A5102900273- Fungal and yeast genetics research
- Microtubule and mitosis dynamics
- Hippo pathway signaling and YAP/TAZ
- Adipose Tissue and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- Plant Reproductive Biology
- Fermentation and Sensory Analysis
- Protein Kinase Regulation and GTPase Signaling
King's College London
2023
Communities In Schools of Orange County
2013
KRas has recently been shown to be activated by monoubiquitination (mUb). Similar oncogenic mutations, mUb of Ras at position 147 activates causing a defect in GTPase activating protein (GAP) function. To characterize the mechanism which impairs GAP-mediated downregulation Ras, we made various modifications and examined impact on sensitivity GAP Whereas small (iodoacetamide glutathione) do not affect hydrolysis, ligation UbG76C (native linker), UbX77C (one residue longer), PDZ2 (with native...
Polycyclic aromatic hydrocarbons (PAHs), in particular benzo [a]pyrene (BaP), have been identified as carcinogenic components of tobacco smoke. In mammals, the toxicological response to BaP-diol-epoxide is driven by cytochrome P450 (CYP1A1), a pathway which absent Caenorhabditis elegans. contrast, worms prominently CYP-35 enzyme family seems be induced after BaP exposure. C. elegans, exposure reduces accumulation lysosomal neutral lipids dose dependent manner and deletion cyp-35A2 results...