A5071743992- X-ray Diffraction in Crystallography
- Alkaloids: synthesis and pharmacology
- Crystallization and Solubility Studies
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Chemical Synthesis and Analysis
- Chemical synthesis and alkaloids
- Crystallography and molecular interactions
- Traditional and Medicinal Uses of Annonaceae
- Synthesis and Catalytic Reactions
- Plant-derived Lignans Synthesis and Bioactivity
- Lipid Membrane Structure and Behavior
- Click Chemistry and Applications
- Pharmacological Receptor Mechanisms and Effects
Washington University in St. Louis
2024
University of Health Sciences and Pharmacy
2024
Academy of Scientific and Innovative Research
2016
National Chemical Laboratory
2015-2016
The mu opioid receptor (μOR) is a target for clinically used analgesics. However, adverse effects, such as respiratory depression and physical dependence, necessitate the development of alternative treatments. Recently we reported novel strategy to design functionally selective opioids by targeting sodium binding allosteric site in μOR with supraspinally active analgesic named C6guano. Presently, improve systemic activity this ligand, structure-based design, identifying new ligand RO76 where...
A novel and convenient method utilizing the Aubé reaction to access a new class of compounds that are similar carbocyclic nucleosides is reported. The azido alcohol derived from Vince lactam undergoes with various cyclic ketones give cyclopentenyl-substituted lactams. Upon dihydroxylation, this affords N-cyclopentenyl-lactam in racemic form. Given numerous uses related compounds, we were interested synthesis carbocylic nucleoside mimics. attempts results described herein.
A stereoselective total synthesis of (–)-Nardoaristolone B, a nor-aristolane sesquiterpenoid natural product with an unusual 3/5/6 tricyclic ring system is described. The highlights the present work includes use (+)-(R)-Pulegone as chiral-pool starting material, ring-closing metathesis, allylic oxidation and cyclopropanation. In addition, new analogue Nardoaristolone B (minor from final step) was isolated in pure form fully characterized help single-crystal X-ray analysis.
Abstract Ibogaine and its main metabolite noribogaine provide important molecular prototypes for markedly different treatment of substance use disorders co-morbid mental health illnesses. However, these compounds present a cardiac safety risk highly complex mechanism. We introduce class iboga alkaloids – termed oxa-iboga defined as benzofuran-containing analogs created via structural editing the skeleton. The lack proarrhythmic adverse effects ibogaine in primary human cardiomyocytes show...
<b>Abstract ID 52769</b> <b>Poster Board 538</b> Opioids are used for the treatment of acute to severe pain. Usage opioids also produces liabilities like respiratory depression and addiction, which in combination with illicit use fentanyl designer analogs has contributed opioid epidemic. Most approaches design safer have been restricted targeting orthosteric binding sites. We recently reported a novel strategy functionally selective by sodium allosteric site mu receptor (MOR). The lead...