Introduction: Hepatic fibrosis secondary to iron overload in beta-thalassaemia is a known complicating factor. Liver biopsy considered the gold standard; however, it burdened with multitude of risks, highlighting need for ongoing studies evaluate risk using less invasive methods. Aim: To diagnostic utility non liver parameters such as Aspartate Aminotransferase Platelet Ratio Index (APRI) and Fibrosis-4 (FIB-4) detecting fibrosis, well potential YKL-40 (tyrosine (Y), lysine (K), leucine (L))...

A BSTRACT Aicardi syndrome is a rare genetic reported exclusively in females, with incidence of approximately 1 1.1 lakh live births. The clinical condition comprises triad infantile spasms, and mental retardation neuroimaging findings complete corpus callosum, agenesis presence chorioretinal degeneration observed during on eye examination. Here, authors the case 2-year-old female who exhibited typical features, including seizures, developmental delay, distinctive ocular abnormalities. MRI...

Aim The aim of this study was to investigate the utility serum resistin levels as a prognostic indicator for mortality in neonates diagnosed with sepsis. Methodology This one-year prospective at Pandit Bhagwat Dayal Sharma Post Graduate Institute Medical Sciences (PGIMS), Rohtak, India, included 151 categorized into two groups based on blood culture results: group 1 (n=86) those culture-negative, probable sepsis and 2 (n=65) culture-positive, proven Blood samples obtained pre-treatment...

Infantile Tremor Syndrome (ITS) is a complex neurological syndrome that affects exclusively breastfed infants, typically seen between 9 to 12 months of age. However, in the present case, it started at ages three and four months, respectively. ITS characterised by presence megaloblastic anaemia-like features, developmental regression, onset tremors. Here, authors report two cases ITS, whereby anaemia was because drug (phenytoin) intake mothers. Phenytoin mothers leads low serum vitamin B12...

Juvenile Dermatomyositis (JDM) is a rare autoimmune disorder which mainly affects the skin and skeletal muscles. Characteristic features of this include Gottron papules, heliotrope rashes proximal muscle weakness. MDA5 positive JDM usually associated with interstitial lung disease in later part life. The authors report case an 11-year-old male child who presented to Paediatric Department complaints over extensor surfaces, papules pain weakness all limbs. was on treatment from Dermatology as...

To compare efficacy of bepotastine besilate (1.5%) versus alcaftadine (0.25%) in patients with vernal keratoconjunctivitis. This comparative, randomized, single-blind and prospective study was conducted on 100 diagnosed VKC, who were allocated to receive either the two treatment groups. Group A received Alcaftdine eye drops once daily, while B twice daily for 8 weeks. The assessment done at baseline then 4 weeks post-treatment using following parameters - Primary endpoints included clinical...

A BSTRACT Context: Epilepsy is one of the most common chronic neurological disorders in childhood. Structural malformations cerebral cortex are an important cause developmental disabilities and epilepsy; this leads to a significant amount psychological burden on parents such children. Despite being debilitating illness, there paucity data stress depression Aims: The objective was find out these illnesses caregivers Settings Design: This hospital-based cross-sectional, questionnaire-based...

A BSTRACT Cough is a protective reflex that allows clearance of secretions from upper respiratory tract. It not disease by itself but symptom underlying disease. In majority cases, it self-limiting and requires only supportive care. But over-the-counter cough syrups are inadvertently used to relieve in Indian settings. We hereby report case 6-year-old girl child who presented pediatrics emergency services with complaints loss consciousness abnormal body movement after ingestion...

Congenital Adrenal Hyperplasia (CAH) is a group of autosomal recessive disorders that occur due to defects in steroid synthesis. It characterised by deficiency adrenocortical hormones and an excess precursors. A 21-hydroxylase the most common type, constituting 90% cases. The authors hereby, report case one-month-old baby who presented Paediatric Emergency Department with typical features salt-wasting form CAH. diagnosis was confirmed elevated levels 17-hydroxyprogesterone Cytochrome P450...

A BSTRACT Involvement of the heart in children with tuberculosis (TB) generally affects pericardium; however, myocardium a child being affected alone and leading to systolic dysfunction has rarely ever been reported. We report case 12-year-old who presented Pediatric Emergency Services severe hypotension (BP <5 th percentile for age) was subsequently diagnosed left ventricular (LV) dysfunction, an ejection fraction less than 15%. During hospital stay, after exhaustive workup, pulmonary TB...

Ritscher-Schinzel syndrome or Cranio-cerebello-cardiac (3C syndrome) is a rare disorder with autosomal recessive inheritance. Very few reported cases till now (<50 cases) and prevalence of 1 in million live births. It characterized by cardiac defects, central nervous system anomalies like cerebellar hypoplasia, craniofacial anomalies. Exact etiology difficult to understand however mutation chromosome 8q24 coding for strumpellin protein has been found. Index case presented complaints...