Polycystic Ovary Syndrome (PCOS) is the most common endocrine-metabolic disorder affecting health and quality of life those affected across lifespan. We currently have limited evidence-based data on experience living with PCOS in care system including diagnosis, concerns disease management. The aim this study was to assess perceptions status, management support by Alberta, Canada.An online questionnaire completed via REDCap individuals self-reporting a diagnosis PCOS. Question categories...

Polycystic ovary syndrome (PCOS) is the most common metabolic-endocrine disorder impacting health and quality of life women over lifespan. Evidence-based data on scope adverse outcomes in those affected by PCOS critical to improve healthcare this population. The aim study was determine prevalence with compared age-matched controls.

The roles of nitric oxide (NO), superoxide anion (O 2 − ), and hydrogen peroxide (H O ) in the modulation spontaneous tone were investigated isolated aorta from deoxycorticosterone acetate (DOCA)‐salt hypertensive rats. Increases preload 1 to 5 g accompanied by increases aortic rings DOCA‐salt rats but not SHAM‐normotensive Tone was higher endothelium‐denuded than endothelium‐intact vessels. Inhibition synthase (NOS) with 300 μ M N G ‐nitro‐ L ‐arginine methyl ester ( ‐NAME) increased tone....

Purpose: Polycystic Ovary Syndrome (PCOS) is a complex endocrine-metabolic disorder and associated with variety of health disorders. The management PCOS requires multidisciplinary care approach. COVID-19 pandemic affected access delivery care. aim this study was to assess the impact on experience those by PCOS. Patients Methods: An online survey conducted January 2021 July 2022 in Canada, open anyone who identified as having Data collected REDCap included questions demographics, symptoms,...

Polycystic ovary syndrome (PCOS) is highly associated with cardiometabolic risk and the metabolic (MetS), predisposing women to increased of developing type 2 diabetes cardiovascular disease. Metformin commonly used treat insulin resistance-glucose intolerance, flutamide, an androgen receptor (AR) antagonist, target hyperandrogenemia dyslipidemia. Currently, physiological mechanism action these treatments on androgen, lipidogenic, signaling pathways remains unclear in PCOS. The aim this...

EndA is a membrane-attached surface-exposed DNA-entry nuclease previously known to be required for genetic transformation of Streptococcus pneumoniae . More recent studies have shown that the enzyme also plays an important role during establishment invasive infections by degrading extracellular chromatin in form neutrophil traps (NETs), enabling streptococci overcome innate immune system mammals. As virulence factor, has become interesting target future drug design. Here we present first...

This study was designed to evaluate the contribution of ATP-dependent potassium (KATP) channels changes in vascular reactivity and spontaneous tone observed vessels isolated from deoxycorticosterone acetate (DOCA)-salt hypertensive rats. In phenylephrine preconstricted aortic rings, cromakalim induced concentration-dependent, glibenclamide-sensitive relaxation. The concentration response curve shifted right DOCA-salt rats (EC50: 0.850 ± 0.100 μM) compared with SHAM-normotensive (0.108 0.005...

The effect of tiron (4,5-dihydroxy-1,3-benzene disulfonic acid) on the binding Ca 2+ and its vascular responses rat perfused mesenteric bed was studied at concentrations that are used widely to scavenge superoxide anion. In competition assays in buffered solutions with no tissue present, decreased fluorescence ratio fura-FF, a measure [Ca ]: inhibition constant (K i ) 0.692 ± 0.036 mM. flow preconstricted 90 mM KCl, evoked decreases perfusion pressure concentration-dependent manner (R max =...

Four hundred and eighty-six patients with myocardial infarction of both sexes comprising 213 Chinese, 53 Malays, 199 Indians, 21 Europeans, resident in Singapore were investigated for differences relative incidence, the ABO, Rh, Le^a, Xg^a blood groups, G6PD deficiency, haemoglobin types. Relative incidence was appreciably higher among Indians than Chinese Malays all age more so younger people. There no significant difference distribution genetic markers between patient...

To compare blood pressure readings obtained with two commonly used oscillometric monitors: Omron HEM 711 AC (OM) and Welch-Allyn 52000 series NIBP/oximeter (WA) mercury sphygmomanometers (Merc) in subjects atrial fibrillation.We recruited 51 hemodynamically stable fibrillation. Fifty four normal sinus rhythm served as controls. Supine each arm were recorded simultaneously using one monitor Merc. The second then replaced the first repeated. Merc was switched to opposite arm, both monitors...

Coronary artery fistula is an uncommon cardiac anomaly. One-hundred and seventy-two cases without either aortic or pulmonary valve atresia have been documented in the literature by 1969. In this paper, four further as seen Singapore are described. The anterior descending branch of left coronary was involved two cases, circumflex right one case each. atrium ventricle recipient chamber One patients, 11 -year-old Indian boy who presented with ischae-mic pain, operated improved remarkably after...

This present investigation aimed at characterizing the biochemical potential and kinetic study of protease isolated from kitchen wastewater bacteria, P2S1An. The enzymatic activity was optimum when incubated for 96 h, 30°C pH 9.0. purified (PrA) 10.47-folds that crude (S1). PrA about 35 kDa in molecular weight. broad thermal stability, chelators, surfactants solvent tolerance, favorable thermodynamics suggested potentiality extracted PrA. Thermal stability were enhanced presence 1-mM Ca2+...

Adrenal insufficiency (AI) is an uncommon, life-threatening disorder requiring lifelong treatment with steroid therapy and special attention to prevent adrenal crisis. Little known about the prevalence of AI in Canada or healthcare utilization rates by these patients.We aimed assess burden Alberta, Canada.This study used a population-based, retrospective administrative health data approach identify patients diagnosis over 5-year period evaluated emergency outpatient rates, dispense records,...

Women with polycystic ovary syndrome (PCOS) have increased incidence of atherogenic dyslipidemia and cardiovascular disease (CVD). Interventions targeting to reduce CVD risk are limited in women PCOS.This pilot study was conducted determine the effect 12 weeks high dose fish oil (FO), metformin, FO as an adjunct metformin (FO-metformin) therapy on fasting nonfasting plasma lipids ApoB-remnants young metabolic (MetS) PCOS.In this open-label parallel trial, MetS PCOS (18-30 years age) were...