A5022620746- Immunotherapy and Immune Responses
- Endoplasmic Reticulum Stress and Disease
- Radiomics and Machine Learning in Medical Imaging
- Heat shock proteins research
- Renal cell carcinoma treatment
- Circular RNAs in diseases
- MRI in cancer diagnosis
- Cancer Genomics and Diagnostics
- Privacy, Security, and Data Protection
- Ferroptosis and cancer prognosis
- Digitalization, Law, and Regulation
- Intellectual Property Law
Indiana University School of Medicine
2019-2023
Indiana University Bloomington
2022-2023
Indiana University – Purdue University Indianapolis
2019
Abstract Heat shock factor 1 (HSF1) is a stress-responsive transcription that promotes cancer cell malignancy. To provide better understanding of the biological processes regulated by HSF1, here we developed an HSF1 activity signature (HAS) and found it was negatively associated with antitumor immune cells in breast tumors. Knockdown decreased tumor size caused influx several cells, most notably CD8+ T cells. Depletion rescued reduction growth HSF1-deficient tumors, suggesting prevents...
Digital economy has come forth as a stimulator for rapid change in business processes and consumption patterns, with technology companies increasing their market share coming out top performers the global national value chains. The key resource these is data through which they optimise platforms. This led Big Tech to become goliaths, giving them significant competitive edge market. same phenomenon being observed Indian digital market, wherein like Facebook, Apple, Google, Amazon hold...
Abstract Breast cancer is the leading cause of related deaths in women. The presence cytotoxic immune cells, specifically CD8+ T breast tumors associated with better patient outcomes. Our goal to understand mechanisms that regulate infiltration cells. This will turn, improve treatment and enhance overall survival. Utilizing a novel HSF1 activity gene signature, we observed was negatively cells patients. Both CIBERSORT analysis TCGA data as well direct assessment primary specimens...
Abstract Heat shock factor 1 (HSF1) is a stress-responsive transcription that promotes cancer cell malignancy. A novel HSF1 Activity Signature (HAS) was found to be negatively associated with antitumor immune cells in breast tumors. Knockdown of decreased tumor size and caused an influx several cells, most notably CD8+ T cells. Depletion prevented tumors from shrinking after knockdown HSF1, suggesting prevents avoid immune-mediated killing. also suppress expression CCL5, chemokine for...