A5041380166- Health, Medicine and Society
- Healthcare Systems and Practices
- Multiculturalism, Politics, Migration, Gender
- Cultural Insights and Digital Impacts
- French Urban and Social Studies
- International Law and Aviation
- Law, logistics, and international trade
- Aging, Elder Care, and Social Issues
- Legal and Labor Studies
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- Mathematics, Computing, and Information Processing
- Social Sciences and Governance
- International Labor and Employment Law
- Information Technology and Learning
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- Power Systems and Technologies
- Agriculture and Rural Development Research
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- Mobile Agent-Based Network Management
- French Language Learning Methods
- Urban and Freight Transport Logistics
Droit et changement social
2012-2021
UCB Pharma (Belgium)
2014-2019
Centre Scientifique et Technique du Bâtiment
2018
Nantes Université
1999-2017
Université Rennes 2
2017
Centre National de la Recherche Scientifique
1999-2017
The synaptic vesicle glycoprotein 2A (SV2A) is found in secretory vesicles neurons and endocrine cells. PET with a selective SV2A radiotracer will allow characterization of drugs that modulate (e.g., antiepileptic drugs) potentially could be biomarker density neurodegenerative disorders). Here we describe the synthesis <sup>11</sup>C-UCB-J ((<i>R</i>)-1-((3-(<sup>11</sup>C-methyl-<sup>11</sup>C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) nonhuman primates, including...
Abstract The role of the synaptic vesicle protein 2A (SV2A) protein, target antiepileptic drug levetiracetam, is still mostly unknown. Considering its potential to provide in vivo functional insights into SV2A epileptic patients, development an positron emission tomography (PET) tracer has been undertaken. Using a 3D pharmacophore model based on close analogues we report rationale design three heterocyclic non‐acetamide lead compounds, UCB‐A, UCB‐H and UCB‐J, first single‐digit nanomolar...
High throughput screening identified a pyrrolidinone containing acidic functionality as CCR2 antagonist of modest affinity. We describe initial SAR around this hit, including solution phase parallel synthesis for analog preparation, and we identification characterization an subsequently selected viable lead molecule further optimization. Keywords: MCP-1, CCR2, Chemokine receptor, Antagonist, Inflammation, Hit to
S’appuyant sur le cas du transport routier de marchandises en France, l’article rend compte processus historique mise forme juridique et sociale d’un régime temporel disponibilité des conducteurs routiers. Ce particulièrement marqué la tension entre mobilisation protection travailleur, est appréhendé sous vocable « temps service ». Emblématique phénomène d’endogénéisation droit, négocié par conflits concertation s’inscrit dans un autre qui relève managérialisation droit : partant engagement...
Condition of Law in Freight Road Transport : Deceptive Rules. The freight road transport sector is a paradoxical situation. It particularly regulated activity. However, at the same time, professionals from this have not implemented numerous legal measures to which they were normally subjugated. So analysis entire set rules cannot procure us precise picture state law Indeed, ineffectiveness badly applied regulations seems hide another reality, more flexible or different how it might first appear.
L’observation des règles appliquées dans une société de transport routier entre les années mille neuf cent quatre-vingt et aujourd’hui fait apparaître transformation notable du rapport au droit entretenu par l’entreprise en matière relations travail. D’abord dominé un refus la législation d’origine étatique prééminence professionnelles coutumières, ce évolue vers prise compte loi. Cependant, plutôt qu’une attitude simplement légaliste, il apparaît que mobilise tel relais ou comme objectif,...