A5070919642- Molecular Junctions and Nanostructures
- Ionic liquids properties and applications
- CO2 Reduction Techniques and Catalysts
- Gold and Silver Nanoparticles Synthesis and Applications
- Plasmonic and Surface Plasmon Research
- Nanopore and Nanochannel Transport Studies
- thermodynamics and calorimetric analyses
- Cellular Mechanics and Interactions
- Mechanical and Optical Resonators
- Advanced biosensing and bioanalysis techniques
- Advanced Thermoelectric Materials and Devices
- Nanofabrication and Lithography Techniques
- Advanced Fluorescence Microscopy Techniques
- Micro and Nano Robotics
- Force Microscopy Techniques and Applications
- Electrochemical sensors and biosensors
- Lipid Membrane Structure and Behavior
- Microbial Fuel Cells and Bioremediation
- Electrochemical Analysis and Applications
- Ammonia Synthesis and Nitrogen Reduction
Nanjing University
2019-2025
State Key Laboratory of Pollution Control and Resource Reuse
2024-2025
State Key Laboratory of Analytical Chemistry for Life Science
2022
C-C coupling is of utmost importance in the electrocatalytic reduction CO
Measuring binding between molecules is critical for understanding basic biochemical processes, developing molecular diagnosis, and screening drugs. Here we study at the single molecule level by attaching nanoparticles to pairs. We track thermal fluctuations of individual with sub-nanometer precision using a plasmonic scattering imaging technique show that are controlled pairs rather than nanoparticles. Analysis provides unique information on binding, including energy profile, effective...
Enzymes facilitate the conversion of chemical energy into mechanical work during biochemical reactions, thereby regulating dynamic metabolic activity living systems. However, directly observing release facilitated by fluctuating individual enzymes remains a challenge, leading to contentious debate regarding underlying reasons for this phenomenon. Here, we aim overcome challenge developing an oscillating nanomotor powered single-molecule enzyme, which allows real-time tracking transduction in...
Significance Measuring the complete thermodynamic profile of a single molecule reveals unparalleled advantages in biological realm. We develop single-molecule calorimeter with plasmonic imaging and optical tweezer by probing thermal fluctuations nanoparticles linked to substrate via binding pair. This uncovers information for events identifies equilibrium state energetic components free energy landscape, suggesting possibilities offering high-throughout analysis interactions.
Mechanical signals in animal tissues are complex and rapidly changed, how the force transduction emerges from single-cell adhesion bonds remains unclear. DNA-based molecular tension sensors (MTS), albeit successful cellular probing, were restricted by their detection range temporal resolution. Here, we introduced a plasmonic nanosensor (PTNS) to make straight progress toward these shortcomings. Contrary fluorescence-based MTS that only has specific response thresholds, PTNS enabled...
Understanding of DNA-mediated charge transport (CT) is significant for exploring circuits at the molecular scale. However, fabrication robust DNA wires remains challenging due to persistence length and natural flexibility molecules. Moreover, CT regulation in often relies on predesigned sequences, which limit their application scalability. Here, we addressed these issues by preparing self-assembled nanowires with lengths 30–120 nm using structural nanotechnology. We employed plug individual...
Probing of the single-cell level extracellular electron transfer highlights maximum output current for microbial fuel cells (MFCs) at hundreds femtoampere per cell, which is difficult to achieve by existing devices. Past studies focus on external factors boosting charge-extraction efficiency from bacteria. Here, we elucidate intracellular that determine this limit monitoring respiratory-driven shrinking kinetics a single magnetite nanoprobe immobilized Shewanella oneidensis MR-1 cell with...
<title>Abstract</title> C–C coupling is of utmost importance in the electrocatalytic reduction CO2, as it governs selectivity diverse product formation. Nevertheless, difficulties to directly observe pathways on a specific active site hinder advances catalysts and electrolyzer design for efficient high-value hydrocarbon production. Here we develop single-site-resolved Raman technology elucidate influence local electric field evolution C-C intermediates. Through precise adjustments Debye...