A5040885240- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- Cancer, Stress, Anesthesia, and Immune Response
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- COVID-19 Clinical Research Studies
- PARP inhibition in cancer therapy
- Cancer Research and Treatments
University of Miami
2024
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by a KRAS-driven inflammatory program and desmoplastic stroma, which contribute to the profoundly chemoresistant phenotype. The tumor stroma contains an abundance of cancer-associated fibroblasts (CAF), engage in extensive paracrine cross-talk with cells perpetuate protumorigenic inflammation. IL1α, pleiotropic, cell–derived cytokine, plays critical role shaping stromal landscape. To provide insights into molecular mechanisms...
<div>Abstract<p>Pancreatic ductal adenocarcinoma (PDAC) is characterized by a KRAS-driven inflammatory program and desmoplastic stroma, which contribute to the profoundly chemoresistant phenotype. The tumor stroma contains an abundance of cancer-associated fibroblasts (CAF), engage in extensive paracrine cross-talk with cells perpetuate protumorigenic inflammation. IL1α, pleiotropic, cell–derived cytokine, plays critical role shaping stromal landscape. To provide insights into...
<p>Supplementary data for flow cytometry gating</p>
<p>Supplementary Data for figure 3</p>
<p>Supplementary data for TCGA analysis in Figure 1 without the normalized tumor cellularity analysis</p>
<p>Supplementary Data for figure 1</p>
<p>Supplementary Data for figure 3</p>
<p>Supplementary Materials and Methods</p>
<p>Supplementary data for flow cytometry gating</p>
<div>Abstract<p>Pancreatic ductal adenocarcinoma (PDAC) is characterized by a KRAS-driven inflammatory program and desmoplastic stroma, which contribute to the profoundly chemoresistant phenotype. The tumor stroma contains an abundance of cancer-associated fibroblasts (CAF), engage in extensive paracrine cross-talk with cells perpetuate protumorigenic inflammation. IL1α, pleiotropic, cell–derived cytokine, plays critical role shaping stromal landscape. To provide insights into...
<p>Supplementary Data for figure 2</p>
<div>Abstract<p>Pancreatic ductal adenocarcinoma (PDAC) is characterized by a KRAS-driven inflammatory program and desmoplastic stroma, which contribute to the profoundly chemoresistant phenotype. The tumor stroma contains an abundance of cancer-associated fibroblasts (CAF), engage in extensive paracrine cross-talk with cells perpetuate protumorigenic inflammation. IL1α, pleiotropic, cell–derived cytokine, plays critical role shaping stromal landscape. To provide insights into...
<p>Supplementary Data for figure 3 and 4.</p>
<p>Supplementary data for figure 5 and 6</p>
<p>Supplementary Data for figure 3</p>
<p>Supplementary Data for figure 3</p>
<p>Supplementary Data for figure 1</p>
<p>Supplementary Data for figure 3 and 4.</p>
<p>Supplementary Figure Legends</p>
<p>Supplementary Data for figure 2</p>
<p>Supplementary data for TCGA analysis in Figure 1 without the normalized tumor cellularity analysis</p>
<p>Supplementary Figure Legends</p>
<p>Supplementary Materials and Methods</p>
<p>Supplementary data for figure 5 and 6</p>
<p>Supplementary Data for figure 3</p>