A5000794626- Virus-based gene therapy research
- Viral Infections and Outbreaks Research
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Viral Infectious Diseases and Gene Expression in Insects
- Organ Donation and Transplantation
- Methemoglobinemia and Tumor Lysis Syndrome
- Immune Cell Function and Interaction
- Eicosanoids and Hypertension Pharmacology
- Organ and Tissue Transplantation Research
- Organ Transplantation Techniques and Outcomes
- Nitric Oxide and Endothelin Effects
- RNA Interference and Gene Delivery
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- interferon and immune responses
- Plant-based Medicinal Research
- Trauma and Emergency Care Studies
- Herpesvirus Infections and Treatments
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Redox biology and oxidative stress
- Poisoning and overdose treatments
- HIV Research and Treatment
Philadelphia College of Osteopathic Medicine
2025
University of America
2017
Catholic University of America
2017
Fondazione Ricerca Molinette
2015
Regione Piemonte
2015
University of Montana
2010-2012
Duke Medical Center
2012
Duke University
2009
Despite substantial evidence that nitric oxide (NO) and/or endogenous S-nitrosothiols (SNOs) exert protective effects in a variety of cardiovascular diseases, the molecular details are largely unknown. Here we show following left coronary artery ligation, mice with targeted deletion S-nitrosoglutathione reductase gene (GSNOR(-/-)) have reduced myocardial infarct size, preserved ventricular systolic and diastolic function, maintained tissue oxygenation. These profound physiological associated...
ABSTRACT A number of New World arenaviruses (Junín [JUNV], Machupo [MACV], and Guanarito [GTOV] viruses) can cause human disease ranging from mild febrile illness to a severe often fatal hemorrhagic fever syndrome. These highly pathogenic viruses the Old Lassa virus pose significant threat public health national security. The only licensed antiviral agent with activity against these viruses, ribavirin, has had mixed success in treating arenaviral is associated toxicities. novel pyrazine...
ABSTRACT The arenavirus envelope glycoprotein (GPC) retains a stable signal peptide (SSP) as an essential subunit in the mature complex. 58-amino-acid residue SSP comprises two membrane-spanning hydrophobic regions separated by short ectodomain loop that interacts with G2 fusion to promote pH-dependent membrane fusion. Small-molecule compounds target this unique SSP-G2 interaction prevent entry and infection. between is sensitive phylogenetic distance New World (Junín) Old (Lassa)...
The α4ß7 integrin present on host cells recognizes the V1V2 domain of HIV-1 envelope protein. This interaction might be involved in virus transmission. Administration α4ß7-specific antibodies inhibit acquisition SIV a macaque challenge model. But molecular details V1V2: are unknown and its importance infection remains controversial. Our biochemical mutational analyses show that glycosylation is key modulator conformation binding to α4ß7. Partially glycosylated, but not fully proteins...
Successful amelioration of cardiac dysfunction and heart failure through gene therapy approaches will require a transgene effective at attenuating myocardial injury, subsequent remodeling, using an efficient safe delivery vehicle. Our laboratory has established well-curated, high-quality repository human tissues that we use as discovery engine to identify putative therapeutic targets, well better understand the molecular basis failure. By this rare resource were able examine age- sex-matched...
Adeno-associated virus type 3b (AAV3b) has been largely ignored by gene therapists because of the inability vectors based on this serotype to transduce target tissues efficiently. Here we describe a phenomenon unique AAV3b in that mediate enhanced transduction presence heparin. Among many biological functions attributed heparin, its interaction with, and ability regulate, several growth factors (GFs) factor receptors (GFRs) well characterized. Using GFR-overexpressing cell lines, soluble GFs...