A5051729132- Fuel Cells and Related Materials
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
Chongqing Medical University
2022-2024
Anhui Medical University
2024
First Affiliated Hospital of Anhui Medical University
2024
Chronic overconsumption of lipids followed by their excessive accumulation in the heart leads to cardiomyopathy. The cause lipid-induced cardiomyopathy involves a pivotal role for proton-pump vacuolar-type H+-ATPase (v-ATPase), which acidifies endosomes, and lipid-transporter CD36, is stored acidified endosomes. During lipid overexposure, an increased influx into cardiomyocytes sensed v-ATPase, then disassembles, causing endosomal de-acidification expulsion CD36 from endosomes toward...
Chemerin, an adipocyte-secreted protein, has been recently suggested to be linked metabolic syndrome and cardiac function in obese diabetes mellitus. This study aimed investigate the potential roles of adipokine chemerin on high fat-induced dysfunction. Chemerin (Rarres2) knockout mice, which were fed with either a normal diet or high-fat for 20 weeks, employed observe whether affected lipid metabolism, inflammation, function. Firstly, we found substrate inflexibility Rarres2−/− mice diet....