A5032886201- Renal Diseases and Glomerulopathies
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Renal and related cancers
- Chronic Kidney Disease and Diabetes
- Receptor Mechanisms and Signaling
- Renin-Angiotensin System Studies
- Genetic and Kidney Cyst Diseases
- Vasculitis and related conditions
- Renal cell carcinoma treatment
- Neuroscience and Neuropharmacology Research
- Biomedical Research and Pathophysiology
- Retinal Development and Disorders
- Neonatal Respiratory Health Research
- Ion Transport and Channel Regulation
- Pancreatic function and diabetes
- Cardiovascular Effects of Exercise
- Adenosine and Purinergic Signaling
- Gynecological conditions and treatments
- Viral Infections and Immunology Research
- Preterm Birth and Chorioamnionitis
- Ocular Diseases and Behçet’s Syndrome
- Cardiomyopathy and Myosin Studies
- Bladder and Urothelial Cancer Treatments
- Systemic Sclerosis and Related Diseases
Semmelweis University
2014-2025
University of Alabama at Birmingham
2004-2007
Hungarian Academy of Sciences
2003-2007
Pediatric Nephrology of Alabama
2003-2006
Introduction Cardiovascular disease (CVD) is two to five times more prevalent in diabetic patients and the leading cause of death. Therefore, identification novel therapeutic strategies that reduce risk CVD a research priority. Clinical trials showed reduction relative heart failure by sodium-glucose cotransporter 2 inhibitors (SGLT2i) are partly beyond their glucose lowering effects, however, molecular mechanisms still elusive. Here we investigated role SGLT2i dapagliflozin (DAPA)...
Angiotensin (Ang) II directly stimulates epithelial sodium channel activity in the rabbit cortical collecting duct. Because Ang I and converting enzyme analogues might be present distal nephron, this raises possibility of intraluminal generation II. Conversion to was monitored by II-dependent changes intracellular concentration as a reflection transport across apical membrane. This involved imaging-based fluorescence microscopy with sodium-binding benzofuran isophthalate isolated, perfused,...
Recent genetic analysis has identified a pivotal role of primary cilia in the pathogenesis polycystic kidney disease (PKD). However, little is known regarding how loss/dysfunction contributes to cyst development. In epithelial cells, changes apical fluid flow induce cilia-mediated Ca2+ entry via polycystin-2 (PC2), cation channel. The Oak Ridge Polycystic Kidney (orpk) mouse contains mutated Tg737 gene that disrupts expression polaris, protein required for ciliogenesis. These studies examine...
Renal epithelial cells release ATP constitutively under basal conditions and higher quantities of purine nucleotide in response to stimuli. filtered at the glomerulus, secreted by along nephron, released serosally macula densa for feedback signaling afferent arterioles within glomerulus has important physiological roles kidneys. In autosomal recessive polycystic kidney disease (ARPKD) mice humans, collecting duct lack an apical central cilium or express dysfunctional proteins that...
RNA modifications play a fundamental role in cellular function. Pseudouridylation, the most abundant modification, is catalyzed by H/ACA small ribonucleoprotein (snoRNP) complex that shares four core proteins, dyskerin (DKC1), NOP10, NHP2, and GAR1. Mutations DKC1 , NOP10 or NHP2 cause dyskeratosis congenita (DC), disorder characterized telomere attrition. Here, we report phenotype comprising nephrotic syndrome, cataracts, sensorineural deafness, enterocolitis, early lethality two pedigrees:...
To describe the sonomorphological changes and appearance of deep endometriosis (DE) affecting nervous tissue sacral plexus (SP).
Renin release from juxtaglomerular granular cells is considered the rate-limiting step in activation of renin-angiotensin system that helps to maintain body salt and water balance. Available assays measure renin are complex, indirect, work with significant internal errors. To directly visualize study dynamics both tissue activity renin, we isolated perfused afferent arterioles attached glomeruli dissected rabbit kidneys used multiphoton fluorescence imaging. Acidotropic fluorophores, such as...
One component of the macula densa (MD) tubuloglomerular feedback (TGF) signaling pathway may involve basolateral release ATP through a maxi-anion channel. Release has previously been studied during maximal luminal NaCl concentration ([NaCl](L)) stimulus (20-150 mmol/l). Whether MD occurs changes in [NaCl](L) within physiological range (20-60 mmol/l) not examined. Also, because TGF is known to be enhanced by low dietary salt intake, we examined pattern from salt-restricted rabbits....
