A5082093753- Extracellular vesicles in disease
- Neural dynamics and brain function
- Advanced Nanomaterials in Catalysis
- Functional Brain Connectivity Studies
- Dental materials and restorations
- Electromagnetic wave absorption materials
- Immunotherapy and Immune Responses
- Advanced Antenna and Metasurface Technologies
- Virus-based gene therapy research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- EEG and Brain-Computer Interfaces
- Vehicular Ad Hoc Networks (VANETs)
- Endodontics and Root Canal Treatments
- Polymer composites and self-healing
- Ergonomics and Musculoskeletal Disorders
- Digital Communication and Language
- Privacy-Preserving Technologies in Data
- Neurobiology of Language and Bilingualism
- Advanced machining processes and optimization
- Tribology and Wear Analysis
- Metal and Thin Film Mechanics
- Adenosine and Purinergic Signaling
- Assembly Line Balancing Optimization
- Advanced Sensor Technologies Research
Sun Yat-sen University
2022-2025
Emory University
2023-2025
University College London
2023-2025
Sun Yat-sen University Cancer Center
2025
Beijing Institute of Technology
2025
Xi'an Polytechnic University
2024
China Industrial Control Systems Cyber Emergency Response Team
2022
Glidewell (United States)
2021-2022
National Earthquake Response Support Service
2022
Shenyang Jianzhu University
2022
Immune checkpoint blockade (ICB) therapy potently revives T cell's response to cancer. However, patients suffered with tumors that had inadequate infiltrated immune cells only receive limited therapeutic benefits from ICB therapy. Synthetic biology promotes the alternative strategy of harnessing tumor-targeting bacteria synthesize therapeutics modulate immunity in situ. Herein, we engineered attenuated Salmonella typhimurium VNP20009 gene circuits synthetize granulocyte-macrophage...
Dendritic cells (DCs) can form a T cell niche in tumor microenvironment and drive proliferation through immunostimulatory ligands. However, hypoxia severely hinders the infiltration of immune cells, thus restricting cells' anti-tumor response. Microalgae have evolved an efficient photosynthesis system that might be promising oxygen source to mitigate hypoxia. Here, we combine Chlorella vulgaris genetically engineered DC membrane, overexpressing necrosis factor (TNF) ligand proteins OX40L,...
An important factor in the development of type 1 diabetes (T1D) is deficiency inhibitory immune checkpoint ligands, specifically programmed cell death ligand (PD-L1) and galectin-9 (Gal-9), β-cells. Therefore, modulation pancreas-infiltrated T lymphocytes by exogenous PD-L1 or Gal-9 an ideal approach for treating new-onset T1D. We genetically engineered macrophage cells to generate artificial extracellular vesicles (aEVs) overexpressing Gal-9, which could restrict islet autoreactive protect...
Inactivated tumor cells preserve a whole spectrum of antigens, including neoantigens that can elicit potent immune response. Nevertheless, avoiding tumorigenic risks while stimulating robust anti-tumor response remains pivotal challenge. Herein, we prepare enucleated cancer decorated with bacteria-derived vesicles (BDVs) carrying stimulator interferon gene (STING) agonists as live cell vaccines. Enucleated retain intact morphology excepting the nucleus. BDVs loaded STING agonist cyclic...
How does the brain support 'wellbeing'? Because it is a multidimensional construct, likely product of multiple co-active networks that vary across individuals. This perhaps why prior neuroimaging studies have found inconsistent anatomical associations with wellbeing. Furthermore, these used 'laboratory-style' or 'resting-state' methods not amenable to finding manifold networks. To address issues, we had participants watch full-length romantic comedy-drama film during functional magnetic...
The hemispherical resonant gyroscope is the highest-precision solid-state vibration gyroscope, widely applied in aviation, aerospace, marine, and other navigation fields. As core component of design its structural parameters directly influences key performance resonator—specifically, thermoelastic damping quality factor minimum frequency difference from interference modes—affecting operational accuracy lifespan gyroscope. However, existing research, both domestic international, has not...
