A5009078168- COVID-19 Clinical Research Studies
- COVID-19 Impact on Reproduction
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Respiratory viral infections research
- Systemic Lupus Erythematosus Research
- Herpesvirus Infections and Treatments
- Trace Elements in Health
- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Pneumonia and Respiratory Infections
- Diagnosis and treatment of tuberculosis
- Pleural and Pulmonary Diseases
- Kawasaki Disease and Coronary Complications
- Sepsis Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Tuberculosis Research and Epidemiology
- Parvovirus B19 Infection Studies
Luigi Sacco Hospital
2020-2024
University of Milan
2020-2024
Background Data on the efficacy of three SARS-CoV-2 mRNA BNT162b2 vaccine doses and role previous SARS-CoV-2-infection in enhancing immunogenicity HIV-vertically-infected people living with HIV (PLWH) are limited, as is duration vaccine-induced responses. Methods plasma neutralizing activity (NA) against European (B.1), Delta (B.1.617.2) Omicron (B.1.1.529) variants cell-mediated immunity (CMI) were analyzed 29 ART-treated young PLWH (mean age 27.9 years) 30 healthy controls (HC) who...
While the risk of SARS-CoV-2 infection and/or COVID-19 disease progression in general population has been largely assessed, its impact on HIV-positive individuals remains unclear. We present clinical and immunological data collected a cohort HIV-infected young during first wave pandemic. RNA, virus-specific antibodies, as well expression factors involved anti-viral immune response were analyzed. Moreover, we set up an vitro coinfection assay to study mechanisms correlated process. Our...
Hepatitis C virus (HCV) infection natural history and management in the pediatric population are still debated. We retrospectively evaluated outcome of a HCV managed at Pediatric Infectious Disease Unit Luigi Sacco Hospital (Milan, Italy) from January 1997 to 2022 (median follow-up 10 years) we focused on role new drugs transient elastography. Fifty-seven patients were enrolled: 8 (14%) had spontaneous clearance, 33 treated (58%), 7 (12%) not because they under 12 years old 9 lost follow-up....
Congenital cytomegalovirus infection (cCMV) is the most common congenital viral infection, with a consistent rate of morbidity, mortality, and long-term sequelae, especially in case late diagnosis. Nevertheless, universal screening for CMV not currently recommended, global awareness about this as well accurate shared indications on follow-up treatment, are still lacking. We reviewed data 59 suspect cCMV cases who referred to our center from 2014 2021. report 41 confirmed diagnosed at birth,...
Abstract On January 7, 2020, a novel coronavirus (SARS‐CoV‐2) was identified as the causative agent of cluster pneumonia unknown origin detected in Wuhan City by Chinese authorities. Since SARS‐CoV‐2 discovery, corresponding disease (COVID‐19) has rapidly expanded throughout globe, making consequence World Health Organization (WHO) declaring pandemic. As May 19, over 4.806.299 cases COVID‐19 had been confirmed worldwide, with more than 318.599 deaths.
To the editor Necrotizing pneumonia (NP) is a complication of community-acquired that may affect healthy children.1 Particularly severe and rapidly evolving NP have been associated with Staphylococcus aureus strains producing Panton-Valentine Leukocidin (PVL), which pore forming exotoxin causes lysis leukocytes, leading to destruction surrounding tissue. Presentation during first months life very uncommon. Here we describe case caused by methicillin-resistant S. (MRSA) PVL in preterm baby. A...
The paper presents the case of Pakistani girl with low-grade fever, malaise and non-specific abdominal pain, finally diagnosed pulmonary extra-pulmonary TB.