A5103231449- DNA and Nucleic Acid Chemistry
- Retinal and Optic Conditions
- RNA and protein synthesis mechanisms
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- DNA Repair Mechanisms
- Advanced biosensing and bioanalysis techniques
- DNA and Biological Computing
- Protein Structure and Dynamics
- Chemical Synthesis and Analysis
- Assisted Reproductive Technology and Twin Pregnancy
- Synthesis and Characterization of Heterocyclic Compounds
- Cardiac Imaging and Diagnostics
- Advanced NMR Techniques and Applications
- Cancer therapeutics and mechanisms
- Amino Acid Enzymes and Metabolism
- Chemical Reactions and Isotopes
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Various Chemistry Research Topics
- Systemic Lupus Erythematosus Research
- Mercury impact and mitigation studies
- Mesoporous Materials and Catalysis
- Retinal Development and Disorders
- Melanoma and MAPK Pathways
Universidad de Valladolid
2022-2023
Garrahan Hospital
2006
State University of New York
1998
Stony Brook University
1998
Columbia University
1989-1992
University of Buenos Aires
1984-1990
We have synthesized, separated, and purified approximately 10 mg of a deoxyundecanucleotide duplex containing single centrally positioned covalent adduct between (+)-anti-benzo[a]pyrene (BP) diol epoxide the exocyclic amino group guanosine. Excellent proton NMR spectra are observed for (+)-trans-anti-BP epoxide-N2-dG opposite dC flanked by G.C pairs in d[C1-C2-A3-T4-C5-(BP)G6-C7-T8-A9-C10-C11].d[12- G13-T14-A15-G16-C17-G18-A19-T20-G 21-G22] +ADdesignated (BP)G.C 11-mer+BD. determined...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNMR studies of DNA (R+)n.cntdot.(Y-)n.cntdot.(Y+)n triple helixes in solution: imino and amino proton markers T.cntdot.A.cntdot.T C.cntdot.G.cntdot.C+ base-triple formationCarlos De los Santos, Mark Rosen, Dinshaw PatelCite this: Biochemistry 1989, 28, 18, 7282–7289Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://doi.org/10.1021/bi00444a021RIGHTS & PERMISSIONSArticle...
[5,8-13C2]Spermidine was prepared by synthesis, and its binding to macromolecular structures of Escherichia coli studied. When added E. cells, the two signals [13C]spermidine (C-5, 47.8 ppm, C-8, 39.6 ppm; JC-C = 5.8 Hz) were strongly broadened due macromolecules. tRNA, C-5 resonance v1/2 4.7 Hz, whereas C-8 2.7 Hz. tRNA-bound could be chased [12C]spermidine or spermine, but not putrescine cadaverine. By using mixtures [5-13C]- [8-13C]spermidines (where 13C-13C coupling avoided), it possible...
Translesional DNA synthesis past abasic sites proceeds with the preferential incorporation of dAMP opposite lesion and, depending on sequence context, one or two base deletions. High-resolution NMR spectroscopy and molecular dynamics simulations were used to determine three-dimensional structure a heteroduplex containing synthetic site (tetrahydrofuran) residue positioned in that promotes Analysis spectra indicates stem region duplex adopts right-handed helical glycosidic torsion angle is...
Objectives: The purpose of this study is to define the prevalence Septo-Optic Dysplasia (SOD) in a group patients with Optic Nerve Hypoplasia (ONH) and clinical spectrum SOD.