A5021116013- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Olfactory and Sensory Function Studies
- Visual perception and processing mechanisms
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
King's College London
2022-2024
Task-switching is a fundamental cognitive ability that allows animals to update their knowledge of current rules or contexts. Detecting discrepancies between predicted and observed events essential for this process. However, little known about how the brain computes prediction-errors whether neural prediction-error signals are causally related task-switching behaviours. Here we trained mice use switch, in single trial, responding same stimuli using two distinct rules. Optogenetic silencing...
Attentional modulation of sensory processing is a key feature cognition; however, its neural circuit basis poorly understood. A candidate mechanism the disinhibition pyramidal cells through vasoactive intestinal peptide (VIP) and somatostatin (SOM)-positive interneurons. However, interaction attentional VIP-SOM has never been directly tested. We used all-optical methods to bi-directionally manipulate VIP interneuron activity as mice performed cross-modal attention-switching task. measured...
Abstract Task-switching is a fundamental cognitive ability that allows animals to update their knowledge of current rules or contexts. Detecting discrepancies between predicted and observed events essential for this process. However, little known about how the brain computes prediction-errors whether neural prediction-error signals are causally related task-switching behaviours. Here we trained mice use switch, in single trial, responding same stimuli using two distinct rules. Optogenetic...
Abstract Attentional modulation of sensory processing is a key feature cognition, yet its neural circuit basis poorly understood. A candidate mechanism the disinhibition pyramidal cells through vasoactive intestinal peptide (VIP) and somatostatin (SOM) positive interneurons. However, interaction attentional VIP-SOM has never been directly tested. We used all-optical methods to bi-directionally manipulate VIP interneuron activity as mice performed an attention switching task. measured VIP,...