Autoimmune destruction of pancreatic β-cells leads to impaired insulin production and onset type 1 diabetes (T1D). Hence, immunomodulation pancreas-infiltrated immune cells especially the autoreactive-T is a promising way hinder reverse progress T1D. Herein, megakaryocytes are primed with interferon-γ (IFN-γ) produce platelets presenting high levels immunosuppressive checkpoint ligands including programmed death-ligand (PD-L1), Programmed Death-Ligand 2 (PD-L2), B T lymphocyte attenuator...
To evaluate a newly developed self-adhesive resin cement on physical, mechanical, and adhesive properties compare it with other commercial cements.Experimental (SARC) was formulated by our proprietary filler technology. Maxcem Elite, RelyX Unicem 2, SpeedCem Plus, SmartCEM Calibra Universal 2 were selected for comparison. Working setting times, film thickness, water sorption solubility, flexural strength, modulus measured in accordance ISO-4049. Consistency tested according to modified ISO...
The process of complex cognition, which includes language processing, is dynamic in nature and involves various network modes or cognitive modes. This can be manifested by a set brain states transitions between them. Previous neuroimaging studies have shed light on how bilingual brains support native (L1) second (L2) through shared network. However, the mechanism this enables L1 L2 processing remains unknown. study examined issue testing hypothesis that associated with distinct state...
<p dir="ltr"><a href="" target="_blank">An important factor in the development of Type 1 diabetes (T1D) is deficiency inhibitory immune checkpoint ligands, specifically programmed cell death ligand (PD-L1) and Galectin-9 (Gal-9), <i>β</i>-cells. Hence, modulation pancreas infiltrated T lymphocytes by exogenous PD-L1 or Gal-9 an ideal approach for treating new-onset T1D. Herein, we genetic engineered macrophage cells to generate </a><a...
Messaging is a ubiquitous digital communication medium. It also minimal medium of because its inability to convey immediate feedback, tone, facial expressions, hesitations, and pauses, or follow the train other person's thoughts. This paper combines quantitative qualitative approaches for analyzing richer forms typing indicators in messaging interfaces, such as showing text it typed. By assessing users' subjective workload interpreting these findings context experiences, we found that more...
A novel structure of braided composite pressure vessel (BCPV) is designed in this paper. Based on the overall geometry preform, representative volume unit (RVU) model established. The effective elastic constants and mechanical properties layer BCPV are predicted, compared with filament-wound (FWPV). Numerical results show that can effectively improve vessel, has a wide application prospect.
<p dir="ltr"><a href="" target="_blank">An important factor in the development of Type 1 diabetes (T1D) is deficiency inhibitory immune checkpoint ligands, specifically programmed cell death ligand (PD-L1) and Galectin-9 (Gal-9), <i>β</i>-cells. Hence, modulation pancreas infiltrated T lymphocytes by exogenous PD-L1 or Gal-9 an ideal approach for treating new-onset T1D. Herein, we genetic engineered macrophage cells to generate </a><a...
<p dir="ltr"><a href="" target="_blank">An important factor in the development of Type 1 diabetes (T1D) is deficiency inhibitory immune checkpoint ligands, specifically programmed cell death ligand (PD-L1) and Galectin-9 (Gal-9), <i>β</i>-cells. Hence, modulation pancreas infiltrated T lymphocytes by exogenous PD-L1 or Gal-9 an ideal approach for treating new-onset T1D. Herein, we genetic engineered macrophage cells to generate </a><a...
As a new industry integrated by computing, communication, networking, electronics, and automation technology, the Internet of Vehicles (IoV) has been widely concerned highly valued at home abroad. With rapid growth number intelligent connected vehicles, data security risks IoV have become increasingly prominent, various attacks on emerge in an endless stream. This paper firstly introduces latest progress policies, regulations, standards, technical routes major countries regions,...
In this paper, the thermal calculation and thermal-structural coupling analysis of vertical machining center are carried out to obtain theoretical values generation displacement. Combined with structure center, sensors placed at key positions large displacement measure analyze error data, law temperature deformation is found out. This research provides basis for compensation.