Transforming growth factor-beta (TGFbeta)-induced epithelial-myofibroblast transdifferentiation is a central mechanism contributing to the pathogenesis of progressive tubulo-interstitial fibrosis. We wanted dissect role extracellular signal-regulated protein kinase (ERK1,2), p38 mitogen-activated (p38 MAPK) and receptor-regulated Smad proteins in regulation alpha-smooth muscle cell actin (alphaSMA) expression, hallmark myofibroblast formation, induced by TGFbeta renal proximal tubular...
Background/Objectives: Donor-derived cell-free DNA (dd-cfDNA) is a marker of graft injury that increases in acute rejection and has excellent negative predictive value. Left ventricular global longitudinal strain (LVGLS) strain-derived myocardial work indices are novel echocardiographic parameters with growing applications. Still, they have been poorly investigated heart transplant (HTx) recipients so far. We sought to examine the diagnostic impact left diagnosing as assessed by dd-cfDNA...
The importance and etiology of meconium-stained amniotic fluid (MSAF) in preterm pregnancies are still poorly understood. Among other factors, intrauterine inflammation is proposed to be a pathophysiological change associated with MSAF. To study the extent inflammation, histological evaluation represents "gold standard" diagnostics. investigate concomitant occurrence MSAF chorioamnionitis (HCA) fetal inflammatory response (FIR). incidence short-term neonatal outcomes infants born from We...
Chronic kidney disease is a global health problem affecting 10% to 12% of the population. Uremic cardiomyopathy often characterized by left ventricular hypertrophy, fibrosis, and diastolic dysfunction. Dysregulation neuregulin-1β signaling in heart known contributor failure. The systemically administered recombinant human for 10 days our 5/6 nephrectomy-induced model chronic alleviated progression uremic dysfunction type 4 cardiorenal syndrome. currently presented positive preclinical data...
Operating under septic conditions poses significant challenges in vascular surgery. Infection is a serious risk when handling synthetic vessel prostheses and one of the most dreaded complications. In event graft infection, an infection-resistant alternative necessary. Cryopreserved allografts offer suitable to replace infected or section graft. However, there are no international guidelines for preparation, storage, thawing such grafts. Here, we aimed investigate mechanical properties human...
The members of the claudin family are major integral transmembrane protein constituents tight junctions. Normal and neoplastic tissues can be characterized by unique qualitative quantitative distribution subtypes, which may related to clinicopathological features. Differential diagnosis prognosis nonmuscle invasive tumor entities urinary bladder epithelium often challenging. aim was investigate expression profile claudins in inverted urothelial papillomas (IUPs), (UPs), papillary neoplasms...
Abstract Objectives To test the accuracy of TVS applying IDEA approach for suspected rectosigmoid DE and to determine frequency other pelvic diseases mimicking in patients undergoing surgery. Materials und Methods Prospective single center observational study including consecutive women clinically followed by conservative or surgical therapy. findings were compared with those obtained laparoscopy confirmed histologically. Results Of 671 included patients, 128 opted medical therapy, 6 decided...
Introduction: The corpus callosum is one of the five main cerebral commissures. It key to combining sensory and motor functions. Its structure can be pathological (dysgenesis) or completely absent (agenesis). dys- agenesis a rare disease (1:4000 live births), but it have serious mental effects. Methods: In our study, we processed data 64 pregnant women. They attended prenatal diagnostic center genetic counseling from 2005 2019 at Department Obstetrics Gynecology Semmelweis University....
Abstract Systematic registration and examination of biopsy-related data in Central Eastern Europe are scarce, while the health condition population is worse compared to other more developed countries. We aim create a database analyze distribution temporal variation renal biopsy diagnoses Hungary, including effect recent coronavirus pandemic. The were standardized according recommendation European Renal Association. Native samples processed between January 1, 2006, December 31, 2020,...
While studying the intracellular calcium dynamics in cells of macula densa, observation was made that tubular epithelial located near densa and associated with renal arterioles exhibit spontaneous Ca2+ oscillations. In this study, cortical thick ascending limb-distal tubule, attached glomerulus, isolated perfused. At a low luminal sodium chloride concentration, oscillations at frequency 63 mHz were observed within 100 microm plaque using four-dimensional multiphoton microscopy wide-field...