A5080840809- Wnt/β-catenin signaling in development and cancer
- Muscle Physiology and Disorders
- Redox biology and oxidative stress
- Cardiomyopathy and Myosin Studies
- Cardiac Arrest and Resuscitation
- Fibroblast Growth Factor Research
- RNA modifications and cancer
- Tissue Engineering and Regenerative Medicine
- Pancreatic and Hepatic Oncology Research
- Vagus Nerve Stimulation Research
- Eicosanoids and Hypertension Pharmacology
- Cancer, Hypoxia, and Metabolism
- Neuropeptides and Animal Physiology
- Nitric Oxide and Endothelin Effects
- Adenosine and Purinergic Signaling
- Cancer Mechanisms and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related gene regulation
Shanxi Medical University
2025
Jinan University
2024
Zhuhai People's Hospital
2024
First Affiliated Hospital of Zhengzhou University
2024
University of Chicago
1996-2006
Vagus nerve stimulation (VNS) exhibits protective effects against remote organ injury following ischemia–reperfusion (I/R). However, its on acute myocardial induced by hepatic I/R in rats, and the underlying mechanisms, remain unclear. Thirty male rats were randomly assigned to five groups: Sham, I/R, VNS, VNS + Erastin, DMSO. A model was established occluding arterial portal veins of left middle lobes liver for 1 h followed 6 reperfusion. performed throughout process. Erastin administered...
The adult ventricular isoform of chicken myosin heavy chain (MHC-V) is transiently expressed in all skeletal muscle primordia analyzed and completely repressed around embryonic days 10-12, when functional innervation established. By ribonuclease protection assay, we demonstrated that denervation the anterior latissimus dorsi resulted reexpression MHC-V mRNA. In contrast, treatment primary cultures fetal breast or leg muscles with brain extract conditioned media from glial neuroblastoma cell...
Aberrant activation of FGFR signaling promotes cancer cell proliferation and tumor growth. Targeting FGFR2/3 selectively may alleviate FGFR1-dependent hyperphosphatemia could provide better efficacy. Here, we evaluated the safety pharmacokinetics a selective potent inhibitor ABSK061 in advanced solid tumors phase 1 open-label study (NCT05244551). As November 2023, total 28 patients with were enrolled escalation part study. These treated twice daily (5mg-100mg BID) or once (150mg QD) 28-day...
<h3></h3> Beta-catenin is a transcriptional coactivator that promotes cell proliferation by induction of genes such as cyclin D1, c-myc, and others. Enhanced b-catenin signaling was observed in many cancer cells vascular smooth muscle (VSMC) during restenosis. The canonical mechanism regulation involves its phosphorylation glycogen synthase kinase 3 (GSK3) targets to ubiquitination degradation the proteasome system. Mitogenic factors promote through inhibition GSK3, resulting reduced...