A5004042976- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Algal biology and biofuel production
- Insect symbiosis and bacterial influences
- Calcium signaling and nucleotide metabolism
- Solar-Powered Water Purification Methods
- Microbial Fuel Cells and Bioremediation
- Synthesis and Biological Evaluation
- Water Quality Monitoring and Analysis
- Wastewater Treatment and Nitrogen Removal
Experimental Medicine and Biology Institute
2022-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2022-2024
Universitat de València
2024
Pontificia Universidad Católica de Valparaíso
2023
Chagas disease is caused by the parasite Trypanosoma cruzi. In humans, it evolves into a chronic disease, eventually resulting in cardiac, digestive, and/or neurological disorders. present study, we characterized novel T. cruzi antigen named Tc323 (TcCLB.504087.20), recognized single-chain monoclonal antibody (scFv 6B6) isolated from B cells of patients with cardiomyopathy related to disease. Tc323, ~323 kDa protein, an uncharacterized protein showing putative quinoprotein alcohol...
In the chronic phase of Chagas disease (CCD), diagnosis relies on detecting specific IgG antibodies due to low or absent presence parasiteTrypanosoma cruzi in human blood. However, performance current serological tests is highly variable, lacking a "gold standard" assay with 100% sensitivity and specificity, which challenges exploration new biomarkers. present study, we evaluated diagnostic accuracy an optimized ELISA using predicted immunogenic domains (called TcD3 TcD6) Tc323, protein...
Highlights• Biomass retention by membranes enables the reduction of required reactor area.• Combination biological activity and filtration provides great effluent quality.• concentration defines particle deposition on membrane critical flux.
In the pathogen Typanosoma cruzi , calcium ion (Ca 2+ ) regulates key processes for parasite survival. However, mechanisms decoding Ca signals are not fully identified or understood. Here, we investigate role of a hypothetical -binding protein named TcCAL1 in vitro life cycle T. . Results showed that overexpression fused to 6X histidine tag (TcCAL1-6xHis) impaired differentiation epimastigotes into metacyclic trypomastigotes, significantly decreasing metacyclogenesis rates. When virulence...