A5082259073- Colorectal Cancer Treatments and Studies
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Cancer Treatment and Pharmacology
- Cardiac, Anesthesia and Surgical Outcomes
- Epilepsy research and treatment
- Gastroesophageal reflux and treatments
- Pediatric Pain Management Techniques
- Biomarkers in Disease Mechanisms
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Chemotherapy-related skin toxicity
- Pancreatic and Hepatic Oncology Research
University of Oxford
2018-2023
Centre for Human Genetics
2021-2023
Centre Hospitalier Universitaire de Rennes
1998
Background The cardiovascular side effects of volatile anesthetics are one the chief causes postoperative complications in children, and infants seem to be at greatest risk for this. This study compared changes equipotent concentrations sevoflurane halothane infants. Methods Thirty classified as American Society Anesthesiologists physical status I or II who required elective surgery were randomized receive either inhalation induction. Cardiovascular echocardiographic data recorded both...
Efficacy of 5-Fluorouracil (5-FU)-based chemotherapy is limited by significant toxicity. Tests based upon variants in the Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines with high level evidence a link to dihydropyrimidine dehydrogenase (DPD) phenotype and 5-FU toxicity are available identify patients at risk severe adverse events (AEs). We previously reported associations between rs1213215, rs2612091, NM_000110.3:c.1906-14763G>A (rs12022243) capecitabine induced...
Este estudo analisou as abordagens terapêuticas para a epilepsia infantil, buscando identificar opções eficazes e seguras de tratamento. Utilizou-se uma revisão integrativa abrangendo estudos publicados entre 1996 2024, em português, inglês espanhol, nas bases PubMed, Scielo Google Scholar. Após triagem 102 artigos, 35 foram selecionados análise detalhada. Os resultados apontam que causada por atividade neuronal anormal, afeta o desenvolvimento neuropsicomotor psicossocial das crianças. As...
WODEY, ERIC; PLADYS, PATRICK; COPIN, CATHERINE; LUCAS, MARIE MADELEINE; CHAUMONT, ANDRA; CARRE, PHILIPPE; LELONG, BERNARD; AZZIS, OLIVIER; ECOFFEY, CLAUDE Author Information
Introduction: 5-Flurouracil (5-FU) based adjuvant chemotherapy, including the 5-FU oral prodrug capecitabine, is commonly used as it extremely effective in increasing survival of stage III colorectal cancer patients and with resectable gastric or breast cancer. Its use however limited by concomitant toxicities that arise some patients. ∼ 50% experience dose limiting toxicity when treated capecitabine a single agent this percentage increases given combination e.g. oxaliplatin. We have tested...
3028 Background: Fluoropyrimidine (FP) based adjuvant chemotherapy (5-Fluorouracil and Capecitabine) increases survival of patients with colorectal breast cancers. However, 1-5 % experience cardiovascular toxicity, which is not explained by variants in the gene encoding dihydropyrimidine dehydrogenase. Methods: We sought genetic determinants FP-induced toxicity performing a genome wide association study NCI-CTCAE graded using samples from QUASAR 2 trial (n=759 cancer (CRC)). Validation...