A5014766424- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cannabis and Cannabinoid Research
- Multiple Myeloma Research and Treatments
- Angiogenesis and VEGF in Cancer
- Protein Degradation and Inhibitors
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Hematological disorders and diagnostics
- Cytomegalovirus and herpesvirus research
- interferon and immune responses
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Neonatal Health and Biochemistry
- Neuroscience and Neuropharmacology Research
- Autophagy in Disease and Therapy
- Adenosine and Purinergic Signaling
- Cancer, Hypoxia, and Metabolism
University of Palermo
2023
University Hospital Bonn
2019-2022
University of Bonn
2020
Despite numerous studies conducted over the past decade, exact role of cannabinoid system in cancer development remains unclear. Though research has focused on two receptors (CB1, CB2) activated by most cannabinoids, CB2 holds greater attention due to its expression cells immune system. In particular, cytokine-induced killer (CIKs), which are pivotal cytotoxic immunological effector cells, express a high-level receptors. Herein, we sought investigate whether inducing CIK with cannabidiol can...
Multiple myeloma (MM) is characterized by aberrant bone marrow plasma cell (PC) proliferation and one of the most common hematological malignancies. The potential effect cannabinoids on immune system malignancies has been poorly characterized. Cannabidiol (CBD) may be used to treat various diseases. CBD known exert immunomodulatory effects through activation cannabinoid receptor 2 (CB2), which expressed in high levels hematopoietic system. Cytokine-induced killer (CIK) cells are a...
Ecto-5′-nucleotidase (CD73) catalyzes the hydrolysis of AMP to anti-inflammatory, immunosuppressive adenosine. It is expressed on vascular endothelial, epithelial, and also numerous cancer cells where it strongly contributes an microenvironment. In present study we designed synthesized fluorescent-labeled CD73 inhibitors with low nanomolar affinity high selectivity based N6-benzyl-α,β-methylene-ADP (PSB-12379) as a lead structure. Fluorescein was attached benzyl residue via different linkers...
Cytokine-induced killer (CIK) cells are ex vivo expanded major histocompatibility complex (MHC)-unrestricted cytotoxic with promising effects against a variety of cancer types. Regulatory T-cells (T-reg) have been shown to reduce the effectiveness CIK tumor cells. Peptide P60 has inhibit immunosuppressive functions T-regs. This study aimed at examining effect p60 on efficacy renal and pancreatic cells.The cytotoxicity was examined using flow cytometry, WST-8-based cell viability assay...
Summary Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), the first immune checkpoint to be targeted clinically, has provided an effective treatment option for various malignancies. However, clinical advantages associated with CTLA-4 inhibitors can offset by potentially severe immune-related adverse events (IRAEs), including autoimmune thyroid dysfunction. To investigate candidate genes and signaling pathways involving in dysfunction related anti-CTLA-4 therapy, integrated differentially...
Background/Aim: Cytokine-induced killer (CIK) cells are a heterogenous population of immune showing promising applications in immunotherapeutic cancer treatment. Neuropilin (NRP) proteins have been proven to play an important role development and prognosis. In this study, CIK were tested for expression NRPs, transmembrane playing the proliferation survival cells. Materials Methods: analyzed at different time points via flow cytometry quantitative real-time polymerase chain reaction...