A5100689420- Organometallic Complex Synthesis and Catalysis
- Radioactive element chemistry and processing
- Analytical chemistry methods development
- Coordination Chemistry and Organometallics
- Synthesis and Characterization of Heterocyclic Compounds
- Analytical Chemistry and Chromatography
- Forensic Toxicology and Drug Analysis
- Synthesis of Tetrazole Derivatives
- Boron Compounds in Chemistry
- Chemical Synthesis and Analysis
- Metal-Organic Frameworks: Synthesis and Applications
- Organoboron and organosilicon chemistry
- Synthesis and characterization of novel inorganic/organometallic compounds
- Nanoplatforms for cancer theranostics
- Chromatography in Natural Products
- Radiopharmaceutical Chemistry and Applications
- Luminescence Properties of Advanced Materials
- Catalytic Cross-Coupling Reactions
- Catalytic Alkyne Reactions
- Multicomponent Synthesis of Heterocycles
- Dye analysis and toxicity
- Boron and Carbon Nanomaterials Research
- Membrane Separation and Gas Transport
- Adsorption, diffusion, and thermodynamic properties of materials
- Chemical Synthesis and Reactions
Beijing National Laboratory for Molecular Sciences
2021-2024
Peking University
2021-2024
Chinese Academy of Geological Sciences
2024
China University of Geosciences (Beijing)
2024
Tiangong University
2022
Nanjing University
2019
Wuhan University
2017
Shanghai Institute of Organic Chemistry
2014-2016
Chinese Academy of Sciences
2014-2016
State Council of the People's Republic of China
2016
Accurate diagnosis and therapy are challenging because most diseases lack a single biomarker that distinguishes them from other disorders. A solution would enhance targeting accuracy by using AND-gated combinations of two disease-associated stimuli. Here, we report novel "AND" molecular logic gate, enabling double-controlled release intact functional molecules. Benefiting significant difference in intramolecular cyclization rate, cargo occurs notably faster with the presence both According...
Metal fluoride nanocrystals are widely used in biomedical studies owing to their unique physicochemical properties. The release of metal ions and fluorides from is intrinsic due the solubility equilibrium. It be considered as a drawback because it related decomposition defunction nanocrystals. Many strategies have been developed stabilize nanocrystals, equilibrium concentrations often <1 mM. Here we make good use this minimum amount unveil that could effectively induce desilylation cleavage...
The first boratabenzene derivatives of rare-earth metal hydrides were synthesized, and their reactivity was studied.
Abstract Summary: Solketal acrylate (SA) was homopolymerized by atom transfer radical polymerization (ATRP) using CuBr/ N , ′, ″, ″‐pentamethyldiethylenetriamine as the catalyst and cyclohexanone solvent with controlled molecular weights low polydispersities. The prepared bromine‐terminated homopolymers, PSA, were used macroinitiators to initiate of tert ‐butyl ( t BA) under similar ATRP conditions produce diblock copolymers, PSA‐ b ‐P BA, SA P BA macroinitiator also carried out BA‐ ‐PSA,...
A silicon-bridged boratabenzene fluorenyl ligand [Me2Si(C13H8)(C5H4BNEt2)]2– (L2–) was designed and synthesized. By employment of this ligand, two divalent rare-earth metal complexes [Me2Si(C13H8)(C5H4BNEt2)]Ln(THF)2 (Ln = Sm (1), Yb (2)) were obtained from salt metathesis K2[Me2Si(C13H8)(C5H4BNEt2)] (K2L) with LnI2(THF)2 in THF. Complex 2 undergoes redox reaction cyclooctatetraene to give a trivalent complex [(C8H8)Yb]2[μ-{Me2Si(C13H8)(C5H4BNEt2)}2] (3), accompanied oxidative coupling...
Rare-earth elements include scandium, yttrium and fifteen lanthanides.Since Wilkinson Birmingham reported the fist example of rare-earth organometallic complex, chemistry complexes has had a great advance during past sixty years.A variety Cp containing metal complexes, including mono-Cp, bis-Cp, tri-Cp have been synthesized.Variation size substituent on ring, introducing nitrogen or oxygen pendant arm to ring using ansa bis-Cp ligands make synthesis stabilization these three types...
