A5014633184- Natural Antidiabetic Agents Studies
- Catalytic C–H Functionalization Methods
- Analytical Chemistry and Chromatography
- Catalytic Cross-Coupling Reactions
- Pharmacology and Obesity Treatment
- Ovarian function and disorders
- Synthesis and Biological Evaluation
- Diet, Metabolism, and Disease
- Cannabis and Cannabinoid Research
- Oxidative Organic Chemistry Reactions
- Herbal Medicine Research Studies
- Pharmacological Effects of Natural Compounds
- Hormonal and reproductive studies
- Synthesis and Catalytic Reactions
- Phytochemicals and Antioxidant Activities
Central Drug Research Institute
2022-2023
Academy of Scientific and Innovative Research
2023
Weatherford College
2023
Fenugreek seeds are used in numerous marketed herbal formulations with therapeutic benefits. Some of its bioactive components such as 4-hydroxyisoleucine, trigonelline, raffinose, and pinitol reported to possess potential activities, antibacterial, antidiabetic, stomach stimulant, anti-invasive, against hyperandrogenism other allied diseases, including polycystic ovary syndrome. A fully validated, selective, sensitive bioanalytical method for the simultaneous rapid quantification...
Aim: To study the preclinical pharmacokinetics of 4-hydroxy isoleucine (4-HIL) targeted for polycystic ovary syndrome. Methodology: The quantitative bioanalysis 4-HIL in different biological matrices female Sprage-Dawley rats using LC-MS/MS. Results: At 50 mg/kg, had 56.8% absolute oral bioavailability. It was quickly absorbed and distributed various tissues order small intestine > kidney spleen lung liver heart brain after administration. Moreover, 11.07% recovered urine feces within 72 h....
An efficient and novel method has been developed for the synthesis of highly substituted isoquinolines/isoquinolones by Ru(II)-catalyzed intermolecular oxidative annulation benzyl/benzoyl isocyanates with diaryl alkynes in presence Cs2CO3 as base Cu(OTf)2 an oxidant at 120 °C 1 h.
Direct activation of sp 2 C–H bonds by a palladium catalyst has received significant attention in organic chemistry.
Abstract Trigonella foenum graecum (TFG) also known as Fenugreek is a popular herb commonly used spice, flavoring, and medicinal agent. It enriched with bioactive constituents namely pinitol (PT), 4-hydroxy isoleucine (4-HIL), raffinose (RFO) which are proven to be responsible for TFGs health benefits. The current study focuses chemometric guided simultaneous RP-UHPLC method development validation of three phytocomponents using universal refractive index detection (RID) technique quantifying...