A5007942568- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- Bacteriophages and microbial interactions
- Kidney Stones and Urolithiasis Treatments
- Endometriosis Research and Treatment
- Hereditary Neurological Disorders
- Epigenetics and DNA Methylation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- Circular RNAs in diseases
- Chronic Kidney Disease and Diabetes
- Pediatric Urology and Nephrology Studies
- CRISPR and Genetic Engineering
- Sperm and Testicular Function
- Diamond and Carbon-based Materials Research
- interferon and immune responses
- Food composition and properties
- Retinal Diseases and Treatments
- Systemic Sclerosis and Related Diseases
- Reproductive Biology and Fertility
Southern University of Science and Technology
2022-2025
Northwest A&F University
2021-2025
Beijing Normal University
2017-2024
Weifang Medical University
2007-2024
Fujian Medical University
2022-2024
First Affiliated Hospital of Fujian Medical University
2022-2024
Beijing Proteome Research Center
2014-2024
Jinhua Academy of Agricultural Sciences
2024
Boai Hospital of Zhongshan
2023-2024
Shandong Electric Power Engineering Consulting Institute Corp
2021-2024
Castration-resistant prostate cancer (CRPC) that occurs after the failure of androgen deprivation therapy is leading cause deaths in patients. Thus, there an obvious and urgent need to fully understand mechanism CRPC discover novel therapeutic targets. Long noncoding RNAs (lncRNAs) are crucial regulators many human cancers, yet their potential roles molecular mechanisms poorly understood. In this study, we discovered lncRNA HOXD-AS1 highly expressed cells correlated closely with Gleason...
Precise genome modification in large domesticated animals is desirable under many circumstances. In the past it only possible through lengthy and burdensome cloning procedures. Here we attempted to achieve that goal use of newest genome-modifying tool CRISPR/Cas9. We set out knockin human albumin cDNA into pig Alb locus for production recombinant serum (rHSA). HSA a widely used blood product high demand. show homologous recombination can occur highly efficiently swine zygotes. All 16 piglets...
Our objective was to determine the secular trend in prevalence of type 2 diabetes Shanghai, China.Two consecutive population-based surveys for were conducted randomly selected adults aged 35-74 years Shanghai 2002-2003 (n = 12,329) and 2009 7,423). Diagnosed determined based on self-report, whereas those undiagnosed identified by measured fasting postload glucose according American Diabetes Association criteria.Age-standardized diagnosed increased from 5.1 4.6% 7.4 5.2% 2009. The with age...
Abstract Localized scleroderma (LoS) is a rare chronic disease with extensive tissue fibrosis, inflammatory infiltration, microvascular alterations, and epidermal appendage lesions. However, deeper understanding of the pathogenesis treatment strategies LoS currently limited. In present work, proteome map skin established, pathological features are characterized. Most importantly, human‐induced pluripotent stem cell‐derived epithelial mesenchymal (EM) organoids model in 3D culture system for...
CpG islands (CGIs) are key regulatory DNA elements at most promoters, but how they influence the chromatin status and transcription remains elusive. Here, we identify characterize SAMD1 (SAM domain-containing protein 1) as an unmethylated CGI-binding protein. has atypical winged-helix domain that directly recognizes CpG-containing via simultaneous interactions with both major minor groove. The SAM interacts L3MBTL3, it can also homopolymerize into a closed pentameric ring. At genome-wide...
We investigated the relationship of kidney calculi with plasma free and total testosterone, androgen receptor up-regulation in kidneys men nephrolithiasis.Male patients stone healthy were included study. Blood was collected a tube containing 2% heparin morning. Total serum testosterone measured by enzyme linked immunosorbent assay. All underwent percutaneous nephrostolithotomy. At end procedure ultrasound guided puncture biopsy done to acquire tissue. Normal tissue obtained at autopsy served...
Accumulative studies have demonstrated the close relationship between tumor immunity and pyroptosis, apoptosis, necroptosis. However, role of PANoptosis in gastric cancer (GC) is yet to be fully understood.This research attempted identify expression patterns regulators immune landscape GC by integrating GSE54129 GSE65801 datasets. We analyzed specimens established molecular clusters associated with PANoptosis-related genes (PRGs) corresponding characteristics. The differentially expressed...
Interaction partners of follicular cells play a significant role in steroidogenesis, formation, and development. Androgen secreted by theca (TCs) can initiate follicle development ovulation provide precursor materials for estrogen synthesis. Therefore, studies on ovarian microenvironment will not only lead to better understanding the steroidogenesis but also have clinical significance endocrine abnormalities such as hyperandrogenism polycystic ovary syndrome (PCOS). This study applied...
The transportation is a crucial phase in beef cattle industry, and the annual losses caused by transport stress are substantial. Several studies have described effect of long distance on animal health, such as disorder nervous, endocrine, immune, metabolic system. However, molecular mechanisms underlying short still poorly understood. Present study aims to investigate measuring hematological indices transcriptomic analysis. In this study, total 10 Qinchuan were used compare characteristics...
Abstract In bacteria, spontaneous mRNAs degradation and ribotoxin-induced RNA damage are two main biological events that lead to the stall of protein translation. The ubiquitous trans-translation system as well several alternative rescue factors (Arfs) responsible for rescuing stalled ribosomes caused by truncated lack stop codons. To date, release factor homolog (PrfH) is only known ribosome damaged ribotoxins. Here we show a subfamily PrfH, exemplified PrfH from Capnocytophaga gingivalis (...
A cocrystallization technique was utilized to improve the performance of lobaplatin, and five cocrystals lobaplatin with a variety flavonoids, including quercetin, myricetin, fisetin, naringenin, luteolin, were successfully obtained. The solubility, dissolution, stability further evaluated, results presented that have reduced solubilities, slow-release rates, delayed hydrolysis performances compared lobaplatin. Meanwhile, solubilities dissolution rates flavonoids dramatically improved. In...
Anti-folate drug pemetrexed is a vital chemotherapy medication for non-small cell lung cancer (NSCLC). Its response varies widely and often develops resistance to the treatment. Therefore, it urgent identify biomarkers establish models efficacy evaluation prediction rational use.A total of 360 subjects were screened 323 recruited. Using metabolomics in combination with machine learning methods, we are trying select potential diagnose NSCLC evaluate treating NSCLC. Furtherly, measured...
The polymerase-associated factor 1 (Paf1) complex is a general transcription elongation of RNA polymerase II, which composed five core subunits, Paf1, Ctr9, Cdc73, Leo1, and Rtf1, functions as diverse platform that broadly affects gene expression genome-wide. In this study, we solved the 2.9-Å crystal structure region Ctr9-Paf1-Cdc73 ternary from thermophilic fungi, provides structural perspective molecular details organization interactions involving Paf1 subunits in complex. We find Ctr9 21...