A5103117335- Antimicrobial Peptides and Activities
- Antibiotic Resistance in Bacteria
- Advancements in Solid Oxide Fuel Cells
- Catalytic Processes in Materials Science
- Transgenic Plants and Applications
- Biochemical and Structural Characterization
- Antimicrobial Resistance in Staphylococcus
- Cancer therapeutics and mechanisms
- Electrocatalysts for Energy Conversion
The University of Adelaide
2024-2025
Hydrogen energy as a clean source has been widely studied in recent years. Catalytic hydrogen combustion (CHC) can be used to reduce nitrogen oxide emissions and improve safety by burning at lower temperature. This review analyzes the effect of hetero/homogeneous reaction mechanism, typical catalyst types (noble metal catalysts, perovskite oxides), support materials (zirconium dioxide, titanium anodic aluminum oxide, γ-alumina, silicon carbide) CHC. The fabrication methods for CHC such...
Antibiotic resistance is an urgent threat to global health, with the decreasing efficacy of conventional drugs underscoring urgency for innovative therapeutic strategies. Antimicrobial peptides present as promising alternatives antibiotics. Gramicidin S one such naturally occurring antimicrobial peptide that effective against Staphylococcus aureus, a minimum inhibitory concentration (MIC) 4 μg/mL (3.6 μM). Despite this potent activity, its significant hemolytic toxicity restricts clinical...
Background/Objectives: Multidrug-resistant Gram-negative ESKAPE pathogens, including E. coli, K. pneumoniae, P. aeruginosa, and A. baumannii, pose a significant global health threat. Gramicidin S, potent cyclic antimicrobial peptide, is largely ineffective against these bacteria, its high haemolytic toxicity limits clinical usage. This study reports on several novel gramicidin S analogues with improved efficacy safety profiles multidrug-resistant bacteria. Methods: A total of 19 derivatives...
The rise of multidrug-resistant bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA), necessitates the development new antibacterial therapies. Antimicrobial peptides offer a promising alternative to conventional antibiotics due their unique mechanisms action. Gramicidin S exhibits potent bactericidal activity against S. aureus, however, high haemolytic toxicity currently limits its application topical use. A series gramicidin analogues is presented with rational...