and Governance
- Sexual Differentiation and Disorders
- Genital Health and Disease
- Renal and related cancers
- Renal and Vascular Pathologies
- Ureteral procedures and complications
- Urinary and Genital Oncology Studies
- Abdominal Trauma and Injuries
- Pelvic and Acetabular Injuries
- Accounting and Organizational Management
- Agriculture and Rural Development Research
- Colorectal and Anal Carcinomas
- Hernia repair and management
- Kidney Stones and Urolithiasis Treatments
- Ovarian cancer diagnosis and treatment
- Adrenal and Paraganglionic Tumors
- Cancer, Lipids, and Metabolism
Hôpital Paris Saint-Joseph
2020-2025
Hôpital Saint Joseph
2022-2025
MemorialCare Health System
2025
École Polytechnique
2024
Université de Rouen Normandie
2022
Hôpital d'Instruction des Armées Bégin
2016-2021
École nationale des ponts et chaussées
2021
HIA du Val-de-Grâce à Paris
2010-2020
Lymphoma Study Association
2016-2019
Sorbonne Université
2008-2018
Adoption of high-content omic technologies in clinical studies, coupled with computational methods, has yielded an abundance candidate biomarkers. However, translating such findings into bona fide biomarkers remains challenging. To facilitate this process, we introduce Stabl, a general machine learning method that identifies sparse, reliable set by integrating noise injection and data-driven signal-to-noise threshold multivariable predictive modeling. Evaluation Stabl on synthetic datasets...
The composition of a French Forward Surgical Team (FST) has remained constant since its creation in the early 1950s: 12 personnel, including general and an orthopaedic surgeon. training military surgeons, however, had to evolve adapt growing complexities modern warfare injuries context increasing subspecialisation within surgery. Advanced Course for Deployment Surgery (ACDS)-called Cours Avancé de Chirurgie en Mission Extérieure (CACHIRMEX)-has been designed extend, reinforce surgical skill...
Study Type – Diagnostic (exploratory cohort) Level of Evidence 2b What's known on the subject? and What does study add? PCA3 scores correlate to numerous histoprognostic factors, specifically tumour volume positive surgical margins. These results may have a clinical impact in near future selection patients eligible undergo active surveillance nerve‐sparing surgery. OBJECTIVE To assess correlations between Prostate CAncer gene 3 (PCA3) levels pathological features radical prostatectomy (RP)...
The lack of accuracy from typical prostate cancer diagnostic tools led us to investigate new biomarkers. Prostate gene 3 (PCA3 or DD3) is a promising urinary biomarker cancer. This specific noncoding mRNA highly overexpressed in more than 95% primary tumors. feasibility PCA3 gene-based molecular assay based on the detection cells urine has been demonstrated, and quantitative test with potential for general use clinical settings was developed; Progensa™ (Gen-Probe Inc., San Diego, CA, USA)...
• To investigate the relationship between pretreatment testosterone levels and pathological specimen characteristics, by prospectively examining serum androgen concentrations in a well-studied cohort of patients who underwent radical prostatectomy (RP) for localized prostate cancer.• A total 107 with clinically cancer had an assay before laparoscopic RP at our institution. The results were classified into two groups based on testosterone: group1, < 3 ng/mL; group 2, ≥ ng/mL. Student's t-test...
<title>Abstract</title> Postoperative pancreatic fistula (POPF) is the major driver of postoperative morbidity after pancreatoduodenectomy (PD). However, current preoperative prediction models lack precision. This study aimed to determine ability a high dimensional analysis from patient’s peripheral immune system before PD using mass cytometry and sparse machine learning (ML), predict POPF. Twenty-two patients in prospective IMMUNOPANC trial (NCT03978702) underwent PD. Blood samples...
Renal cell carcinomas (RCC) are increasing worldwide and obesity is one of its recognized causal factor. Obesity thus could be differently associated with the different histologic types renal tumors also impact prognosis patient care. primary objective was to evaluate an association between histological type RCC. The secondary assess if there effect on tumor characteristics. a multicenter comparative descriptive study carried out in nearly 30 french hospitals. Histological features operated...
Abstract Immune checkpoint inhibitors (ICIs) are currently the most effective treatment for late-stage lung cancer. However, patients fail to mount a durable response, and mechanisms underlying non-responsiveness remain elusive. Here, we apply universal omics approach identify correlates of ICIs in In-depth characterization plasma proteome was performed using SomaScan™ platform on pretreatment longitudinal blood samples from 40 ICI-treated patients, resulting quantification 10, 000 unique...
Context: With the increasing use of spectral flow and mass cytometry technologies, efficient single-cell phenotyping has become essential for identification complex cell populations. Traditionally, these populations are identified through manual gating, a time-consuming process that is also subject to variability lack reproducibility. Here, we adapted deep learning model [1] devise an automated gating pipeline with goal enhancing accuracy, speed, reproducibility immune gating. Methods: Our...
What's known on the subject? and What does study add? Positive surgical margin ( PSM ) frequency after radical cystectomy has been estimated to be 4–15%. Studies that have not distinguished between different sites of failed show they are an independent prognostic factor for disease‐free survival. Only perivesical soft tissue PSMs associated with increased risk cancer recurrence cancer‐specific death. This is first comprehensive published analysis occurring during pTx pN0 M0 bladder according...
Study Type – Diagnostic (case series) Level of Evidence 4 OBJECTIVE To investigate the role magnetic resonance imaging (MRI) in selecting patients for active surveillance (AS). PATIENTS AND METHODS We identified prostate cancers who had undergone a 21‐core biopsy scheme and fulfilled criteria as follows: prostate‐specific antigen (PSA) level ≤10 ng/mL, T1–T2a disease, Gleason score ≤6, <3 positive cores tumour length per core mm. included 96 underwent radical prostatectomy (RP) MRI before...
To review long-term oncological and functional outcomes of testicular-sparing surgery (TSS) in men presenting with bilateral or monorchide testicular tumours at one five reference centres for neoplasm infertility.We 25 cases synchrone metachrone treated academic between 1984 2013. Clinical, biological, ultrasonography pathological tumour findings, overall survival (OS) times, local metastatic recurrence, pre- postoperative hormonal profile, paternity the need androgen substitution were...
To evaluate the pathological features and recurrence of incidental testis tumours treated by partial orchiectomy in a population infertile men.We retrospectively pooled, from four andrology referral centres, 32 patients diagnosed with mass during regular infertility workup. Patients included had an impaired sperm analysis sparing surgery was performed to prevent secondary azoospermia or androgen therapy.Mean age 36 (IQR, 37). The mean largest tumoral diameter 8.5 mm 5 10). A total 25% (8 32)...
Objectives To assess the impact of pathological upstaging from clinically localized to locally advanced pT3a on survival in patients with renal cell carcinoma (RCC), as well oncological safety various surgical approaches this setting, and develop a machine‐learning‐based, contemporary, relevant model for individual preoperative prediction upstaging. Materials Methods Clinical data treated either partial nephrectomy (PN) or radical (RN) cT1/cT2a RCC 2000 2019, included French...