A5022313682- Salmonella and Campylobacter epidemiology
- Vibrio bacteria research studies
- Bacteriophages and microbial interactions
- Escherichia coli research studies
- Cancer Research and Treatments
- Antibiotic Resistance in Bacteria
- Plant Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Clostridium difficile and Clostridium perfringens research
- Nanoplatforms for cancer theranostics
- Bacterial Identification and Susceptibility Testing
- Vector-Borne Animal Diseases
- Radioactive element chemistry and processing
University of the Americas
2023-2024
Universidad Bernardo O'Higgins
2023-2024
Universidad Mayor
2019-2022
University of Chile
2013-2016
ABSTRACT Salmonella enterica serotype Gallinarum is the causative agent of fowl typhoid, a disease characterized by high morbidity and mortality that causes major economic losses in poultry production. We have reported S . harbors type VI secretion system (T6SS) encoded pathogenicity island 19 (SPI-19) required for efficient colonization chicks. In present study, we aimed to characterize SPI-19 T6SS functionality investigate mechanisms behind phenotypes previously observed vivo Expression...
Abstract The type VI secretion system (T6SS) is a virulence factor for many Gram-negative bacteria. S almonella genus harbors five phylogenetically distinct T6SS loci encoded in Salmonella Pathogenicity Islands (SPIs) SPI-6, SPI-19, SPI-20, SPI-21 and SPI-22, which are differentially distributed among serotypes. T6SSs SPI-6 SPI-19 contribute to pathogenesis of serotypes Typhimurium Gallinarum mice chickens, respectively. Dublin pathogen restricted cattle where it causes systemic disease....
Therapeutic attenuated strains of Salmonella Typhimurium target and eradicate tumors in mouse models. However, the mechanism S. for tumor targeting is still poorly understood. We performed a high-throughput screening single-gene deletion mutants an orthotopic, syngeneic murine mammary model breast cancer. The under selection this system were classified into functional categories to identify bacterial processes involved accumulation within tumors. Niche-specific genes preferential...
The role of the Salmonella Pathogenicity Islands (SPIs) in pathogenesis enterica Typhimurium infection chicken is poorly studied, while many studies have been completed murine models. Type VI Secretion System (T6SS) a recently described protein secretion system Gram-negative bacteria. genus contains five phylogenetically distinct T6SS encoded differentially distributed genomic islands. S. harbors SPI-6 (T6SSSPI-6), which contributes to ability colonize mice. On other hand, serotype...
The Type VI Secretion System (T6SS) is a multiprotein device that has emerged as an important fitness and virulence factor for many Gram-negative bacteria through the injection of effector proteins into prokaryotic or eukaryotic cells via contractile mechanism. While some specifically target bacterial cells, others can both types (trans-kingdom effectors). In Salmonella, five T6SS gene clusters have been identified within pathogenicity islands SPI-6, SPI-19, SPI-20, SPI-21, SPI-22, which are...
The type VI secretion system (T6SS) is a contact-dependent contractile multiprotein apparatus widely distributed in Gram-negative bacteria. These systems can deliver different effector proteins into target bacterial and/or eukaryotic cells, contributing to the environmental fitness and virulence of many pathogens. Salmonella harbors five T6SSs encoded genomic islands. T6SS Pathogenicity Island 6 (SPI-6) contributes competition with host microbiota its interaction infected cells. Despite...
Salmonella Infantis is considered in recent years an emerging serovar, as it has been associated with several outbreaks and multidrug resistance phenotypes. Phages appear a possible alternative strategy to control (SI). The aims of this work were characterize two phages the Felixounavirus genus, isolated using same strain SI, expose them interact challenge assays identify genetic phenotypic changes generated from these interactions. These have shared nucleotide identity 97% are...
Antimicrobial resistance is an increasing problem worldwide, and Salmonella spp. to quinolone was classified by WHO in the high priority list. Recent studies Europe US reported presence of small plasmids carrying Enterobacteriaceae isolated from poultry products. The aims this study were identify characterize plasmid mediated spp., investigate transduction as a possible mechanism associated its dissemination. First, we assessed nalidixic acid / or ciprofloxacin 64 detected 8 them. Genomic...
Type VI Secretion Systems (T6SS), widely distributed in Gram-negative bacteria, contribute to interbacterial competition and pathogenesis through the translocation of effector proteins target cells.
Salmonella genus harbors five Type VI Secretion System (T6SS) gene clusters. The T6SS encoded in SPI-6 (T6SSSPI-6) contributes to Typhimurium colonization of chickens and mice, while the SPI-19 (T6SSSPI-19) Gallinarum chicken colonization. Interestingly, T6SSSPI-19 complemented defect a strain that lacks T6SSSPI-6, suggesting both T6SSs are interchangeable. Here we show transfer mice ΔT6SSSPI-6 strain, indicating functionally redundant during host
ABSTRACT The type VI secretion system (T6SS) is a contact-dependent contractile multiprotein apparatus widely distributed in Gram-negative bacteria. These systems can deliver different effector proteins into target bacterial and/or eukaryotic cells, contributing to the environmental fitness and virulence of many pathogens. Salmonella harbors five T6SSs encoded genomic islands. T6SS Pathogenicity Island 6 (SPI-6) contributes competition with host microbiota its interaction infected cells....