Abstract Background Tyrosine kinase inhibitors (TKIs) such as sunitinib are multitarget antiangiogenic agents in clear cell renal carcinoma (ccRCC). They widely used the treatment of advanced/metastatic cancer. However, resistance to TKIs is common clinic, particularly after long-term treatment. YTHDC1 main nuclear reader protein that binds with m 6 A regulate splicing, export and stability mRNA. specific role corresponding mechanism cancer cells still unclear. Methods The Cancer Genome...

Metal-organic frameworks (MOFs) are composed of both organic linkers and metallic ions, which have emerged as excellent drug delivery agents for the treatment cancer other diseases. Currently, MOF studies mainly focused on intravenous administration, while dedicated to oral administration relatively scarce. In this study, five MOFs, namely UiO-66, UiO-66-NH2, UiO-66-COOH, UiO-67 Zr-NDC, were synthesized, Zr-NDC had largest loading capacity 5-FU. Next, a chitosan (CS) modified was developed...

An environmentally friendly approach for the comprehensive utilization of shrimp shell waste was reported. Instant catapult steam explosion (ICSE) employed pretreatment. After ICSE, lower crystallinity and greater surface areas shells were achieved, which significantly enhanced extraction chitin. Compared to traditional method, weaker organic acid (HCOOH) much dosages KOH (90% molar less) used, chitin with a high demineralization rate (98.2%) deproteinization (97.7%) obtained. The wastewater...

Criminals are using every means available to launder the profits from their illegal activities into ostensibly legitimate assets. Meanwhile, most commercial anti-money laundering systems still rule-based, which cannot adapt ever-changing tricks. Although some machine learning methods have been proposed, they mainly focused on perspective of abnormal behavior for single accounts. Considering money often involved in gang criminals, these not intelligent enough crack down criminal gangs...

The long non‑coding RNA (lncRNA) X inactive specific transcript (XIST) has recently been reported to promote the malignant progression of bladder cancer through regulating several microRNAs (miRs), including miR‑124, miR‑139‑5p and miR‑200c. However, whether other miRs are also involved in this process remained be determined. present study demonstrated that XIST was significantly upregulated tissues compared with adjacent normal tissues. Furthermore, its expression reduced common cell lines....

Exogenic deposits are an important source of rare earth elements (REEs), especially heavy REEs (HREEs). It is generally accepted that microorganisms able to dissolve minerals and mobilize in supergene environments. However, little known about the roles formation exogenic such as regolith-hosted REE HREE enrichment provide over 90% global demand. In this study, we characterized microbial community composition diversity along a complete weathering profile drilled from deposit Southeastern...

Potassium-metal batteries (PMBs) are attractive candidates for low-cost and large-scale energy storage systems due to the abundance of potassium. However, its application is hampered by large volume change serious dendrite growth. Herein, a CoZn semicoherent structure nanoparticle-embedded nitrogen-doped hollow carbon tube (CoZn@HCT) electrode prepared via coaxial electrospinning. Due high potassiophilic nanoparticles potassium metal space, free-standing CoZn@HCT host K exhibits uniform...

Abstract Aberrant glucose metabolism is a characteristic of bladder cancer. Hyperglycemia contributes to the development and progression However, underlying mechanism by which hyperglycemia promotes aggressiveness cancers, especially cancer, still incompletely understood. N6-methyladenosine (m 6 A) modification kind methylation occurring at N6 position adenosine that important for pathogenesis urological tumors. Recently, it was found m A reader YTHDC1 regulated high-glucose conditions. In...

The multi-functional nanoparticle HN@Cu-MOF integrates PDT/CDT/GT, leading to a significant enhancement in GSH consumption and an elevation ROS production, initiating the sensitization PDT cell apoptosis treatment of tumors.

Porous polymer metal–organic frameworks (MOFs), having the characteristics of large specific surface area, high porosity, and drug load, are used in field medicine. In order to explore feasibility MOFs load drugs, we have made an attempt analyze loading at molecular level. provide sufficient theoretical support for realistic research, especially terms adsorption sites capacity, selected five MOFs, UiO‐66, UiO‐66‐NH2, UiO‐66‐COOH, UiO‐67, UiO‐66‐NDC, with bendamustine 5‐Fluorouracil (5‐FU) as...

As a kind of information-intensive 3D representation, point cloud rapidly develops in immersive applications, which has also sparked new attention compression. The most popular dynamic methods ignore the characteristics clouds and use an exhaustive neighborhood search, seriously impacts encoder's runtime. Therefore, we propose improved compression means for based on curvature estimation hierarchical strategy to meet demands real-world scenarios. This method includes initial segmentation...

Rapid growth of modern technologies is bringing dramatically increased e-commerce payments, as well the explosion in transaction fraud. Many data mining methods have been proposed for fraud detection. Nevertheless, there always a contradiction that most are irrelevant to sequence, yet sequence-related usually cannot learn information at single-transaction level well. In this paper, new "within→between→within" sandwich-structured sequence learning architecture has by stacking an ensemble...

This paper studies zero-shot anomaly classification (AC) and segmentation (AS) in industrial vision. We reveal that the abundant normal abnormal cues implicit unlabeled test images can be exploited for determination, which is ignored by prior methods. Our key observation product images, image patches could find a relatively large number of similar other while ones only have few patches. leverage such discriminative characteristic to design novel AC/AS method Mutual Scoring (MuSc) does not...

Objective: This study aimed to investigate the effect of central venous-to-arterial carbon dioxide partial pressure difference (Pcv-aCO2) on administration cardiotonic drugs in patients with early-stage septic shock. Methods: A retrospective was conducted 120 suffering from At admission, left ventricular ejection fraction (LVEF) and Pcv-aCO2 were obtained. On premise mean arterial ≥ 65 mm Hg, divided into two groups according treatment approaches adopted by different doctors-control group:...

Criminals are using every means available to launder the profits from their illegal activities into ostensibly "legitimate" assets. Meanwhile, most commercial anti-money laundering systems still rule-based, which cannot adapt ever-changing tricks. Although some machine learning methods have been proposed, they mainly focused on perspective of abnormal behavior for single accounts. Considering money often involved in gang criminals, these not intelligent enough crack down criminal gangs...

Temperature-dependent interband transitions and exciton excitations of sol-gel derived ${\mathrm{CuCr}}_{1\ensuremath{-}x}$${\mathrm{Mg}}_{x}$${\mathrm{O}}_{2}$ $(2%\ensuremath{\le}x\ensuremath{\le}8%)$ films have been investigated by transmittance spectra (8--300 K) photoluminescence (PL) (77--300 K). An abnormal dependence the optical band gap with temperature has found for $x=0.02$ 0.04. At low-temperature region, energy shows a redshift trend decreasing temperature. It is due to strong...