A5009606254- Reproductive System and Pregnancy
- Cytomegalovirus and herpesvirus research
- Advanced biosensing and bioanalysis techniques
- Medical and Biological Ozone Research
- Pregnancy and Medication Impact
- COVID-19 Impact on Reproduction
- Endometriosis Research and Treatment
- Long-Term Effects of COVID-19
- Herpesvirus Infections and Treatments
Noakhali Science and Technology University
2024
Bristol-Myers Squibb (United States)
2021-2022
Human cytomegalovirus (HCMV) is an important opportunistic pathogen that the most significant viral cause of congenital birth abnormalities and responsible for a high morbidity death rate in immunocompromised patients. HCMV's rising severity limitations current vaccines preventing infection highlight urgent need effective antiviral drugs. This study aimed to identify small compounds using extensive & appropriate in-silico drug design techniques, including molecular docking, Post-docking...
Abstract Background Ozanimod, an oral sphingosine 1-phosphate (S1P) receptor modulator selectively targeting S1P1 and S1P5, has demonstrated efficacy in patients with relapsing multiple sclerosis (rMS) ulcerative colitis (UC), is being studied Crohn’s disease (CD). S1P1-3 receptors are involved vascular formation during embryogenesis. Within studies the ozanimod clinical development program, female participants of childbearing potential were required to use effective contraception while...
Abstract Background Ozanimod, a sphingosine 1-phosphate (S1P) receptor S1P1 and S1P5 modulator, is approved in the United States for moderately to severely active ulcerative colitis (UC) multiple countries relapsing sclerosis (MS). We describe COVID-19 outcomes ozanimod-treated UC or MS patients (pts) phase 3 open-label extension (OLE) studies. Methods A database search identified infection reports pts with True North OLE DAYBREAK OLE. The analysis period was November 1, 2019 either August...