A5060684630- MicroRNA in disease regulation
- Circular RNAs in diseases
- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Extracellular vesicles in disease
- Cancer Research and Treatment
- Angiogenesis and VEGF in Cancer
- Biological Research and Disease Studies
- Hedgehog Signaling Pathway Studies
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Cancer-related Molecular Pathways
Soligenix (United States)
2023
Abstract Restoration of the tumor suppressor function tumor-associated p53 mutants, including Y220C substitution, has posed a significant challenge for therapeutic discovery. Here, we describe rezatapopt (PC14586), part series compounds designed to reactivate mutant. These restore by correcting its conformation and enabling it bind DNA activate downstream target genes, thus inducing anti-proliferative changes in cells. Our findings are supported biochemical structural analysis, vitro vivo...
Abstract The sparse vascularity of pancreatic ductal adenocarcinoma (PDAC) presents a mystery: What prevents this aggressive malignancy from undergoing neoangiogenesis to counteract hypoxia and better support growth? An incidental finding prior work on paracrine communication between malignant PDAC cells fibroblasts revealed that inhibition the Hedgehog (HH) pathway partially relieved angiosuppression, increasing tumor through unknown mechanisms. Initial efforts study phenotype were hindered...
<p>WNT Distribution and Expression of Downstream Targets.</p>
<p>Explant cellular populations throughout culture.</p>
<p>Overview of single cell regulatory network analysis.</p>
<p>Single cell analysis of paracrine cascades in KPC PDAC.</p>
<p>Single cell analysis of paracrine cascades in KPC PDAC.</p>
<p>Explant cellular populations throughout culture.</p>
<div>Abstract<p>The sparse vascularity of pancreatic ductal adenocarcinoma (PDAC) presents a mystery: What prevents this aggressive malignancy from undergoing neoangiogenesis to counteract hypoxia and better support growth? An incidental finding prior work on paracrine communication between malignant PDAC cells fibroblasts revealed that inhibition the Hedgehog (HH) pathway partially relieved angiosuppression, increasing tumor through unknown mechanisms. Initial efforts study...
<div>Abstract<p>The sparse vascularity of pancreatic ductal adenocarcinoma (PDAC) presents a mystery: What prevents this aggressive malignancy from undergoing neoangiogenesis to counteract hypoxia and better support growth? An incidental finding prior work on paracrine communication between malignant PDAC cells fibroblasts revealed that inhibition the Hedgehog (HH) pathway partially relieved angiosuppression, increasing tumor through unknown mechanisms. Initial efforts study...
<p>WNT Distribution and Expression of Downstream Targets.</p>
<p>IPI-926 treatment alters cellular composition in the tumor microenvironment.</p>
<p>Explant cellular populations.</p>
<p>Explant cellular populations.</p>
<p>Abrogation of SHH signaling fuels hypersprouting in human and murine PDAC explants.</p>