A5024705369- Developmental Biology and Gene Regulation
- Retinal Development and Disorders
- Cell Adhesion Molecules Research
- Wnt/β-catenin signaling in development and cancer
University of Milan
2023-2024
The cohesin complex performs essential cellular functions including regulation of chromosome cohesion, chromatin organization and DNA repair. Somatic pathogenetic variants in genes, such as STAG2, have been associated with cancer, but their contribution to brain tumorigenesis is unclear. Here, we report the presence STAG2 glioblastoma medulloblastoma patients determine that loss human cells leads damage apoptosis. Treatment inhibitors Poly ADP-ribose polymerase (PARP), which are used treat...
The evolutionarily conserved Notch signaling pathway controls cell–cell communication, enacting cell fate decisions during development and tissue homeostasis. Its dysregulation is associated with a wide range of diseases, including congenital disorders cancers. Signaling outputs depend on maturation receptors trafficking to the plasma membrane, endocytic uptake sorting, lysosomal proteasomal degradation, ligand-dependent independent proteolytic cleavages. We devised assays follow...
Abstract The evolutionarily conserved Notch pathway controls cell–cell communication during development and in adult metazoans. It influences cell fate decisions, proliferation differentiation, contributes to the maintenance of normal tissue homeostasis. Consequently, misregulation is associated with a wide range diseases, including congenital disorders cancers little no cure. Signaling by receptors regulated complex set cellular processes that include maturation trafficking plasma membrane,...