A5085221671- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Muon and positron interactions and applications
- Viral Infections and Immunology Research
- Chemical Reactions and Isotopes
- Lymphoma Diagnosis and Treatment
- Organ and Tissue Transplantation Research
- Fuel Cells and Related Materials
- Mechanical Circulatory Support Devices
- Autophagy in Disease and Therapy
- Advanced Breast Cancer Therapies
- Chemical Analysis and Environmental Impact
- Ammonia Synthesis and Nitrogen Reduction
- Chronic Lymphocytic Leukemia Research
- Cellular transport and secretion
- Graphene research and applications
- Lysosomal Storage Disorders Research
- Renal and Vascular Pathologies
Semmelweis University
2023-2025
Eötvös Loránd University
1986-2020
The oral, highly selective Bcl2 inhibitor venetoclax has substantially improved the therapeutic landscape of chronic lymphocytic leukemia (CLL). Despite remarkable response rates in patients with relapsed/refractory (R/R) disease, acquired resistance is leading cause treatment failure, somatic BCL2 mutations being predominant genetic drivers underpinning resistance. To assess correlation between disease progression and most common G101V D103Y, sensitive (10-4) screening for D103Y was...
Background/Objectives: Donor-derived cell-free DNA (dd-cfDNA) is a marker of graft injury that increases in acute rejection and has excellent negative predictive value. Left ventricular global longitudinal strain (LVGLS) strain-derived myocardial work indices are novel echocardiographic parameters with growing applications. Still, they have been poorly investigated heart transplant (HTx) recipients so far. We sought to examine the diagnostic impact left diagnosing as assessed by dd-cfDNA...
Warburg micro syndrome (WMS) is a hereditary autosomal neuromuscular disorder in humans caused by mutations Rab18, Rab3GAP1, or Rab3GAP2 genes. Rab3GAP1/2 forms heterodimeric complex, which acts as guanosine nucleotide exchange factor and activates Rab18. Although the genetic causes of WMS are known, it still unclear whether loss Rab3GAP‐Rab18 module affects neuronal muscle cell physiology both, how. In this work, we characterize mutant Drosophila line to establish novel animal model for...
A szolidszerv-transzplantátum kilökődése a modern immunszuppresszív kezelés mellett is graftdiszfunkció, hospitalizáció és halálozás egyik fő etiológiai tényezője. rejekció diagnosztikájában ’gold standard’ invazív biopszia azonban számos szövődménnyel járhat, interpretálását nagy interobszerver variabilitás jellemzi. megítélésében noninvazív módszerek ezért klinikai jelentőséggel bírnak. graftkárosodást jellemző donoreredetű sejtmentes DNS (dd-cfDNA) recipiens szérumából mutatható ki,...
Donor-derived cell-free DNA (dd-cfDNA) is a blood biomarker detecting graft injury with high negative predictive value. While non-invasive strategies for heart transplant (HTx) rejection surveillance are widely adopted in the United States centralized testing, data on feasibility of dd-cfDNA assay at local level lacking. Here, we report first 6 months experience laboratory-run routine clinical setting.Twenty-six HTx patients stable function were transitioned from endomyocardial biopsy-based...
Abstract Introduction Invasive endomyocardial biopsy (EMB) is still considered the gold standard method for monitoring heart transplant (HTx) rejection. However, it associated with potentially serious complications, and its histopathologic interpretation has high interobserver variability. Thus, noninvasive methods surveillance of transplanted organ remains great interest. The donor-derived cell-free DNA a marker graft injury which can indicate acute rejection, even before histopathological...
Bevezetés: A szívtranszplantátum kilökődése a modern immunszuppresszív gyógyszeres kezelés mellett is graftdiszfunkció, hospitalizáció és halálozás egyik fő etiológiai tényezője. rejekció diagnosztikájában használatos, reguláris surveillance során végzett invazív transzvénás endomiokardiális biopszia (EMB) azonban számos potenciális szövődménnyel bír, interpretálását magas interobszerver variabilitás jellemzi. megítélésében használatos noninvazív eljárások nagy klinikai jelentőséggel bírnak....
Abstract Background Monitoring adverse events is crucial after heart transplantation (HTx). Allograft rejection a major etiological factor of graft dysfunction, hospitalisation, and death posttransplant. Endomyocardial biopsy (EMB) the standard method monitoring rejection; however, there are risks limitations associated with it. The ISHLT guidelines for care HTx recipients have included non-invasive surveillance such as testing donor-derived cell-free DNA (dd-cfDNA). While studies been...