A5110916077- CAR-T cell therapy research
- Advanced Proteomics Techniques and Applications
- S100 Proteins and Annexins
- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- Microbial Community Ecology and Physiology
- Gut microbiota and health
- Semiconductor materials and devices
- Integrated Circuits and Semiconductor Failure Analysis
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Platelet Disorders and Treatments
- Blood properties and coagulation
- Cancer, Hypoxia, and Metabolism
- Viral Infectious Diseases and Gene Expression in Insects
- Pancreatic function and diabetes
- Environmental DNA in Biodiversity Studies
- Genetic Associations and Epidemiology
- Silicon Carbide Semiconductor Technologies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Acute Lymphoblastic Leukemia research
- Gastrointestinal motility and disorders
- Cancer Research and Treatments
- T-cell and Retrovirus Studies
Nankai University
2021-2025
Chongqing Cancer Hospital
2025
Chongqing University
2025
Beijing Proteome Research Center
2023-2025
Changchun University of Chinese Medicine
2024-2025
Tianjin Medical University
2021-2024
Tianjin First Center Hospital
2022-2024
Jiangxi Normal University
2024
First Affiliated Hospital of Nanchang University
2023
Sun Yat-sen University
2021-2023
Abstract Cutaneous malignant melanoma (hereafter called melanoma) is one of the most aggressive cancers with increasing incidence and mortality rates worldwide. In this study, we performed a systematic investigation tumor microenvironmental genetic factors associated to identify prognostic biomarkers for melanoma. We calculated immune stromal scores patients from Cancer Genome Atlas (TCGA) using ESTIMATE algorithm found that they were closely patients’ prognosis. Then differentially...
In breast cancer, a subset of tumor-initiating cells (TIC) or "cancer stem cells" are thought to be responsible for tumor maintenance, treatment resistance, and disease recurrence. While current cancer cell markers (e.g., CD44(high) /CD24(low/neg) , ALDH positive) have allowed enrichment such cells, they not universally expressed may actually identify distinct TIC subpopulations in the same tumor. Thus, additional functional needed. The STAT3 pathway is critical regulator function normal...
Probiotics have been shown to benefit patients with constipation and depression, but whether they specifically alleviate in depression remains unclear. The aim of this study was investigate the effect Lacticaseibacillus paracasei strain Shirota (LcS), formerly Lactobacillus casei Shirota, on specific etiology gut microbiota depressive regimens. Eighty-two were recruited. subjects consumed 100 mL a LcS beverage (108 CFU/mL) or placebo every day for 9 weeks. After ingesting beverages period,...
Background Chimeric antigen receptor T cell (CAR-T) therapy for relapsed/refractory (r/r) B acute lymphoblastic leukemia (B-ALL) and non-Hodgkin lymphoma (B-NHL) patients has shown promising effects, but side effects such as viral infections have been observed. Methods A total of 45 with r/r B-ALL B-NHL were included in this retrospective study. Patient demographics recorded, the primary endpoint being infection within 3 months post CAR-T treatment. Univariate multivariate logistic...
2552 Background: For locally advanced or metastatic non-small cell lung cancer (NSCLC) patients lacking specific genetic mutations, chemotherapy combined with anti-programmed death-1/programmed death-ligand 1 immunotherapy has become standard first-line treatment enhanced therapeutic efficacy and prolonged survival. However, 40-50% of do not benefit from chemo-immunotherapy develop resistance. Currently, there is a lack predictive biomarkers for the therapy in NSCLC, research on regulatory...
Abstract Background Chimeric antigen receptor (CAR) T cells for refractory or relapsed (r/r) B cell no-Hodgkin lymphoma (NHL) patients have shown promising clinical effectiveness. However, the factors impacting response of CAR-T therapy not been fully elucidated. We here investigate independent influencing efficacy CD19 infusion in treatment r/r B-NHL and to establish an early prediction model. Methods A total 43 were enrolled this retrospective study. The patients’ general data recorded,...
Over the past few decades, immunotherapy has revolutionized modern medical oncology field. Chimeric antigen receptor (CAR)-T cell therapy a promising curative effect in treatment of hematological malignancies. Anti-CD19 CAR-T cells are most mature recently studied and recent years it achieved complete remission rate approximately 90% B-cell acute lymphoblastic leukemia (B-ALL). Although greatly alleviated disease patients with or lymphoma, some them still relapse after treatment. Therefore,...
The ongoing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the emergence different variants concerns with immune evasion that have been prevalent over past three years. Nanobodies, functional variable regions camelid heavy-chain-only antibodies, garnered interest in developing neutralizing antibodies due their smaller size, structural stability, ease production, high affinity, and low immunogenicity, among other characteristics. In this work, we describe...
Abstract The CLL1-targeted chimeric antigen receptor T (CAR-T) cell therapy offers a novel therapeutic approach for refractory or relapsed acute myeloid leukemia (AML).The targeted elimination of tumor cells by CLL1 CAR-T also induces cytotoxic effects on neutrophils, leading to severe granulocytopenia, thereby significantly increasing the risk infectious complications during therapy. However, associated with this strategy have not been comprehensively investigated. objective study was...
Poyang Lake is the largest freshwater lake in China, which boasts unique hydrological conditions and rich biodiversity. In this study, metagenomics technology was used to sequence microbial genome of soil samples S1 (sedimentary), S2 (semi-submerged), S3 (arid) with different water content from wetland, results indicate that three have physicochemical characteristics, their community structure functional gene distribution are also different, resulting separate ecological functions. The...
Poyang Lake is the largest freshwater lake in China, which boasts unique hydrological conditions and rich biodiversity. In this study, metagenomics technology was used to sequence microbial genome of soil samples S1 (sedimentary), S2 (semi-submerged), S3 (arid) with different water content from wetland; results indicate that three have physicochemical characteristics their community structure functional gene distribution are also different, resulting separate ecological functions. The...
Previous studies have demonstrated a correlation between dietary salt intake and stroke; however, there was lack of conclusive evidence regarding causal connection them. We undertook two-sample Mendelian randomization (MR) study to examine their potential association. The genome-wide data for sourced from association that involved 462,630 samples. Genetic instruments stroke were also obtained study, which included 446,696 Both samples European. inverse variance weighting used as the main...
Abstract Background Chimeric antigen receptor-modified T-cells (CAR-T) have shown good clinical benefit in the treatment of patients with refractory or relapsed B-cell non-Hodgkin’s lymphoma (r/r B-NHL). However, factors that influence response to CAR-T therapy are not fully understood. The aim this study is investigate independent influencing efficacy cell infusion r/r B-NHL and establish an early prediction model. Methods A total 43 were enrolled retrospective develop verify accuracy...
Background: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for high-risk B-cell acute lymphoblastic leukaemia (B-ALL) patients, but relapse remains significant cause of treatment failure.Methods: In this post-hoc analysis, we evaluated the feasibility and efficacy prophylactic or preemptive CD19 CAR-T B-ALL patients after allo-HSCT. A cohort 25 received cells to prevent allo-HSCT, their outcomes were compared with contemporary control group 43 who did...