A series of tris(boratabenzene) lanthanum complexes were synthesized and structurally characterized. Salt elimination anhydrous LaCl3 with Li[C5H5BR] (R = H, NEt2) provided [C5H5BH]3LaLiCl (1) [C5H5BNEt2]3LaLiCl(THF) (2) in high yields. Hydroboration 1-hexene or 3-hexyne 1 gave the alkyl- alkenyl-functionalized boratabenzene complexes, [C5H5B(CH2)5CH3]3LaLiCl(THF) (3) [C5H5BC(C2H5)═CH(C2H5)]3LaLiCl(THF) (4), good N,N′-diisopropylcarbodiimide monohydroboration product...
Here we describe a new method for preparing protein‐imprinted polymer with cloned bacterial protein template, which recognizes/adsorbs authentic target present at relatively low level in cell extract. In this work, pig cyclophilin 18 (pCyP18) was used as template. The template selectively assembled memory molecules from their library, consists of numerous limited length chains randomly distributed recognition sites and immobilizing sites. These assemblies were adsorbed by porous polymeric...
Abstract 1,3‐Azaprotio transfer of propargylic α‐ketocarboxylate oximes, a new type alkynyl oximes featuring an ester tether, has been explored by taking advantage gold catalysis. The incorporation oxygen atom to the chain led formation two different oxa‐cyclic nitrones. It was found that internal with E ‐configuration deliver five‐membered nitrones, whereas terminal afford six‐membered DFT calculations on four possible pathways supported stepwise C−N and C−H bonds, in which...
Mass-independent fractionation during Zn isotope analysis by MC-ICP-MS is identified, which responsible for the sensitive DS ratio effect. Using correction method proposed, results obtained are consistent with theoretical predictions.
Abstract Solvothermal reactions of 4‐cyanopyridine N ‐oxide, NaN 3 , and hydrated M Cl 2 ( = Cu, Co) in a mixture EtOH/H O afford the 3D polymer [Cu I (4‐ptz)] n 1 ) mononuclear complex [Co II (4‐ptz) (H O) 4 ] (4‐ptz 5‐(4‐pyridine ‐oxide) tetrazolate). The crystal structures both compounds were determined by X‐ray crystallography, which ligand 4‐ptz exhibited different coordination modes. thermal stability was measured thermogravimetric analysis (TGA) solid state luminescence property...
Abstract Trifluoroborate boronophenylalanine (BBPA) is a boron amino acid analog of 4‐boronophenylalanine (BPA) but with trifluoroborate group (−BF 3 − ) instead carboxyl (−COOH). Clinical studies have shown that 18 F−labeled BBPA ([ F]BBPA) can produce high‐contrast tumor images in positron emission tomography (PET). Beyond PET imaging, theranostic agent for neutron capture therapy (BNCT). Because possesses an identical chemical structure to BNCT and PET, it potentially predict the...
Abstract Trifluoroborate boronophenylalanine (BBPA) is a boron amino acid analog of 4‐boronophenylalanine (BPA) but with trifluoroborate group (−BF 3 − ) instead carboxyl (−COOH). Clinical studies have shown that 18 F−labeled BBPA ([ F]BBPA) can produce high‐contrast tumor images in positron emission tomography (PET). Beyond PET imaging, theranostic agent for neutron capture therapy (BNCT). Because possesses an identical chemical structure to BNCT and PET, it potentially predict the...
Abstract The emerging strategies of accelerating the cleavage reaction in tumors through locally enriching reactants is promising. Yet, applications are limited due to lack tumor‐selectivity for most reactants. Here we explored an alternative approach leverage rate constant by inducing vivo catalyst. We found that desilylation‐induced chemistry could be catalyzed cationic micelles, and accelerated over 1400‐fold under physiological condition. This micelle‐catalyzed controlled release...